N-Acetyl Carnosine: Antioxidant Yamphamvu Yomwe Imalimbikitsa Thanzi la Maso

N-Acetyl Carnosine (NAC) ndi chinthu chopangidwa mwachilengedwe chogwirizana ndi dipeptide carnosine. Mapangidwe a ma molekyulu a NAC ndi ofanana ndi carnosine kupatula kuti amanyamula gulu lina la acetyl. Acetylation imapangitsa NAC kukhala yolimba kwambiri pakuwonongeka ndi carnosinase, puloteni yomwe imaphwanya carnosine ku ma amino acid ake, beta-alanine ndi histidine.
Carnosine ndi zotumphukira za kagayidwe kachakudya za carnosine, kuphatikiza NAC, zimapezeka mumitundu yosiyanasiyana koma makamaka minofu ya minofu. Mankhwalawa ali ndi machitidwe osiyanasiyana monga owononga ma free radical scavengers.Akhala akunena kuti NAC imagwira ntchito kwambiri polimbana ndi lipid peroxidation m'madera osiyanasiyana a lens m'maso. Ndilo gawo la madontho a m'maso omwe amagulitsidwa ngati chakudya chowonjezera (osati mankhwala) ndipo adalimbikitsidwa kuti apewe ndi kuchiza matenda a ng'ala. Pali umboni wochepa pachitetezo chake, ndipo palibe umboni wokhutiritsa wosonyeza kuti mankhwalawa ali ndi mphamvu pa thanzi la maso.
Kafukufuku wambiri wachipatala pa NAC wachitidwa ndi Mark Babizhayev wa kampani ya US Innovative Vision Products (IVP), yomwe imagulitsa mankhwala a NAC.
Pa kuyesa koyambirira komwe kunachitika ku Moscow Helmholtz Research Institute for Eye Diseases, zidawonetsedwa kuti NAC (1% ndende), imatha kuchoka ku cornea kupita ku nthabwala zamadzi pambuyo pa mphindi 15 mpaka 30. Mu kuyesa kwa 2004 kwa maso 90 a canine okhala ndi ng'ala, NAC idanenedwa kuti idachita bwino kuposa placebo pokhudza kumveka bwino kwa lens. Kafukufuku woyambirira wa anthu NAC adanenanso kuti NAC inali yothandiza pakuwongolera masomphenya kwa odwala ng'ala ndikuchepetsa mawonekedwe a ng'ala.
Gulu la Babizhayev pambuyo pake linasindikiza kuyesa kwachipatala koyendetsedwa ndi placebo kwa NAC m'maso a anthu 76 okhala ndi ng'ala pang'onopang'ono komanso kutulutsa zotsatira zabwino zofananira za NAC. Komabe, kafukufuku wa sayansi wa 2007 wa mabuku omwe alipo panopa adakambirana za zofooka za mayesero a zachipatala, ponena kuti phunziroli linali ndi mphamvu zochepa zowerengera, chiwerengero chapamwamba chosiya ndi "chiwerengero chosakwanira choyambira kuyerekezera zotsatira za NAC", pomaliza kuti "chosiyana chachikulu. kuyesedwa kumafunika kuwonetsa phindu la chithandizo chanthawi yayitali cha NAC ”.
Babizhayev ndi anzake adasindikizanso kuyesa kwachipatala kwaumunthu mu 2009. Iwo adanena zotsatira zabwino za NAC komanso kutsutsana "njira zina zokha zomwe zinapangidwa ndi IVP ... ndizothandiza popewera ndi kuchiza matenda okalamba omwe amagwiritsidwa ntchito kwa nthawi yaitali."
N-acetyl carnosine yaphunziridwa chifukwa cha kuthekera kwake kuthandizira ma lens ndi thanzi la retina. Kafukufuku akuwonetsa kuti N-acetyl carnosine ikhoza kuthandizira kumveketsa bwino kwa lens (yofunikira kuti muwone bwino) ndikuteteza maselo osalimba a retina kuti asawonongeke. Izi zimapangitsa kuti N-acetyl carnosine ikhale yofunika kwambiri polimbikitsa thanzi la maso komanso kuteteza mawonekedwe.
Ngakhale kuti N-acetyl carnosine imasonyeza lonjezano pothandizira thanzi la maso, ndikofunika kuzindikira kuti kufufuza kwina kumafunika kuti mumvetse bwino zotsatira zake za nthawi yayitali komanso kuyanjana ndi mankhwala ena. Monga momwe zilili ndi zowonjezera kapena chithandizo chilichonse, tikulimbikitsidwa kukaonana ndi dokotala musanagwiritse ntchito N-acetyl carnosine, makamaka ngati muli ndi vuto la maso kapena mukumwa mankhwala ena.
Kuonjezera apo, poganizira zowonjezera ndi N-acetyl carnosine, ndikofunika kusankha mankhwala olemekezeka, apamwamba kwambiri kuti atsimikizire chiyero ndi mphamvu. Pali madontho a maso pamsika omwe ali ndi N-acetyl carnosine, ndipo kuti zotsatira zake zikhale zabwino kwambiri ndizofunika kutsatira mlingo woyenera ndi malangizo ogwiritsira ntchito.
Pomaliza, N-acetyl carnosine ndi mankhwala odalirika omwe ali ndi kuthekera kwakukulu kothandizira thanzi la maso, makamaka popewa ndi kuyang'anira matenda a maso okhudzana ndi ukalamba. Katundu wake wa antioxidant komanso kuthekera koteteza maso kupsinjika kwa okosijeni kumapangitsa kuti ikhale chida chofunikira poteteza magwiridwe antchito amaso komanso kukhala ndi thanzi lamaso. Pamene kafukufuku m'derali akupitirizabe kusintha, N-acetyl carnosine ikhoza kukhala chinthu chofunika kwambiri pakulimbikitsa ukalamba wathanzi komanso kukhala ndi masomphenya omveka bwino.