Mai ka hiki ʻana mai o nā huahana NMN, ua lilo lākou i mea kaulana i ka inoa o "elixir of immortality" a me "longevity medicine", a ua ʻimi pū ʻia nā waihona manaʻo NMN pili e ka mākeke. Ua lawe ʻo Li Ka-shing i ka NMN no kekahi manawa, a laila ua hoʻolilo ʻo ia i 200 miliona mau kālā Hong Kong ma ka hoʻomohala ʻana i ka NMN, a ua loaʻa pū ka hui ʻo Warren Buffett i kahi hui hoʻolālā me nā mea hana NMN. Hiki i ka NMN, ka mea i makemake ʻia e ka poʻe waiwai kiʻekiʻe, he hopena lōʻihi?
ʻO NMN ka nicotinamide mononucleotide (Nicotinamide mononucleotide), ʻo ka inoa piha ʻo "β-nicotinamide mononucleotide", nona ka māhele o nā huaʻai B derivatives a ʻo ia ka precursor o NAD +, hiki ke hoʻololi ʻia i NAD + ma o ka hana o kahi ʻano enzymes. i loko o ke kino, no laila ua manaʻo ʻia ʻo NMN supplementation he ala kūpono e hoʻomaikaʻi ai i nā pae NAD +. ʻO NAD + kahi coenzyme intracellular koʻikoʻi e pili pono ana i nā haneli o nā hopena metabolic, ʻoi aku ka pili i ka hana ikehu. I ko mākou mau makahiki, e emi mālie nā pae NAD + i ke kino. ʻO ka emi ʻana o ka NAD + e hōʻino i ka hiki o nā cell e hana i ka ikehu, a e ʻike ke kino i nā hōʻailona degenerative e like me ka degeneration muscle, lolo lolo, pigmentation, lauoho lauoho, a me nā mea i kapa ʻia ʻo "ʻelemakule".
Ma hope o ka makahiki waena, hāʻule ka pae NAD + i loko o ko mākou kino ma lalo o 50% o ka pae ʻōpio, ʻo ia ke kumu ma hope o kekahi mau makahiki, he paʻakikī ke hoʻi i ka mokuʻāina o ka ʻōpio me ka nui o kou hoʻomaha. Hiki i nā haʻahaʻa NAD + haʻahaʻa ke alakaʻi i nā maʻi e pili ana i ka ʻelemakule, me ka atherosclerosis, arthritis, high blood pressure, cardiovascular disease, cognitive decline, neurodegenerative maʻi, diabetes, a me ke kanesa, a me nā mea ʻē aʻe.
I ka makahiki 2020, ʻo ka noiʻi ʻana o ke kaiāulu ʻepekema ma NMN i ka wā kamaliʻi, a kokoke i nā hoʻokolohua āpau i hoʻokumu ʻia ma nā hoʻokolohua holoholona a me nā ʻiole, a ʻo ka hoʻokolohua lapaʻau kanaka wale nō ma 2020 i kēlā manawa i hōʻoia i ka "palekana" o nā mea hoʻohui NMN waha. a ʻaʻole i hōʻoia i ka piʻi ʻana o ka pae NAD + i loko o ke kino o ke kanaka ma hope o ka lawe ʻana i ka NMN, ʻaʻole hiki ke hoʻopaneʻe i ka ʻelemakule.
I kēia manawa, ʻehā makahiki ma hope, aia kekahi mau holomua noiʻi hou ma NMN.
I loko o kahi hoʻokolohua lapaʻau 60-lā i paʻi ʻia ma 2022 ma 80 mau kāne olakino waena, ua hoʻopaʻa ʻia nā kumuhana e lawe ana i ka 600-900mg o NMN i kēlā me kēia lā i ka hoʻonui ʻana i nā pae NAD + i loko o ke koko, a hoʻohālikelike ʻia me ka hui placebo, nā kumuhana Ua hoʻonui waha ʻia ʻo NMN i ko lākou 6 mau minuke hele wāwae, a ʻo ka lawe ʻana i ka NMN no 12 mau pule he hiki ke hoʻomaikaʻi i ka maikaʻi o ka hiamoe, hoʻomaikaʻi i ka hana kino, a hoʻomaikaʻi i ka ikaika kino, e like me ka hoʻonui ʻana. ʻO ka ikaika paʻa, hoʻomaikaʻi i ka wikiwiki o ka hele ʻana, etc. Hoʻemi i ka luhi a me ka hiamoe, hoʻonui i ka ikehu, etc.
ʻO Iapana ka ʻāina mua i alakaʻi i nā hoʻokolohua lapaʻau NMN, a ua hoʻomaka ʻo Keio University School of Medicine i kahi hoʻokolohua lapaʻau phase II ma 2017 ma hope o ka hoʻopau ʻana i ka hoʻokolohua lapaʻau o ka pae I e hōʻoia i ka palekana. Ua alakaʻi ʻia ka noiʻi hoʻokolohua lapaʻau e Shinsei Pharmaceutical, Iapana a me ke kula puka kula ʻo Biomedical Science and Health, Ke Kulanui ʻo Hiroshima. ʻO ka haʻawina, i hoʻomaka i ka 2017 no hoʻokahi makahiki a me ka hapa, ke manaʻo nei e aʻo i nā hopena olakino o ka hoʻohana ʻana i ka NMN lōʻihi.
No ka manawa mua ma ka honua, ua hōʻoia ʻia i ka maʻi maʻi e piʻi aʻe ka hōʻike o ka protein longevity ma hope o ka lawelawe waha o NMN i nā kānaka, a piʻi pū ka hōʻike ʻana o nā ʻano hormones.
No ka laʻana, hiki ke mālama ʻia no ka hoʻomaikaʻi ʻana i nā kaʻa hoʻokele nerve (neuralgia, etc.), ka hoʻomaikaʻi ʻana i ka pale ʻana, ka hoʻomaikaʻi ʻana i ka infertility i nā kāne a me nā wahine, ka hoʻoikaika ʻana i nā ʻiʻo a me nā iwi, ka hoʻomaikaʻi ʻana i ka pale hormonal (hoʻomaikaʻi ka ʻili), ka piʻi ʻana o ka melatonin (hoʻomaikaʻi i ka hiamoe), a me ka ʻelemakule o ka lolo i hoʻokumu ʻia e ka maʻi Alzheimer, ka maʻi Parkinson, ischemic encephalopathy a me nā maʻi ʻē aʻe.
I kēia manawa he nui ka noiʻi e ʻimi i nā hopena anti-kahiko o NMN i nā ʻāpana like ʻole a me nā kiko. Akā ʻo ka hapa nui o ka hana i hana ʻia i loko o ka vitro a i ʻole i nā hiʻohiʻona holoholona. Eia nō naʻe, liʻiliʻi nā hōʻike lehulehu e pili ana i ka palekana lōʻihi a me ka anti-aging clinical efficacy o NMN i nā kānaka. E like me ka mea i ʻike ʻia mai ka loiloi ma luna, he helu liʻiliʻi wale nō o nā preclinical a me nā noiʻi lapaʻau i noiʻi i ka palekana o ka hoʻokele lōʻihi o NMN.
Eia nō naʻe, ua nui nā mea hoʻopihapiha anti-aging NMN ma ka mākeke, a ke kūʻai ikaika nei nā mea hana i kēia mau huahana me ka hoʻohana ʻana i nā hopena in vitro a in vivo i ka palapala. No laila, ʻo ka hana mua e hoʻokumu i ka toxicology, pharmacology, a me ka ʻōlelo palekana o NMN i loko o nā kānaka, me nā maʻi olakino a me nā maʻi maʻi.
ʻO nā mea āpau, ʻo ka hapa nui o nā hōʻailona a me nā maʻi o ka emi ʻana o ka hana ma muli o ka "ʻelemakule" he hopena maikaʻi.
Ka manawa hoʻouna: Mei-21-2024
