Kuyambira pomwe zida za NMN zidayamba kutchuka, zakhala zodziwika bwino m'dzina la "elixir of immortal" ndi "mankhwala a moyo wautali", komanso zida zofananira za NMN zakhala zikufunidwanso pamsika. Li Ka-shing adatenga NMN kwa nthawi yayitali, kenako adawononga madola 200 miliyoni a Hong Kong pa chitukuko cha NMN, ndipo kampani ya Warren Buffett idafikiranso mgwirizano wabwino ndi opanga NMN. Kodi NMN, yomwe imakondedwa ndi olemera kwambiri, ikhoza kukhala ndi moyo wautali?
NMN ndi nicotinamide mononucleotide (Nicotinamide mononucleotide), dzina lathunthu ndi "β-nicotinamide mononucleotide", yomwe ili m'gulu la zotumphukira za vitamini B ndipo ndi kalambulabwalo wa NAD +, yomwe imatha kusinthidwa kukhala NAD + kudzera m'magulu angapo a michere. m'thupi, kotero kuwonjezera kwa NMN kumawonedwa ngati njira yabwino yopititsira patsogolo milingo ya NAD +. NAD + ndi gawo lofunikira la intracellular coenzyme lomwe limakhudzidwa mwachindunji ndi mazana a machitidwe a metabolic, makamaka okhudzana ndi kupanga mphamvu. Tikamakalamba, milingo ya NAD + m'thupi imatsika pang'onopang'ono. Kuchepa kwa NAD + kudzasokoneza mphamvu ya ma cell kupanga mphamvu, ndipo thupi lidzakhala ndi zizindikiro zofooka monga kufooka kwa minofu, kutayika kwa ubongo, mtundu wa pigment, tsitsi, ndi zina zotero, zomwe nthawi zambiri zimatchedwa "kukalamba".
Pambuyo pa zaka zapakati, mlingo wa NAD + m'thupi mwathu umatsika pansi pa 50% ya msinkhu waung'ono, chifukwa chake pambuyo pa msinkhu winawake, zimakhala zovuta kubwerera ku chikhalidwe cha unyamata ngakhale mutapuma bwanji. Miyezo yotsika ya NAD + imathanso kuyambitsa matenda ambiri okhudzana ndi ukalamba, kuphatikiza matenda a atherosclerosis, nyamakazi, kuthamanga kwa magazi, matenda amtima, kuchepa kwa chidziwitso, matenda a neurodegenerative, matenda a shuga, ndi khansa, pakati pa ena.
Mu 2020, kafukufuku wa gulu la asayansi pa NMN analidi ali wakhanda, ndipo pafupifupi zoyeserera zonse zidatengera kuyesa kwa nyama ndi mbewa, ndipo mayeso okhawo achipatala a anthu mu 2020 panthawiyo adangotsimikizira "chitetezo" chamankhwala amkamwa a NMN, ndipo sanatsimikizire kuti mulingo wa NAD + m'thupi la munthu unakula atatenga NMN, osasiyapo kuti zitha kuchedwetsa kukalamba.
Tsopano, patatha zaka zinayi, pali kafukufuku watsopano mu NMN.
M'mayesero azachipatala a masiku 60 omwe adasindikizidwa mu 2022 pa amuna 80 athanzi lazaka zapakati, anthu omwe amatenga 600-900mg ya NMN patsiku adatsimikiziridwa kuti ndi othandiza pakuwonjezera kuchuluka kwa NAD+ m'magazi, ndikuyerekeza ndi gulu la placebo anatenga NMN pamlomo anawonjezera mtunda wawo woyenda wa mphindi 6, ndipo kutenga NMN kwa masabata a 12 otsatizana kungapangitse kugona bwino, kupititsa patsogolo ntchito ya thupi, ndi kulimbitsa mphamvu za thupi, monga kuwonjezera mphamvu zogwira, kupititsa patsogolo liwiro la kuyenda, etc. Kumachepetsa kutopa ndi kugona, kumawonjezera mphamvu, etc.
Japan inali dziko loyamba kuchita mayesero a zachipatala a NMN, ndipo Keio University School of Medicine inayamba kuyesa kwachipatala kwa gawo lachiwiri mu 2017 atamaliza kuyesa kwachipatala kwa gawo loyamba kuti atsimikizire chitetezo. Kafukufuku wachipatala adachitidwa ndi Shinsei Pharmaceutical, Japan ndi Graduate School of Biomedical Sciences and Health, Hiroshima University. Phunziroli, lomwe linayamba mu 2017 kwa chaka chimodzi ndi theka, likufuna kuphunzira za thanzi la ntchito ya NMN ya nthawi yayitali.
Kwa nthawi yoyamba padziko lapansi, zatsimikiziridwa mwachipatala kuti kufotokoza kwa mapuloteni a moyo wautali kumawonjezeka pambuyo poyendetsa pakamwa pa NMN mwa anthu, ndipo kufotokozera kwa mitundu yosiyanasiyana ya mahomoni kumawonjezeka.
Mwachitsanzo, itha kuthandizidwa popititsa patsogolo kayendedwe ka mitsempha (neuralgia, etc.), kusintha kwa chitetezo chamthupi, kusintha kwa kusabereka mwa amuna ndi akazi, kulimbitsa minofu ndi mafupa, kusintha kwa mahomoni (kupititsa patsogolo kwa khungu), kuwonjezeka kwa melatonin (kuwongolera kugona), ndi kukalamba kwa ubongo chifukwa cha Alzheimer's, Parkinson's disease, ischemic encephalopathy ndi matenda ena.
Pakalipano pali kafukufuku wochuluka wofufuza zotsatira zotsutsana ndi ukalamba za NMN m'maselo osiyanasiyana ndi minofu. Koma ntchito zambiri zimachitika mu vitro kapena mu zitsanzo za nyama. Komabe, pali malipoti ochepa a anthu okhudzana ndi chitetezo cha nthawi yayitali komanso anti-aging clinic efficacy ya NMN mwa anthu. Monga momwe tingawonere kuchokera ku ndemanga yomwe ili pamwambayi, chiwerengero chochepa chabe cha maphunziro a preclinical ndi chipatala chafufuza chitetezo cha kayendetsedwe ka nthawi yaitali kwa NMN.
Komabe, pali kale zambiri za NMN zoletsa kukalamba pamsika, ndipo opanga akugulitsa mwachangu mankhwalawa pogwiritsa ntchito in vitro ndipo mu vivo zotsatira zake m'mabuku. Choncho, ntchito yoyamba iyenera kukhala kukhazikitsa toxicology, pharmacology, ndi mbiri ya chitetezo cha NMN mwa anthu, kuphatikizapo odwala ndi odwala matenda.
Zonsezi, zizindikiro zambiri ndi matenda a kuchepa kwa ntchito chifukwa cha "kukalamba" ali ndi zotsatira zabwino.
Nthawi yotumiza: May-21-2024
