Keeb kwm ntawm vitamin B1
Vitamin B1 yog ib qho tshuaj thaum ub, thawj cov vitamin B nrhiav pom.
Xyoo 1630, Netherlands physicist Jacobs · Bonites thawj zaug piav txog beriberi hauv Java (ceeb toom: tsis yog beriberi).
Nyob rau hauv lub 80s ntawm lub xyoo pua 19th, qhov tseeb ua rau beriberi yog thawj zaug pom los ntawm Nyiv Navy.
Xyoo 1886, Dr. Christian · Ekmann, ib tug kws kho mob hauv Netherlands, tau tshawb fawb txog cov tshuaj toxicity los yog microbial correlation ntawm beriberi thiab pom tias qaib uas noj polished los yog mov dawb tuaj yeem ua rau mob neuritis, thiab noj mov liab lossis mov husks tuaj yeem tiv thaiv lossis txawm tias. kho tus kab mob.
Xyoo 1911, Dr. Casimir Funk, kws kho mob hauv London, tau ua cov thiamine crystallized los ntawm cov nplej nplej thiab hu ua "vitamin B1".
Xyoo 1936, Williams thiab Cline11 tau luam tawm thawj cov qauv tsim nyog thiab kev sib txuas ntawm vitamin B1.
Kev ua haujlwm biochemical ntawm vitamin B1
Vitamin B1 yog ib qho dej-soluble vitamin uas tsis tuaj yeem tsim los ntawm lub cev thiab yuav tsum tau noj los ntawm kev noj zaub mov lossis ntxiv.
Muaj peb hom vitamin B1 nyob rau hauv tib neeg lub cev, uas yog thiamine monophosphate, thiamine pyrophosphate (TPP) thiab thiamine triphosphate, uas TPP yog lub ntsiab daim ntawv muaj nyob rau hauv lub cev.
TPP yog cov cofactor rau ntau cov enzymes koom nrog hauv lub zog metabolism, suav nrog mitochondrial pyruvate dehydrogenase, α-ketoglutarate dehydrogenase complex, thiab cytosolic transketolase, tag nrho cov koom nrog hauv carbohydrate catabolism, thiab tag nrho cov uas ua rau txo qis kev ua si thaum lub sij hawm thiamine deficiency.
Thiamine ua lub luag haujlwm tseem ceeb hauv lub cev metabolism, thiab thiamine deficiency yuav ua rau txo qis hauv kev tsim cov adenosine triphosphate (ATP), uas ua rau lub zog ntawm tes tsis muaj zog; Nws kuj tseem tuaj yeem ua rau muaj lactate tsub zuj zuj, kev tsim tawm dawb radical, neuroexcitotoxicity, inhibition ntawm myelin qabzib metabolism thiab tsim cov ceg-chain amino acids, thiab thaum kawg ua rau apoptosis.
Cov tsos mob ntxov ntawm vitamin B1 tsis txaus
Thiamine deficiency vim kev noj zaub mov tsis zoo, malabsorption, lossis cov metabolism hauv lub cev tsis zoo nyob rau thawj theem lossis thawj theem.
Hauv theem ob, theem biochemical, kev ua haujlwm ntawm transketolases tau txo qis.
Qhov thib peb theem, theem physiological, nthuav tawm cov tsos mob xws li tsis qab los noj mov, insomnia, chim siab, thiab malaise.
Hauv theem plaub, lossis theem kho mob, ntau cov tsos mob tshwm sim ntawm thiamine deficiency (beriberi) tshwm sim, suav nrog kev sib cuam tshuam claudication, polyneuritis, bradycardia, peripheral edema, plawv o, thiab ophthalmoplegia.
Qhov thib tsib, theem anatomical, tuaj yeem pom cov kev hloov pauv ntawm cov kab mob hauv lub cev vim kev puas tsuaj rau cov qauv ntawm tes, xws li mob plawv hypertrophy, cerebellar granule txheej degeneration, thiab cerebral microglial o.
Cov neeg uas xav tau cov vitamin B1 ntxiv
Cov neeg ua haujlwm siab siv sijhawm ntev xav tau cov vitamin B1 los koom rau hauv kev siv hluav taws xob, thiab vitamin B1 yog siv thaum lub sijhawm ua haujlwm.
Cov neeg haus luam yeeb, haus dej haus, thiab nyob twj ywm ntev ntev.
Cov neeg mob uas muaj kab mob ntev, tshwj xeeb tshaj yog cov neeg mob uas muaj kab mob plawv, ntshav qab zib mellitus, kab mob raum, kab mob obstructive pulmonary, thiab cov kab mob ua pa rov tshwm sim.
Hauv cov neeg mob ntshav siab, ntau cov vitamin B1 poob rau hauv cov zis vim tias cov tshuaj diuretics feem ntau siv rau cov neeg mob ntshav siab. Tsis tas li ntawd, digoxin kuj tseem tuaj yeem txo lub peev xwm ntawm cov leeg hlwb kom nqus tau thiab siv cov vitamin B1.
Kev ceev faj rau kev siv cov vitamin B1
1. Thaum siv cov koob tshuaj loj, kev txiav txim siab ntawm cov ntshav theophylline concentration tuaj yeem cuam tshuam, kev txiav txim siab ntawm uric acid concentration tuaj yeem ua rau muaj kev dag ntxias, thiab urobilinogen tuaj yeem ua rau tsis zoo.
2. Vitamin B1 yuav tsum tau siv ua ntej txhaj tshuaj rau kev kho mob ntawm Wernicke's encephalopathy.
3. Vitamin B1 feem ntau tuaj yeem noj tau los ntawm cov zaub mov ib txwm muaj, thiab qhov tsis txaus ntawm monovitamin B1 yog tsawg. Yog tias cov tsos mob tsis txaus, qhov zoo dua ntawm B-complex vitamin.
4. Yuav tsum tau noj raws li kev pom zoo, tsis txhob noj ntau dhau.
5. Nrog ib tus kws kho mob lossis kws muag tshuaj rau menyuam yaus.
6. Cov poj niam cev xeeb tub thiab lactating poj niam yuav tsum siv raws li kev qhia ntawm tus kws kho mob.
7. Nyob rau hauv cov ntaub ntawv ntawm overdose los yog tshwm sim tsis zoo tshwm sim, mus nrhiav kev kho mob tam sim ntawd.
8. Cov neeg uas tsis haum rau cov khoom no yog txwv tsis pub, thiab cov neeg uas muaj kev fab tshuaj yuav tsum tau ceev faj.
9. Nws yog txwv tsis pub siv cov khoom no thaum nws cov khoom hloov pauv.
10. Khaws kom deb ntawm cov menyuam yaus.
11. Cov menyuam yaus yuav tsum tau saib xyuas los ntawm ib tus neeg laus.
12. Yog tias koj siv lwm cov tshuaj, thov nrog koj tus kws kho mob lossis kws muag tshuaj ua ntej siv cov khoom no.
Post lub sij hawm: Aug-09-2024
