Tartaric acid, nke a makwaara dị ka 'kojic acid' ma ọ bụ 'kojic acid', bụ ngwaahịa fermentation microbial nke a na-achọta na soy sauce, soy bean paste, breeze mmanya, a pụkwara ịhụ ya n'ọtụtụ ngwaahịa fermented nke Aspergillus gbakere.
Ndị ọkà mmụta sayensị mbụ chọpụtara na aka ndị inyom na-arụ ọrụ ebe a na-eme mmanya na-acha ọcha. Mgbe ọmụmụ nke ngwaahịa gbaa ụka, a chọpụtara na ọ bụghị naanị na ọ nwere ezigbo ọrụ na-echekwa ịdị ọhụrụ nke curvilinear acid. Ọ nwekwara mmetụta dị mma na-acha ọcha na-egbuke egbuke. Ọbụna, ụda akpụkpọ abụghị ihe na-echegbu. Ọtụtụ ndị ọkà mmụta ọgwụ na Europe na America na-eji 2 ruo 4% nke kojic acid na-agwọ chlorasma na ndị ọrịa ha nwere mmetụta dị mma.
Kojic acid nwere ike igbochi ọrụ tyrosinase ma kwụsị mmepụta nke melanin. Kojic acid na ntinye nke 20 μg / ml nwere ike igbochi ọrụ nke ọtụtụ enzymes tyrosinase site na 70%-80%. Na ihe ịchọ mma, a na-atụ aro ka ịgbakwunye 0,5% -2% nke tretinoin, nke nwere ike igbochi mmepụta nke melanin ma nweta mmetụta nke ịcha ọcha na ntụpọ ọkụ.
Na mgbakwunye na mmetụta ya na-acha ọcha, kojic acid nwere ihe nchacha nke radical free na ihe antioxidant. Ọ nwere ike inyere akpụkpọ anụ astringent aka, kwalite nchịkọta protein ma mee ka akpụkpọ ahụ sie ike. Ọ bụghị naanị na ọ nwere ụfọdụ ihe na-egbu egbu, kamakwa ọ nwere ikike ime mmiri na ọbụna enwere ike iji ya dị ka ihe nchekwa maka nri na ihe ịchọ mma. Kkojic acid nwere ike igbochi ọrụ hyaluronidase, nke mere na ọ nwekwara ike igbochi allergies.
Kojic acid, nke yiri VC, na-ejikọta ya na ion ọla kọpa ma na-egbochi tyrosinase.
Kojic acid na-egbochikwa mmepụta nke melanin oxidation intermediates. A na-eme ka acid Kojic oxidized site na etiti dopaquinone, si otú a na-ebelata mkpụrụ okwu mmeghachi omume yinye ma gbochie ntụgharị nke melanin etiti site na ụdị dopaquinone na melanin ikpeazụ. Mbelata nke ala na-enwe ike nweta nsonaazụ dị mma maka mmetụta ime ihe ike ya. Ọ bụkwa n'ihi na mmetụta ya siri ike nke nwere ike iduga na-acha ọbara ọbara na kọntaktị dermatitis. N'ihi ya, ọ bụ ya mere ọtụtụ ngwaahịa ndị na-acha ọcha na-enwe obere mgbakwunye.
Uru nke kojic acid bụ nnabata transdermal dị elu, ezigbo mgbochi tyrosinase na enweghị mmetụta cytotoxic. Enwere ike iji ya mee ihe maka ịcha ọcha, iwepụ ntụpọ, imezi ụda akpụkpọ anụ, wdg; na ọ nwekwara ike na-eje ozi iji dowe mmiri ma na-abawanye nhịahụ akpụkpọ ahụ.
Mgbe ị na-eji kojic acid, ọ kacha mma ịṅa ntị na isi ihe ndị a.
Nke mbụ, kojic acid ga-ada na ìhè na-egbuke egbuke ma ọ bụ gburugburu acidic siri ike kama na-abawanye melanin.Ya mere, a na-atụ aro ka a na-eji ngwaahịa kojic acid mee ihe naanị n'abalị.
Nke abụọ, na-ezere iji salicylic acid, mkpụrụ osisi, nnukwu ntinye nke VC na ihe ndị ọzọ. Ọ dị mfe ịmegharị akpụkpọ ahụ ma tụgharịa ma mebie ihe mgbochi ahụ site n'ịkọba ihe ndị dị ike nke na-akpasu iwe. Nke atọ, ọ dị mkpa ka ịme mmiri mmiri siri ike, ṅaa ntị na sunscreen iji gbochie mgbochi nwa.
Ọ bụ ezie na kojic acid bụ ace na oghere na ụwa na-acha ọcha, ọ dị mkpa ka e jiri ya mee ihe nke ọma ma jiri ya mee ihe nke ọma ka o wee nwee ike ịrụ ọrụ dị mkpa.
Oge nzipu: Jun-08-2024
