He moʻolelo o ka huaora B1
He lāʻau lapaʻau kahiko ka Vitamin B1, ʻo ia ka huaʻa B mua i ʻike ʻia.
I ka makahiki 1630, ua wehewehe mua ka physicist Netherlands ʻo Jacobs · Bonites i ka beriberi ma Java (nota: ʻaʻole beriberi).
I ka makahiki 80 o ke kenekulia 19, ua ʻike mua ʻia ke kumu maoli o ka beriberi e ka Navy Iapana.
I ka makahiki 1886, ua alakaʻi ʻo Kauka Christian Ekmann, he luna lapaʻau ʻo Netherlands, i kahi noiʻi e pili ana i ka ʻona a i ʻole ka microbial correlation o beriberi a ua ʻike ʻo nā moa e ʻai ana i ka laiki polia a keʻokeʻo paha ke kumu o ka neuritis, a ʻo ka ʻai ʻana i ka laiki ʻulaʻula a i ʻole ka ʻōpala raiki hiki ke pale a i ʻole. hoola i ka mai.
I ka makahiki 1911, ʻo Kauka Casimir Funk, he kanaka lapaʻau ma Lākana, ua hoʻokaʻawale i ka thiamine mai loko mai o ka laiki a kapa ʻia ʻo ia ʻo "vitamin B1".
I ka makahiki 1936, ua paʻi ʻo Williams lāua ʻo Cline11 i ka hoʻokumu pololei mua a me ka synthesis o ka huaora B1.
Nā hana biochemical o ka huaora B1
ʻO ka Vitamin B1 he huaʻaola hiki ʻole ke hoʻohui ʻia e ke kino a pono e lawe ʻia ma o ka meaʻai a i ʻole nā mea hoʻohui.
ʻEkolu ʻano o ka huaora B1 i loko o ke kino o ke kanaka, ʻo ia hoʻi ka thiamine monophosphate, thiamine pyrophosphate (TPP) a me ka thiamine triphosphate, ʻo ia ka TPP ke ʻano nui i loaʻa i ke kino.
ʻO ka TPP he cofactor no kekahi mau enzymes i komo i ka ikehu metabolism, me ka mitochondrial pyruvate dehydrogenase, α-ketoglutarate dehydrogenase complex, a me ka cytosolic transketolase, nā mea a pau e pili ana i ka catabolism carbohydrate, a me nā mea a pau e hōʻike ana i ka emi o ka hana i ka wā o ka thiamine deficiency
He kuleana koʻikoʻi ko Thiamine i ka hana ʻana o ke kino, a ʻo ka nele o ka thiamine e hoʻemi i ka hana ʻana o ka adenosine triphosphate (ATP), ka hopena i ka nele o ka ikehu kelepona; Hiki iā ia ke lawe mai i ka lactate accumulation, free radical production, neuroexcitotoxicity, inhibition of myelin glucose metabolism and the production of branched-chain amino acids, and ultimately lead to apoptosis.
ʻO nā hōʻailona mua o ka nele o ka huaora B1
ʻO ka hemahema o Thiamine ma muli o ka ʻai maikaʻi ʻole, malabsorption, a i ʻole ka metabolism maʻamau i ka pae mua a i ʻole ka pae mua.
I ka papa ʻelua, ʻo ka pae biochemical, hoʻemi nui ʻia ka hana o nā transketolases.
ʻO ke kolu o ka pae, ka pae physiological, e hōʻike ana i nā hōʻailona maʻamau e like me ka emi ʻana o ka makemake, insomnia, irritability, a me ka malaise.
I ka hā o ka pae, a i ʻole ka pae lapaʻau, ʻike ʻia kahi ʻano o nā hōʻailona maʻamau o ka thiamine deficiency (beriberi), me ka intermittent claudication, polyneuritis, bradycardia, peripheral edema, cardiac enlargement, a me ophthalmoplegia.
ʻO ka pae ʻelima, ka pae anatomical, hiki ke ʻike i nā loli histopathological ma muli o ka hōʻino ʻana i nā hale kelepona, e like me ka hypertrophy cardiac, ka degeneration layer granule cerebellar, a me ka pehu cerebral microglial.
ʻO ka poʻe e pono ai ka hoʻohui ʻana i ka vitamina B1
Pono nā mea hoʻoikaika kino lōʻihi i ka huaora B1 e komo i ka hoʻolilo ikehu, a hoʻohana ʻia ka huaora B1 i ka wā hoʻoikaika kino.
ʻO ka poʻe puhi, inu, a moe pō no ka manawa lōʻihi.
ʻO nā maʻi me nā maʻi maʻi mau, ʻoi aku ka nui o nā maʻi me ka maʻi maʻi cardiovascular, diabetes, maʻi kīkī, maʻi pulmonary obstructive mau, a me nā maʻi maʻi hanu mau.
I nā poʻe maʻi me ke koko kiʻekiʻe, ua nalowale ka nui o ka huaora B1 i ka mimi no ka mea hoʻohana mau ʻia nā diuretics i nā maʻi me ke koko kiʻekiʻe. Eia kekahi, hiki i ka digoxin ke hoʻemi i ka hiki o nā ʻiʻo ʻiʻo o ka puʻuwai e komo a hoʻohana i ka huaora B1.
ʻO ka mālama ʻana no ka hoʻohana ʻana i ka huaora B1
1. Ke hoʻohana ʻia i nā ʻano nui, hiki ke hoʻopilikia ʻia ka hoʻoholo ʻana o ka serum theophylline concentration, hiki ke hoʻonui wahaheʻe i ka hoʻoholo ʻana o ka waika uric, a hiki i ka urobilinogen ke hoʻopunipuni.
2. Pono e hoʻohana ʻia ka Vitamin B1 ma mua o ka hoʻokō ʻana i ka glucose no ka mālama ʻana i ka encephalopathy o Wernicke.
3. Hiki ke ʻai ʻia ka Vitamin B1 mai ka meaʻai maʻamau, a he kakaikahi ka hemahema o ka monovitamin B1. Inā hemahema nā hōʻailona, ʻoi aku ka maikaʻi o ka vitamina B-complex.
4. Pono e lawe ʻia e like me ka mea i ʻōlelo ʻia, mai hoʻonui.
5. E nīnau i ke kauka a i ʻole ka lāʻau lapaʻau no nā keiki.
6 . Pono nā wahine hāpai a me ka lactating e hoʻohana ma lalo o ke alakaʻi a ke kauka.
7. I ka hihia o ka overdose a i ʻole nā hopena koʻikoʻi, e ʻimi koke i ka lāʻau lapaʻau.
8. ʻAʻole pāpā ʻia ka poʻe maʻi maʻi i kēia huahana, a ʻo ka poʻe me ka allergies e hoʻohana me ka akahele.
9. ʻAʻole ʻae ʻia ka hoʻohana ʻana i kēia huahana ke hoʻololi kona mau waiwai.
10. E mālama i kahi e hiki ai i nā keiki.
11. Pono e mālama ʻia nā keiki e ke kanaka makua.
12. Inā hoʻohana ʻoe i nā lāʻau lapaʻau ʻē aʻe, e ʻoluʻolu e nīnau i kāu kauka a lāʻau lapaʻau paha ma mua o ka hoʻohana ʻana i kēia huahana.
Ka manawa hoʻouna: ʻAukake-09-2024
