BIOF Supply High Quality Pregabalin Powder CAS 148553-50-8 3(S)-(AMINOMETHYL)-5-METHYLHEXANOIC ACID

Short Description:

Pregabalin is a medication that belongs to the class of drugs known as anticonvulsants or antiepileptic drugs. Here is an introduction to it:

Mechanism of Action

• Pregabalin works by binding to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. This binding reduces the release of several neurotransmitters, such as glutamate, norepinephrine, and substance P, which are involved in pain signaling and neuronal excitability.

Indications

• Neuropathic Pain: It is widely used to treat various types of neuropathic pain, including diabetic peripheral neuropathy, postherpetic neuralgia, and spinal cord injury-related pain.

• Epilepsy: Pregabalin is also an effective adjunctive therapy for partial-onset seizures in patients with epilepsy.

• Generalized Anxiety Disorder: In addition to its analgesic and antiepileptic properties, pregabalin has been approved for the treatment of generalized anxiety disorder.

Dosage and Administration

• The dosage of pregabalin varies depending on the indication, patient’s age, and renal function. It is usually taken orally, with or without food, two to three times a day.

• When discontinuing pregabalin, the dose should be tapered gradually over at least 1 week to avoid withdrawal symptoms.

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Product Function

• Calcium Channel Modulation: Pregabalin binds to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. This action inhibits the influx of calcium ions into nerve terminals, thereby reducing the release of neurotransmitters like glutamate, norepinephrine, and substance P. By modulating neurotransmitter release, it helps to regulate neuronal excitability and pain signaling.

• Analgesic Effect: Through its action on calcium channels and neurotransmitter regulation, pregabalin effectively blocks pain signals, especially in neuropathic pain conditions. It alters the way the nervous system processes and transmits pain, providing relief to patients.

• Anxiolytic Action: In the brain, pregabalin also has anxiolytic effects by interacting with certain receptors and neural circuits involved in anxiety regulation. It helps to reduce the excessive neuronal activity associated with anxiety, leading to a calming and anti-anxiety effect.

Application

• Neuropathic Pain: Pregabalin is widely used in the treatment of neuropathic pain conditions. For diabetic peripheral neuropathy, it can relieve the burning, tingling, and shooting pain often experienced by patients with diabetes in their extremities. In postherpetic neuralgia, it helps manage the persistent pain that can occur after a shingles infection. It is also beneficial for neuropathic pain associated with spinal cord injury and other nerve damage conditions.

• Epilepsy: As an adjunctive therapy, pregabalin is used in the treatment of partial-onset seizures in patients with epilepsy. It helps to control seizure activity by reducing neuronal excitability in the brain, thereby improving the quality of life for epilepsy patients when used in combination with other antiepileptic drugs.

• Generalized Anxiety Disorder: Pregabalin is approved for the treatment of generalized anxiety disorder. It can reduce the symptoms of excessive worry, restlessness, and tension associated with this disorder, allowing patients to better manage their daily activities and improve their mental well-being.

• Fibromyalgia: In fibromyalgia, a chronic pain disorder characterized by widespread musculoskeletal pain and tenderness, pregabalin can help alleviate pain and improve sleep quality, which is often disrupted in patients with this condition.