Tartaric acid, yomwe imadziwikanso kuti 'kojic acid' kapena 'kojic acid', ndi chinthu chomwe chimapezeka mu soya msuzi, phala la soya, popanga moŵa wavinyo, ndipo amatha kupezeka muzinthu zambiri zofufumitsa zofufumitsa ndi Aspergillus.
Asayansi akale kwambiri anapeza kuti manja a akazi ogwira ntchito yopangira moŵa ndi oyera kwambiri. Pambuyo pophunzira za nayonso mphamvu, zidapezeka kuti sikuti zimangokhala ndi gawo labwino pakusunga kutsitsimuka kwa curvilinear acid. Ilinso ndi kuyera bwino komanso kuwunikira. Ngakhale, kamvekedwe ka khungu sikudetsa nkhawa. Ambiri a dermatologists a ku Ulaya ndi ku America amagwiritsa ntchito 2 mpaka 4% ya kojic acid kuti athetse chloasma mwa odwala awo ndi zotsatira zabwino.
Kojic acid imatha kuletsa ntchito ya tyrosinase ndikuletsa kupanga melanin. Kojic acid pamagulu a 20 μg/ml amatha kuletsa ntchito ya michere yambiri ya tyrosinase ndi 70% -80%. Mu zodzoladzola, tikulimbikitsidwa kuwonjezera 0.5% -2% ya tretinoin, yomwe ingalepheretse kupanga melanin ndikukwaniritsa zotsatira za kuyera ndi mawanga.
Kuphatikiza pa kuyera kwake, kojic acid imakhala ndi ma free radical scavenging komanso antioxidant katundu. Zitha kuthandiza khungu la astringent, kulimbikitsa kuphatikizika kwa mapuloteni komanso kumangitsa khungu. Sikuti ali ndi mankhwala enaake oletsa mabakiteriya, komanso ali ndi mphamvu zina zonyowa ndipo amatha kugwiritsidwa ntchito ngati chosungira chakudya ndi zodzoladzola. Kkojic asidi akhoza ziletsa ntchito ya hyaluronidase, kotero kuti akhoza ziletsa ziwengo.
Kojic acid, yofanana ndi VC, imamangiriza ku ayoni amkuwa ndikuyambitsa tyrosinase.
Kojic acid imalepheretsanso kupanga melanin oxidation intermediates. Kojic acid ndi okosijeni ndi dopaquinone wapakatikati, motero amachepetsa gawo lapansi la chain reaction ndikuletsa kutembenuka kwa melanin wapakatikati kuchokera ku dopaquinone kupita ku melanin yomaliza. M'munsi ndende amatha kupeza zotsatira zabwino zake zachiwawa zotsatira . Ndi chifukwa chakuti zotsatira zake zimakhala zolimba kwambiri zomwe zingayambitse khungu lofiira komanso kukhudzana ndi dermatitis. Chifukwa chake, ndichifukwa chake zinthu zambiri zoyera zimakhala ndi zowonjezera zochepa.
Ubwino wa kojic acid ndi kuyamwa kwakukulu kwa transdermal, kuletsa kwabwino kwa tyrosinase komanso kusakhala ndi cytotoxic. Itha kugwiritsidwa ntchito poyera, kuchotsa zilema, kukonza kamvekedwe ka khungu, ndi zina zambiri; ndipo imathanso kusunga madzi ndikuwonjezera kusungunuka kwa khungu.
Mukamagwiritsa ntchito kojic acid, ndi bwino kumvetsera mfundo zotsatirazi.
Choyamba, kojic acid idzalephera mu kuwala kowala kapena malo amphamvu acidic ndipo m'malo mwake amawonjezera melanin.
Chachiwiri, kupewa kugwiritsa ntchito salicylic acid, zipatso za zipatso, kuchuluka kwa VC ndi zinthu zina. Ndikosavuta kupititsa patsogolo khungu ndikugudubuza ndi kuwononga chotchingacho mwa stacking zowonjezera zowonjezera zowonjezera zomwe zimakwiyitsa kwambiri.Chachitatu, muyenera kuchita ma hydration amphamvu, tcherani khutu ku dzuwa kuti muteteze anti-wakuda.
Ngakhale kuti kojic acid ndi ace mu dzenje la dziko loyera, imayenera kugwiritsidwa ntchito mosamala ndi kugwiritsidwa ntchito moyenera kuti igwire ntchito yaikulu.
Nthawi yotumiza: Jun-08-2024
