N-Acetyl Carnosine: He Antioxidant ikaika e hoʻolalelale i ke olakino maka

ʻO N-Acetyl Carnosine (NAC) kahi hui kūlohelohe e pili ana i ka dipeptide carnosine. Ua like ka NAC molecular structure me ka carnosine me ka ʻokoʻa ka lawe ʻana i kahi hui acetyl hou. Hoʻonui ka acetylation i ka NAC i ka hoʻohaʻahaʻa ʻia e ka carnosinase, kahi enzyme e wāwahi i ka carnosine i kāna mau amino acids, beta-alanine a me histidine.
Loaʻa ka Carnosine a me nā derivatives metabolic o carnosine, me ka NAC, i loko o nā ʻiʻo like ʻole akā ʻoi aku ka ʻiʻo ʻiʻo. Loaʻa i kēia mau pūhui nā ʻano hana like ʻole e like me ka free radical scavenger. He mea ia i loko o nā kulu maka i kūʻai ʻia ma ke ʻano he meaʻai meaʻai (ʻaʻole he lāʻau lapaʻau) a ua hāpai ʻia no ka pale ʻana a me ka mālama ʻana i nā maʻi cataracts. He liʻiliʻi nā hōʻike e pili ana i kona palekana, a ʻaʻohe hōʻike hōʻoiaʻiʻo e pili ana ka hui i ke olakino ocular.
ʻO ka hapa nui o ka noiʻi lapaʻau ma NAC i alakaʻi ʻia e Mark Babizhayev o ka hui US-based Innovative Vision Products (IVP), kahi e kūʻai aku ai i nā mālama NAC.
I ka wā o nā hoʻokolohua mua i hana ʻia ma Moscow Helmholtz Research Institute for Eye Diseases, ua hōʻike ʻia ʻo NAC (1% concentration), hiki ke hele mai ka cornea i ka wai hoʻohenehene ma hope o 15 a 30 mau minuke. I ka makahiki 2004, ua hōʻike ʻia ua ʻoi aku ka maikaʻi o ka NAC ma mua o ka placebo i ka hoʻopili maikaʻi ʻana i ka mālamalama o ka lens. Ua hōʻike ʻia kahi noiʻi kanaka mua ʻo NAC i ka maikaʻi o ka NAC i ka hoʻomaikaʻi ʻana i ka ʻike i nā maʻi cataract a hōʻemi i ke ʻano o ka cataract.
Ua hoʻopuka ka hui ʻo Babizhayev i kahi hoʻokolohua lapaʻau i hoʻopaʻa ʻia i kahi placebo o NAC ma 76 mau maka kanaka me nā maʻi maʻi a hiki i ka holomua a hōʻike i nā hopena maikaʻi like no NAC. Eia nō naʻe, ua kūkākūkā ka loiloi ʻepekema 2007 o nā puke o kēia manawa i nā palena o ka hoʻokolohua lapaʻau, me ka ʻike ʻana he haʻahaʻa ka mana helu helu haʻahaʻa o ke aʻo ʻana, kahi helu haʻahaʻa kiʻekiʻe a "ʻaʻole lawa ke ana kumu e hoʻohālikelike ai i ka hopena o NAC", me ka hoʻoholo ʻana "he ʻokoʻa ka nui. Pono ka hoʻokolokolo e hōʻoia i ka pono o ka lāʻau NAC lōʻihi.
Ua paʻi ʻo Babizhayev a me nā hoa hana i kahi hoʻokolohua lapaʻau kanaka hou ma 2009. Ua hōʻike lākou i nā hopena maikaʻi no NAC a me ka hoʻopaʻapaʻa ʻana "ʻo kekahi mau ʻano hoʻolālā wale nō i hoʻolālā ʻia e IVP ... he kūpono i ka pale ʻana a me ka mālama ʻana i ka senile cataract no ka hoʻohana lōʻihi."
Ua aʻo ʻia ʻo N-acetyl carnosine no kona hiki ke kākoʻo i ke olakino a me ke olakino retinal. Hōʻike ka noiʻi hiki i ka N-acetyl carnosine ke kōkua i ka mālama ʻana i ka moʻokalaleo o ka lens (pono no ka ʻike maka) a me ka pale ʻana i nā cell retinal palupalu mai ka pōʻino. Hana kēia mau hopena i ka N-acetyl carnosine i mea waiwai nui no ka hoʻolaha ʻana i ke olakino maka holoʻokoʻa a me ka pale ʻana i ka hana ʻike.
ʻOiai ʻo N-acetyl carnosine e hōʻike ana i ka ʻōlelo hoʻohiki i ke kākoʻo ʻana i ke olakino o ka maka, he mea nui e hoʻomaopopo he pono ka noiʻi hou ʻana e hoʻomaopopo piha i kona hopena lōʻihi a me nā pilina pili me nā lāʻau lapaʻau ʻē aʻe. E like me kekahi mea hoʻonui a lapaʻau paha, pono ʻoe e nīnau i kahi loea mālama ola ma mua o ka hoʻohana ʻana i ka N-acetyl carnosine, ʻoi aku ka nui inā loaʻa iā ʻoe nā maʻi maka a i ʻole e lawe ana i nā lāʻau lapaʻau ʻē aʻe.
Eia kekahi, i ka wā e noʻonoʻo ai i ka hoʻohui ʻana me N-acetyl carnosine, he mea nui ia e koho i kahi huahana kaulana a kiʻekiʻe e hōʻoia i ka maʻemaʻe a me ka pono. Aia nā kulu maka ma ka mākeke i loaʻa i ka N-acetyl carnosine, a no nā hopena maikaʻi loa he mea nui ia e hahai i ke ʻano i ʻōlelo ʻia a me nā kuhikuhi no ka hoʻohana.
I ka hopena, ʻo ka N-acetyl carnosine he hui hoʻohiki me ka mana nui i ke kākoʻo ʻana i ke olakino o ka maka, ʻoi aku hoʻi i ka pale ʻana a me ka mālama ʻana i nā maʻi maka pili makahiki. ʻO kāna mau waiwai antioxidant a me ka hiki ke pale aku i nā maka mai ke koʻikoʻi oxidative e lilo ia i mea waiwai nui no ka pale ʻana i ka hana ʻike a mālama i ke olakino maka holoʻokoʻa. Ke hoʻomau nei ka noiʻi ʻana ma kēia wahi, hiki i ka N-acetyl carnosine ke lilo i kumu nui i ka hāpai ʻana i ka ʻelemakule olakino a me ka mālama ʻana i ka ʻike maka.