Tarihin bitamin B1
Vitamin B1 tsohon magani ne, bitamin B na farko da aka gano.
A cikin 1630, masanin kimiyyar lissafi na Netherlands Jacobs · Bonites ya fara bayyana beriberi a Java (bayanin kula: ba beriberi ba).
A cikin 80s na karni na 19, sojojin ruwa na Japan sun fara gano ainihin dalilin beriberi.
A shekara ta 1886, Dokta Christian · Ekmann, wani jami’in kula da lafiya na Netherlands, ya gudanar da bincike a kan alaƙar guba ko microbial na beriberi kuma ya gano cewa kajin da ke cinye shinkafa mai goge ko farar shinkafa na iya haifar da ciwon neuritis, kuma cin jajayen shinkafa ko fatun shinkafa na iya hana ko ma. warkar da cutar.
A cikin 1911, Dr. Casimir Funk, masani a fannin sinadarai a Landan, ya yi crystallized thiamine daga bran shinkafa kuma ya sa masa suna “bitamin B1”.
A cikin 1936, Williams da Cline11 sun buga daidaitaccen tsari na farko da haɗin bitamin B1.
Ayyukan biochemical na bitamin B1
Vitamin B1 bitamin ne mai narkewa wanda jiki ba zai iya hada shi ba kuma yana buƙatar sha ta hanyar abinci ko kari.
Akwai nau'o'i uku na bitamin B1 a cikin jikin mutum, wato thiamine monophosphate, thiamine pyrophosphate (TPP) da thiamine triphosphate, wanda TPP shine babban nau'i na jiki.
TPP wani cofactor ne ga yawancin enzymes da ke cikin makamashi na makamashi, ciki har da mitochondrial pyruvate dehydrogenase, α-ketoglutarate dehydrogenase hadaddun, da cytosolic transketolase, dukansu suna da hannu a cikin catabolism carbohydrate, kuma duk abin da ke nuna rage yawan aiki a lokacin rashi thiamine.
Thiamine yana taka muhimmiyar rawa a cikin metabolism na jiki, kuma ƙarancin thiamine zai haifar da raguwar samar da adenosine triphosphate (ATP), wanda zai haifar da ƙarancin makamashi na salula; Hakanan zai iya haifar da tarin lactate, samar da radicals kyauta, neuroexcitotoxicity, hanawa na ƙwayar glucose na myelin da samar da amino acid mai sarƙaƙƙiya, kuma a ƙarshe yana haifar da apoptosis.
Alamun farko na rashin bitamin B1
Rashin Thiamine saboda rashin cin abinci mara kyau, malabsorption, ko rashin daidaituwa na metabolism a matakin farko ko na farko.
A mataki na biyu, matakin biochemical, aikin transketolases yana raguwa sosai.
Mataki na uku, matakin ilimin lissafin jiki, yana gabatar da alamomin gabaɗaya kamar raguwar ci, rashin barci, fushi, da rashin lafiya.
A mataki na hudu, ko na asibiti, nau'in alamun bayyanar cututtuka na rashi na thiamine (beriberi) sun bayyana, ciki har da claudication na lokaci-lokaci, polyneuritis, bradycardia, edema na gefe, haɓakar zuciya, da ophthalmoplegia.
Mataki na biyar, matakin anatomical, na iya ganin canje-canjen histopathological saboda lalacewa ga tsarin salula, irin su hypertrophy na zuciya, raguwar granule na cerebellar, da kumburin microglial na cerebral.
Mutanen da ke buƙatar ƙarin bitamin B1
Masu aikin motsa jiki na dogon lokaci suna buƙatar bitamin B1 don shiga cikin kashe kuzari, kuma ana amfani da bitamin B1 yayin motsa jiki.
Mutanen da suke shan taba, sha, da kuma tsayawa a makara na dogon lokaci.
Marasa lafiya masu fama da cututtuka na yau da kullun, musamman ma masu fama da cututtukan zuciya, ciwon sukari, cututtukan koda, cututtukan huhu na huhu, da cututtukan da ke faruwa na numfashi.
A cikin masu fama da cutar hawan jini, yawan adadin bitamin B1 yana ɓacewa a cikin fitsari saboda ana amfani da magungunan diuretic a cikin marasa lafiya da hawan jini. Bugu da ƙari, digoxin na iya rage ikon ƙwayoyin tsoka na zuciya don sha da amfani da bitamin B1.
Kariya don amfani da bitamin B1
1. A lokacin da aka yi amfani da shi a cikin manyan allurai, tabbatar da ingantaccen maida hankali na iya zama da damuwa, kuma obbilogogen na iya zama tabbatacce mai gaskiya.
2. Yakamata a yi amfani da Vitamin B1 kafin allurar glucose don maganin ciwon daji na Wernicke.
3. Ana iya samun bitamin B1 gabaɗaya daga abinci na yau da kullun, kuma ƙarancin monovitamin B1 ba kasafai bane. Idan bayyanar cututtuka sun yi karanci, an fi son bitamin B-complex.
4. Dole ne a sha bisa ga shawarar da aka ba da shawarar, kada ku wuce kima.
5. Tuntuɓi likita ko likitan magunguna don yara.
6 . Mata masu ciki da masu shayarwa yakamata suyi amfani da su a karkashin jagorancin likita.
7. Idan aka yi amfani da fiye da kima ko mummunan halayen, nemi kulawar likita nan da nan.
8. Wadanda ke da rashin lafiyar wannan samfurin an haramta su, kuma waɗanda ke da allergies ya kamata su yi amfani da hankali.
9. An haramta amfani da wannan samfurin lokacin da kaddarorinsa suka canza.
10. Ka kiyaye nesa da yara.
11. Dole ne babba ya kula da yara.
12. Idan kana amfani da wasu magunguna, da fatan za a tuntuɓi likitan ku ko likitan magunguna kafin amfani da wannan samfurin.
Lokacin aikawa: Agusta-09-2024
