M'badwo Wachitatu wa Carnosine Derivatives: N-acetyl carnosine

M'mbiri ya China, chisa cha mbalame chimatchedwa tonic, chomwe chimatchedwa "Oriental Caviar". Zalembedwa mu Materia Medica kuti chisa cha mbalame ndi "chitonthozo ndipo chimatha kutsukidwa, ndipo ndi mankhwala opatulika owongolera kuchepa ndi ntchito". N-Acetyl Neuraminic Acid ndizomwe zimapangira chisa cha mbalame, choncho amadziwikanso kuti chisa cha mbalame, ndipo zomwe zili mumtunduwu ndi chizindikiro cha zisa za mbalame.

N-acetyl carnosine (NAC) ndi mankhwala opangidwa mwachilengedwe okhudzana ndi dipeptide carnosine. Mapangidwe a molekyulu a NAC ndi ofanana ndi a carnosine kupatula kuti amanyamula gulu lina la acetyl. Acetylation imapangitsa NAC kukhala yolimba kwambiri pakuwonongeka ndi myostatin, puloteni yomwe imaphwanya myostatin kukhala ma amino acid β-alanine ndi histidine.

O-Acetyl Carnosine ndizochokera ku carnosine zomwe zimachitika mwachibadwa zomwe zinayamba kudziwika mu minofu ya kalulu mu 1975. Mwa anthu, acetyl carnosine imapezeka makamaka m'mafupa a mafupa, ndipo minofu ya minofu imatulutsa chigawocho pamene munthu akuchita masewera olimbitsa thupi.

Monga m'badwo wachitatu wa zotumphukira zachilengedwe za carnosine, acetyl carnosine imakhala ndi mphamvu zochulukirapo, kusinthika kwa acetylation kumapangitsa kuti zisadziwike komanso kuchepetsedwa ndi carnosine peptidase m'thupi la munthu, ndipo zimakhala ndi kukhazikika kwapamwamba. , anti-kutupa, etc.

Acetyl carnosine sikuti imangowonjezera kukhazikika, komanso imakhala ndi antioxidant komanso anti-yotupa zotsatira za carnosine.

Acetyl carnosine imakhala ndi zotsatira zambiri, osati kungosewera zolimbitsa thupi, zotsitsimula, zokometsera ndi zina zosamalira khungu, komanso zimalepheretsa mbadwo wa zowonongeka zowonongeka kwa okosijeni, zotupa, zakhala zikugwiritsidwa ntchito kwambiri pochiza zizindikiro za cataract za madontho a maso.

Acetyl carnosine imagwiritsidwanso ntchito nthawi zambiri muzodzoladzola kapena mankhwala osamalira.Mwachitsanzo, mankhwala osamalira khungu a nkhope, thupi, khosi, manja, ndi khungu la periocular; kukongola ndi zinthu zosamalira (monga mafuta odzola, AM/PM creams, seramu); antioxidants, zodzola pakhungu, kapena zonyowa mu zodzoladzola ndi zinthu zosamalira khungu; ndi machiritso owonjezera mu zodzola.

Mwachidule, monga zinthu zomwe zimachitika mwachilengedwe m'thupi la munthu, myostatin ndi zotumphukira zake zimakhala ndi chitetezo chokwanira kwambiri.