Akụkọ banyere vitamin B1
Vitamin B1 bụ ọgwụ oge ochie, vitamin B nke mbụ achọpụtara.
Na 1630, onye ọkà mmụta sayensị Netherlands bụ Jacobs · Bonites kọwara beriberi na Java (dee: ọ bụghị beriberi).
Na 80s nke narị afọ nke 19, ndị agha mmiri Japan chọtara ezigbo ihe kpatara beriberi.
Na 1886, Dr. Christian · Ekmann, onye ọrụ ahụike Netherlands, mere nnyocha banyere nsí ma ọ bụ microbial correlation nke beriberi wee chọpụta na ọkụkọ ndị na-eri osikapa a na-egbu maramara ma ọ bụ na-acha ọcha nwere ike ịkpata neuritis, na iri osikapa ma ọ bụ osikapa nwere ike igbochi ma ọ bụ ọbụna gwọọ ọrịa.
Na 1911, Dr. Casimir Funk, onye na-ahụ maka ọgwụ na London, kpụrụ thiamine sitere na bran osikapa wee kpọọ ya “vitamin B1″.
N'afọ 1936, Williams na Cline11 bipụtara nhazi na njikọ nke vitamin B1 ziri ezi nke mbụ.
Biochemical ọrụ nke vitamin B1
Vitamin B1 bụ vitamin na-agbaze mmiri nke ahụ na-enweghị ike ịmepụta ya, ọ dịkwa mkpa ka e were ya site na nri ma ọ bụ mgbakwunye.
Enwere ụdị vitamin B1 atọ n'ime ahụ mmadụ, ya bụ thiamine monophosphate, thiamine pyrophosphate (TPP) na thiamine triphosphate, nke TPP bụ isi ụdị dị na ahụ.
TPP bụ onye na-akwado ọtụtụ enzymes na-etinye aka na metabolism ike, gụnyere mitochondrial pyruvate dehydrogenase, α-ketoglutarate dehydrogenase complex, na cytosolic transketolase, nke niile na-etinye aka na catabolism carbohydrate, na ihe niile na-egosipụta ọrụ mbelata n'oge ụkọ thiamine.
Thiamine na-arụ ọrụ dị oke mkpa na metabolism nke ahụ, na ụkọ thiamine ga-eme ka mbelata mmepụta nke adenosine triphosphate (ATP), na-ebute ụkọ ike cell; Ọ nwekwara ike iweta mkpokọta lactate, mmepụta radical free, neuroexcitotoxicity, mgbochi nke myelin glucose metabolism na mmepụta nke amino acids nwere eriri, na n'ikpeazụ na-eduga na apoptosis.
Mgbaàmà mmalite nke ụkọ vitamin B1
Enweghị thiamine n'ihi nri na-adịghị mma, malabsorption, ma ọ bụ metabolism na-adịghị mma na nke mbụ ma ọ bụ mmalite.
Na ọkwa nke abụọ, usoro biochemical, ọrụ transketolases na-ebelata nke ukwuu.
Nkeji nke atọ, usoro ọmụmụ ahụ, na-egosi ihe mgbaàmà n'ozuzu dịka mbelata agụụ, ehighị ụra nke ọma, mgbakasị ahụ, na ahụ erughị ala.
N'ọkwa nke anọ, ma ọ bụ n'ụlọ ọgwụ, a na-egosi ụdị mgbaàmà dị iche iche nke ụkọ thiamine (beriberi), gụnyere claudication intermittent, polyneuritis, bradycardia, edema peripheral, mmụba obi obi, na ophthalmoplegia.
Nkeji nke ise, ogbo anatomical, nwere ike ịhụ mgbanwe histopathological n'ihi mmebi nke akụkụ cellular, dị ka hypertrophy obi obi, cerebellar granule Layer degeneration, na cerebral microglial ọzịza.
Ndị mmadụ chọrọ vitamin B1 supplementation
Ndị na-eme mgbatị ahụ dị elu ogologo oge chọrọ vitamin B1 iji sonye na mmefu ike, na vitamin B1 na-eji n'oge mgbatị ahụ.
Ndị na-aṅụ sịga, na-aṅụ ihe ọṅụṅụ, na-ehi ụra ruo ogologo oge.
Ndị na-arịa ọrịa na-adịghị ala ala, karịsịa ndị ọrịa na-arịa ọrịa obi, ọrịa shuga, ọrịa akụrụ, ọrịa akpa ume na-adịghị ala ala, na ọrịa akụkụ okuku ume na-emekarị.
N'ime ndị ọrịa nwere ọbara mgbali elu, nnukwu vitamin B1 na-efunahụ na mmamịrị n'ihi na a na-ejikarị diuretics eme ihe na ndị ọrịa nwere ọbara mgbali elu. Na mgbakwunye, digoxin nwekwara ike ibelata ikike mkpụrụ ndụ akwara obi ịnabata na iji vitamin B1.
Akpachara anya maka iji vitamin B1
1. Mgbe etinyere ya na nnukwu doses, mkpebi siri ike nke serum theophylline nwere ike imebi, mkpebi siri ike nke uric acid nwere ike ịbawanye n'ụzọ ụgha, na urobilinogen nwere ike ịbụ ụgha.
2. Ekwesịrị iji vitamin B1 tupu ịgbanye glucose maka ọgwụgwọ nke encephalopathy Wernicke.
3. Enwere ike itinye vitamin B1 n'ozuzu site na nri nkịtị, na ụkọ monovitamin B1 dị ụkọ. Ọ bụrụ na mgbaàmà erughị eru, a na-ahọrọ vitamin B-mgbagwoju anya.
4. A ga-ewere ya dị ka usoro ọgwụgwọ a tụrụ aro ya si dị, emela oke.
5. Kpọtụrụ dọkịta ma ọ bụ onye na-ere ọgwụ maka ụmụaka.
6 . Ndị inyom dị ime na ndị na-enye nwa kwesịrị iji n'okpuru nduzi nke dọkịta.
7. N'ihe banyere ịṅụbiga mmanya ókè ma ọ bụ mmeghachi omume ọjọọ, chọọ nlekọta ahụike ozugbo.
8. A machibidoro ndị nwere ihe nfụkasị ahụ na ngwaahịa a, na ndị nwere allergies kwesịrị iji nlezianya mee ihe.
9. Amachibidoro iji ngwaahịa a mgbe ihe onwunwe ya gbanwere.
10. Debe ebe ụmụaka na-agaghị eru.
11. Okenye ga-elekọta ụmụaka.
12. Ọ bụrụ na ị na-eji ọgwụ ndị ọzọ, biko kpọtụrụ dọkịta gị ma ọ bụ onye na-ere ọgwụ tupu iji ngwaahịa a.
Oge nzipu: Ọgọst-09-2024
