The third Generation of Carnosine Derivatives:N-acetyl carnosine

In the history of China, bird’s nest has been regarded as a tonic, known as “Oriental Caviar”. It is recorded in Materia Medica that bird’s nest is “a tonic and can be cleansed, and is the holy medicine for regulating deficiency and labor”. N-Acetyl Neuraminic Acid is the main ingredient of bird’s nest, so it is also known as bird’s nest acid, and its content is also the indicator of bird’s nest grade.

N-acetyl carnosine (NAC) is a naturally occurring compound chemically related to the dipeptide carnosine.The molecular structure of NAC is identical to that of carnosine except that it carries an additional acetyl group. Acetylation makes NAC more resistant to degradation by myostatin, an enzyme that breaks down myostatin into its constituent amino acids β-alanine and histidine.

O-Acetyl Carnosine is a naturally occurring carnosine derivative that was first identified in rabbit muscle tissue in 1975. In humans, acetyl carnosine is found primarily in skeletal muscle, and muscle tissue releases the component when a person is exercising.

As the third generation of natural carnosine derivatives, acetyl carnosine has stronger overall strength, acetylation modification makes it less likely to be recognized and degraded by carnosine peptidase in the human body, and has higher stability.They have obvious effects in antioxidant, anti-glycation, anti-inflammation, etc.

Acetyl carnosine not only significantly improves the stability, but also inherits the excellent antioxidant and anti-inflammatory effects of carnosine.

Acetyl carnosine has multiple effects, not only can play a firming, soothing, moisturizing and other skin care effects, but also inhibit the generation of reactive oxygen free radicals, inflammatory factors, has been widely used in the treatment of cataract symptoms of eye drops.

Acetyl carnosine is also often used in some cosmetics or care products.For example, skin care products for face, body, neck, hands, and periocular skin; beauty and care products (e.g., lotions, AM/PM creams, serums); antioxidants, skin conditioners, or moisturizers in cosmetics and skincare products; and healing enhancers in ointments.

To summarize, as naturally occurring substances in the human body, myostatin and its derivatives have a very high degree of safety.

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Post time: May-31-2024
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