Samar da Masana'antu Succinic Acid Amber Acid Cas 110-15-6

Succinic acid dicarboxylic acid ne tare da tsarin sinadarai (CH2)2 (CO2H)2. Sunan ya samo asali ne daga Latin succinum, ma'ana amber. A cikin rayayyun halittu, succinic acid yana ɗaukar nau'i na anion, succinate, wanda yana da ayyuka masu yawa na ilimin halitta azaman matsakaicin matsakaici wanda ake canza shi zuwa fumarate ta hanyar enzyme succinate dehydrogenase a cikin hadaddun 2 na sarkar jigilar lantarki wanda ke da hannu wajen yin ATP, kuma kamar yadda kwayar sigina mai nuna yanayin yanayin rayuwa ta salula. Ana samar da Succinate a cikin mitochondria ta hanyar zagayowar tricarboxylic acid (TCA), tsarin samar da makamashi wanda duk kwayoyin halitta ke rabawa. Succinate na iya fita daga matrix na mitochondrial kuma yana aiki a cikin cytoplasm da kuma sararin samaniya, canza yanayin magana, daidaita yanayin yanayin epigenetic ko nuna siginar hormone. Don haka, succinate yana danganta metabolism na salula, musamman samuwar ATP, zuwa tsarin aikin salula. Dysregulation na succinate kira, sabili da haka ATP kira, faruwa a wasu kwayoyin mitochondrial cututtuka, irin su Leigh ciwo, da kuma Melas ciwo, da kuma lalacewa na iya haifar da pathological yanayi, kamar m canji, kumburi da nama rauni.