Tun daga zuwan samfuran NMN, sun zama sananne da sunan "elixir na rashin mutuwa" da "maganin tsawon rai", kuma kasuwar NMN masu alaƙa sun nemi kasuwa. Li Ka-shing ya dauki NMN na wani dan lokaci, sannan ya kashe dalar Amurka miliyan 200 a Hong Kong wajen raya NMN, kuma kamfanin Warren Buffett ya kuma cimma wani muhimmin hadin gwiwa tare da masana'antun NMN. Shin NMN, wanda manyan attajirai ke so, zai iya yin tasiri na tsawon rai?
NMN shine nicotinamide mononucleotide (Nicotinamide mononucleotide), cikakken suna shine "β-nicotinamide mononucleotide", wanda ke cikin nau'in abubuwan da suka samo asali na bitamin B kuma shine farkon NAD +, wanda za'a iya canzawa zuwa NAD + ta hanyar aiwatar da jerin enzymes. a cikin jiki, don haka ana ɗaukar ƙarin NMN a matsayin hanya mai mahimmanci don inganta matakan NAD +. NAD + shine mabuɗin coenzyme na ciki wanda ke da hannu kai tsaye cikin ɗaruruwan halayen rayuwa, musamman waɗanda ke da alaƙa da samar da kuzari. Yayin da muke tsufa, matakan NAD + a cikin jiki suna raguwa a hankali. Ragewar NAD + zai lalata ikon sel don samar da makamashi, kuma jiki zai fuskanci alamun lalacewa irin su lalacewar tsoka, asarar kwakwalwa, pigmentation, asarar gashi, da dai sauransu, wanda ake kira "tsufa".
Bayan matsakaicin shekaru, matakin NAD + a jikinmu yana raguwa ƙasa da 50% na matakin ƙarami, wanda shine dalilin da ya sa bayan wasu shekaru, yana da wahala a koma yanayin ƙuruciya komai nawa kuka huta. Ƙananan matakan NAD + na iya haifar da cututtuka da yawa da suka shafi tsufa, ciki har da atherosclerosis, arthritis, hawan jini, cututtukan zuciya, raguwar fahimta, cututtukan neurodegenerative, ciwon sukari, da ciwon daji, da sauransu.
A cikin 2020, binciken al'ummar kimiyya kan NMN a zahiri yana cikin ƙuruciya, kuma kusan dukkanin gwaje-gwajen sun dogara ne akan gwaje-gwajen dabbobi da linzamin kwamfuta, kuma gwajin asibiti kawai na ɗan adam a cikin 2020 a wancan lokacin kawai ya tabbatar da "aminci" na abubuwan NMN na baka, kuma bai tabbatar da cewa matakin NAD+ a jikin mutum ya karu ba bayan shan NMN, balle ma yana iya jinkirta tsufa.
Yanzu, bayan shekaru hudu, akwai wasu sabbin ci gaban bincike a NMN.
A cikin gwajin asibiti na kwanaki 60 da aka buga a cikin 2022 akan 80 masu matsakaicin shekaru masu lafiya, abubuwan da ke ɗaukar 600-900mg na NMN kowace rana an tabbatar da su da tasiri wajen haɓaka matakan NAD + a cikin jini, kuma idan aka kwatanta da ƙungiyar placebo, batutuwa waɗanda sun dauki NMN baki da baki suna kara nisan tafiyarsu na mintuna 6, kuma shan NMN na tsawon makonni 12 a jere yana iya inganta ingancin barci, inganta aikin jiki, da inganta karfin jiki, kamar inganta karfin rikewa, inganta saurin tafiya, da sauransu. Yana rage gajiya da bacci, yana karawa. makamashi, da dai sauransu.
Japan ita ce ƙasa ta farko da ta fara gudanar da gwaje-gwajen asibiti na NMN, kuma Makarantar Magunguna ta Jami'ar Keio ta fara gwajin gwaji na asibiti na II a cikin 2017 bayan kammala gwajin asibiti na lokaci na don tabbatar da aminci. An gudanar da binciken gwaji na asibiti ta Shinsei Pharmaceutical, Japan da Makarantar Graduate of Biomedical Sciences and Health, Jami'ar Hiroshima. Binciken, wanda aka fara a cikin 2017 har tsawon shekara guda da rabi, yana da nufin yin nazarin tasirin lafiyar lafiyar amfani da NMN na dogon lokaci.
A karon farko a duniya, an tabbatar da asibiti cewa bayyanar da furotin na tsawon rai yana karuwa bayan gudanar da maganin NMN a cikin mutane, kuma bayyanar da nau'in hormones iri-iri ma yana karuwa.
Alal misali, ana iya bi da shi don inganta tsarin tafiyar da jijiyoyi (neuralgia, da dai sauransu), inganta rigakafi, inganta rashin haihuwa a cikin maza da mata, ƙarfafa tsokoki da kasusuwa, haɓakar ma'aunin hormonal (ingantaccen haɓakawa. fata), karuwar melatonin (inganta barci), da kuma tsufa na kwakwalwa wanda Alzheimer's, Parkinson's disease, ischemic encephalopathy da sauran cututtuka suka haifar.
A halin yanzu akwai bincike da yawa don gano tasirin rigakafin tsufa na NMN a cikin sel daban-daban da kyallen takarda. Amma yawancin aikin ana yin su a cikin vitro ko a cikin dabbobi. Duk da haka, akwai 'yan rahotannin jama'a game da lafiyar dogon lokaci da ingancin aikin asibiti na NMN a cikin mutane. Kamar yadda za a iya gani daga bita a sama, ƙananan ƙananan ƙididdiga na ƙididdiga da bincike na asibiti sun bincika lafiyar lafiyar NMN na dogon lokaci.
Duk da haka, akwai riga da yawa NMN anti-tsufa kari a kasuwa, kuma masana'antun suna rayayye tallan wadannan kayayyakin ta yin amfani da in vitro da in vivo sakamakon a cikin wallafe-wallafe. Sabili da haka, aikin farko ya kamata ya kasance don kafa toxicology, pharmacology, da bayanin lafiyar NMN a cikin mutane, ciki har da masu lafiya da marasa lafiya.
Gabaɗaya, yawancin alamun bayyanar cututtuka da cututtuka na raguwar aikin da aka haifar da "tsufa" suna da sakamako mai ban sha'awa.
Lokacin aikawa: Mayu-21-2024
