Ebe ọ bụ na ọbịbịa nke ngwaahịa NMN, ha aghọwo ndị a ma ama n'aha "elixir nke anwụghị anwụ" na "ọgwụ ogologo ndụ", na ahịa ahịa na-achọkwa ngwaahịa NMN metụtara. Li Ka-shing ewerela NMN ruo oge ụfọdụ, wee mefuo nde dollar 200 Hong Kong na mmepe NMN, ụlọ ọrụ Warren Buffett bịakwara na ndị na-emepụta NMN na-emekọ ihe ọnụ. NMN, nke ndị ọgaranya kacha amasị, nwere ike nwee mmetụta ogologo ndụ n'ezie?
NMN bụ nicotinamide mononucleotide (Nicotinamide mononucleotide), aha zuru oke bụ "β-nicotinamide mononucleotide", nke bụ ụdị nke vitamin B na-emepụta ma bụrụ ihe mmalite nke NAD +, nke nwere ike ịtụgharị na NAD + site n'omume nke usoro enzymes. n'ime ahụ, yabụ a na-ahụta mgbakwunye NMN dị ka ụzọ dị irè iji melite ọkwa NAD +. NAD + bụ isi coenzyme intracellular nke na-etinye aka na narị narị mmeghachi omume metabolic, ọkachasị ndị metụtara mmepụta ume. Ka anyị na-aka nká, ọkwa NAD + n'ime ahụ ji nwayọọ nwayọọ na-agbada. Mbelata nke NAD + ga-emebi ikike nke mkpụrụ ndụ imepụta ume, ahụ ga-enwetakwa mgbaàmà na-emebi emebi dị ka mmebi ahụ ike, ụbụrụ ụbụrụ, agba agba, ntutu isi, wdg, nke a na-akpọkarị "ịka nká".
Mgbe afọ iri gasịrị, ọkwa NAD + dị n'ahụ anyị na-agbada n'okpuru 50% nke ọkwa nke obere, nke mere na mgbe afọ ole na ole gasịrị, ọ na-esiri ike ịlaghachi na ọnọdụ ntorobịa n'agbanyeghị ole ị zuru ike. Ọkwa NAD + dị ala nwekwara ike ibute ọtụtụ ọrịa ndị metụtara ịka nká, gụnyere atherosclerosis, ogbu na nkwonkwo, ọbara mgbali elu, ọrịa obi, mbelata ọgụgụ isi, ọrịa neurodegenerative, ọrịa shuga, na kansa, n'etiti ndị ọzọ.
Na 2020, nyocha nke ndị sayensị na NMN bụ n'ezie nwata, na ihe fọrọ nke nta ka ọ bụrụ nnwale niile dabere na nnwale anụmanụ na òké, na naanị nnwale ụlọ ọgwụ mmadụ na 2020 n'oge ahụ gosipụtara “nchekwa” nke mgbakwunye NMN ọnụ. ma kwenyeghị na ọkwa NAD + dị na ahụ mmadụ mụbara mgbe ọ nwụsịrị NMN, ma ya fọdụkwa na ọ nwere ike igbu oge ịka nká.
Ugbu a, afọ anọ ka e mesịrị, enwere ọganihu nyocha ọhụrụ na NMN.
N'ime nnwale ụlọ ọgwụ ụbọchị 60 nke ebipụtara na 2022 na ụmụ nwoke 80 dị afọ iri na ụma, ndị mmadụ na-ewere 600-900mg nke NMN kwa ụbọchị ka ọ dị irè n'ịbawanye ọkwa NAD + n'ọbara, ma e jiri ya tụnyere ndị otu placebo. were NMN ọnụ ọnụ na-amụba ogologo ije nke nkeji 6 ha, na iwere NMN maka izu iri na abụọ n'usoro nwere ike ime ka ụra dịkwuo mma, melite ọrụ anụ ahụ, na imeziwanye ike anụ ahụ, dị ka ịkwalite ike njide, ịkwalite ọsọ ije, wdg. Na-ebelata ike ọgwụgwụ na iro ụra, na-abawanye ụba. ike, wdg.
Japan bụ obodo mbụ mere nnwale ụlọ ọgwụ NMN, ụlọ akwụkwọ ọgwụ nke Mahadum Keio malitere usoro nnwale ụlọ ọgwụ nke Abụọ na 2017 mgbe emechara nnwale ụlọ ọgwụ nke mbụ iji hụ na nchekwa. Emere nyocha nyocha ụlọ ọgwụ Shinsei Pharmaceutical, Japan na ụlọ akwụkwọ gụsịrị akwụkwọ nke sayensị biomedical na ahụike, Mahadum Hiroshima. Ọmụmụ ihe ahụ, nke malitere na 2017 maka otu afọ na ọkara, bu n'obi mụọ mmetụta ahụike nke iji NMN ogologo oge.
Na nke mbụ n'ụwa, a kwadoro na nkwupụta nke protein ogologo ndụ na-abawanye mgbe nchịkwa ọnụ nke NMN na ụmụ mmadụ, na nkwupụta nke ụdị hormone dị iche iche na-abawanye.
Dịka ọmụmaatụ, enwere ike ịgwọ ya maka mmelite nke sekit conduction akwara (neuralgia, wdg), mmụba nke mgbochi, mmụba nke infertility na ụmụ nwoke na ụmụ nwanyị, ike nke mọzụlụ na ọkpụkpụ, mmụba nke nguzozi nke hormonal (mmeziwanye nke ahụ). akpụkpọ anụ), mmụba nke melatonin (mmelite nke ụra), na ịka nká nke ụbụrụ nke ọrịa Alzheimer, ọrịa Parkinson kpatara, encephalopathy ischemic na ọrịa ndị ọzọ.
Enwere otutu nyocha ugbu a iji chọpụta mmetụta mgbochi ịka nká nke NMN na sel na anụ ahụ dị iche iche. Mana ọtụtụ n'ime ọrụ a na-arụ na vitro ma ọ bụ ụdị anụmanụ. Otú ọ dị, enwere akụkọ ole na ole ọha na eze banyere nchekwa ogologo oge na mgbochi ịka nká nke NMN n'ime mmadụ. Dị ka a na-ahụ site na nyochaa n'elu, ọ bụ naanị ọnụ ọgụgụ dị nta nke nyocha nyocha na nyocha ahụike enyochala nchekwa nke nlekọta ogologo oge nke NMN.
Otú ọ dị, enweelarị ọtụtụ NMN mgbochi ịka nká n'ahịa, ndị na-emepụta na-erekwa ngwaahịa ndị a nke ọma site na iji in vitro na in vivo na-arụpụta akwụkwọ. Ya mere, ọrụ mbụ kwesịrị ịbụ ịmepụta toxicology, nkà mmụta ọgwụ, na profaịlụ nchekwa nke NMN n'ime mmadụ, gụnyere ahụike na ndị ọrịa.
N'ihe niile, ọtụtụ n'ime ihe mgbaàmà na ọrịa nke nkwụsị ọrụ nke "ịka nká" kpatara nwere nsonaazụ na-ekwe nkwa.
Oge nzipu: Mee-21-2024
