Ceramide ndi mtundu wa mankhwala a amide omwe amapangidwa ndi kutaya madzi m'thupi la mafuta amtundu wautali komanso gulu la amino la sphingomyelin, makamaka ceramide phosphorylcholine ndi ceramide phosphatidylethanolamine, phospholipids ndizo zigawo zikuluzikulu za maselo, ndi 40% -50% ya sebum. stratum corneum imakhala ndi ma ceramides, omwe ndi gawo lalikulu la matrix apakati-ma cell, ndikuchita nawo gawo lofunikira pakusunga bwino madzi a stratum corneum. Ceramide imakhala ndi mphamvu yomanga mamolekyu amadzi, ndipo imasunga chinyezi pakhungu popanga ma mesh mu stratum corneum. Chifukwa chake, ma ceramides amatha kusunga chinyezi pakhungu.
Ma Ceramides (Cers) amapezeka m'maselo onse a eukaryotic ndipo amagwira ntchito yofunika kwambiri pakuwongolera kusiyanitsa kwa ma cell, kuchulukana, apoptosis, ukalamba ndi zochitika zina zamoyo. Monga chigawo chachikulu cha intercellular lipids mu stratum corneum pakhungu, ceramide sikuti amachita ngati molekyulu yachiwiri ya mthenga mu njira ya sphingomyelin, komanso imagwira ntchito yofunika kwambiri pakupanga mapangidwe a epidermal stratum corneum, omwe amagwira ntchito yosunga. khungu chotchinga, moisturizing, anti-kukalamba, whitening, ndi matenda mankhwala.
Nazi mfundo zazikulu za ceramides:
Ntchito Yamapangidwe
Ceramides ndi gawo lalikulu la lipid bilayers mu cell membranes, ndipo amakhala ochuluka kwambiri kunja kwa khungu. Mu stratum corneum, ma ceramides amathandizira kupanga chotchinga chotchinga chomwe chimalepheretsa kutaya kwa madzi ndikuteteza khungu ku zonyansa zakunja.
Skin Barrier Function
The stratum corneum imagwira ntchito ngati chotchinga ku chilengedwe chakunja, ndipo mapangidwe a ceramides omwe ali mu gawoli ndi ofunikira kuti khungu likhale ndi mphamvu komanso kupewa kulowa kwa zinthu zovulaza. Kuperewera kwa ma ceramides kungayambitse khungu louma komanso kusokoneza ntchito yotchinga.
Ukalamba ndi Khungu
Miyezo ya ceramides pakhungu imacheperachepera ndi ukalamba, ndipo kuchepa kumeneku kumayenderana ndi mikhalidwe monga khungu louma ndi makwinya. Nthawi zina pakhungu, monga chikanga, psoriasis, ndi atopic dermatitis, pakhoza kukhala kusokonezeka kwa kapangidwe ka ceramide, zomwe zimapangitsa kuti izi zitheke.
Zodzoladzola ndi Dermatological Applications
Chifukwa cha gawo lawo paumoyo wapakhungu, ma ceramides nthawi zambiri amaphatikizidwa muzogulitsa zosamalira khungu. Kugwiritsa ntchito pamitu ma ceramides kumatha kuthandizira kubwezeretsa ndikusunga zotchingira pakhungu, zomwe zitha kupindulitsa anthu omwe ali ndi khungu louma kapena lowonongeka.
Mitundu ya Ceramides
Pali mitundu ingapo ya ceramides (yosankhidwa ndi manambala monga Ceramide 1, Ceramide 2, etc.), ndipo mtundu uliwonse uli ndi mawonekedwe osiyana pang'ono. Mitundu yosiyanasiyana ya ceramide iyi imatha kukhala ndi ntchito zapadera pakhungu.
Zakudya Zakudya
Ngakhale kuti ma ceramides amapangidwa makamaka m'thupi, kafukufuku wina amasonyeza kuti zakudya zina, monga sphingolipids zomwe zimapezeka muzakudya zina monga mazira, zingathandize kuti ceramide.
Nthawi yotumiza: Dec-12-2023
