Igitangaza cyo kurwanya gusaza nicotinamide mononucleotide (NMN)

Kuva ibicuruzwa bya NMN byavuka, bimaze kumenyekana mwizina rya "elixir yo kudapfa" n "" imiti iramba ", kandi ububiko bwa NMN bujyanye nabwo bwashakishijwe nisoko. Li Ka-shing yari yarafashe NMN mu gihe runaka, hanyuma akoresha miliyoni 200 z'amadolari ya Hong Kong mu iterambere rya NMN, kandi isosiyete ya Warren Buffett nayo yagiranye ubufatanye bukomeye n'abakora NMN. NMN, itoneshwa nabakire bo hejuru, mubyukuri ishobora kugira ingaruka zo kuramba?

NMN ni nikotinamide mononucleotide (Nicotinamide mononucleotide), izina ryuzuye ni "β-nicotinamide mononucleotide", iri mu cyiciro cy’ibikomoka kuri vitamine B kandi ikaba ibanziriza NAD +, ishobora guhinduka muri NAD + binyuze mu bikorwa by’uruhererekane rwa enzymes. mumubiri, kubwibyo NMN inyongera ifatwa nkuburyo bwiza bwo kuzamura urwego rwa NAD +. NAD + ni urufunguzo rwibanze rwa coenzyme rufite uruhare rutaziguye mu magana ya metabolike, cyane cyane ibijyanye no kubyara ingufu. Mugihe tugenda dusaza, urwego rwa NAD + mumubiri rugabanuka buhoro buhoro. Kugabanuka kwa NAD + bizabangamira ubushobozi bwingirabuzimafatizo zitanga ingufu, kandi umubiri uzagira ibimenyetso byangirika nko kwangirika kwimitsi, gutakaza ubwonko, pigmentation, guta umusatsi, nibindi, bisanzwe bita "gusaza".

Nyuma yimyaka yo hagati, urwego rwa NAD + mumibiri yacu rugabanuka munsi ya 50% yurwego ruto, niyo mpamvu nyuma yimyaka runaka, biragoye gusubira mubuzima bwurubyiruko nubwo waruhuka bingana iki. Urwego rwa NAD + ruto rushobora kandi gutera indwara nyinshi ziterwa no gusaza, harimo nka aterosklerose, arthrite, umuvuduko ukabije w'amaraso, indwara z'umutima n'imitsi, kugabanuka kw'ubwenge, indwara zifata ubwonko, diyabete, na kanseri, n'ibindi.

Mu mwaka wa 2020, ubushakashatsi bw’umuryango w’ubumenyi kuri NMN mu byukuri bwari bugitangira, kandi ubushakashatsi hafi ya bwose bwari bushingiye ku bushakashatsi bw’inyamaswa n’imbeba, kandi igeragezwa ryonyine ry’amavuriro ry’abantu muri 2020 icyo gihe ryemeje gusa “umutekano” w’inyongera za NMN, kandi ntabwo yemeje ko urwego rwa NAD + mumubiri wumuntu rwiyongereye nyuma yo gufata NMN, kereka ko bishobora gutinda gusaza.

Noneho, nyuma yimyaka ine, hari iterambere rishya ryubushakashatsi muri NMN.

Mu isuzuma ry’iminsi 60 ry’amavuriro ryasohowe mu 2022 ku bagabo 80 bafite ubuzima buzira umuze hagati, amasomo afata 600-900mg ya NMN ku munsi yemejwe ko afite akamaro mu kongera urugero rwa NAD + mu maraso, ugereranije n’itsinda rya placebo, abayoboke yafashe NMN mu magambo yongereye umunota wabo urugendo rw'iminota 6, kandi gufata NMN ibyumweru 12 bikurikiranye bishobora kunoza ireme ryibitotsi, kunoza imikorere yumubiri, no kunoza imbaraga zumubiri, nko kongera imbaraga zo gufata, kunoza umuvuduko wo kugenda, nibindi. Kugabanya umunaniro no gusinzira, kwiyongera ingufu, n'ibindi

Ubuyapani nicyo gihugu cya mbere cyakoze ibizamini bya kliniki ya NMN, kandi Ishuri Rikuru ry’Ubuvuzi rya Keio ryatangiye icyiciro cya kabiri cy’amavuriro mu 2017 nyuma yo kurangiza icyiciro cya mbere cy’amavuriro kugira ngo umutekano ube. Ubushakashatsi bwa Clinical bwakozwe na Shinsei Pharmaceutical, Ubuyapani hamwe na Graduate School of Biomedical Science and Health, kaminuza ya Hiroshima. Ubushakashatsi bwatangiye muri 2017 umwaka nigice, bugamije kwiga ingaruka zubuzima bwo gukoresha NMN igihe kirekire.

Ku nshuro ya mbere ku isi, byemejwe mu buvuzi ko imvugo ya poroteyine yo kuramba yiyongera nyuma yo gutangwa mu kanwa kwa NMN mu bantu, kandi imvugo ya hormone zitandukanye nazo zikiyongera.

Kurugero, irashobora kuvurwa mugutezimbere imiyoboro yimitsi itwara imitsi (neuralgia, nibindi), kunoza ubudahangarwa, kunoza ubugumba kubagabo nabagore, gushimangira imitsi namagufwa, kunoza imisemburo ya hormone (kunoza imitekerereze) uruhu), kwiyongera kwa melatonine (kunoza ibitotsi), no gusaza k'ubwonko biterwa na Alzheimer's, indwara ya Parkinson, ischemic encephalopathie n'izindi ndwara.

Kuri ubu hari ubushakashatsi bwinshi bwo gucukumbura ingaruka zo kurwanya gusaza kwa NMN mu ngirabuzimafatizo zitandukanye. Ariko imirimo myinshi ikorerwa muri vitro cyangwa mubyitegererezo by'inyamaswa. Nyamara, hari raporo nke za rubanda ku bijyanye n’umutekano wigihe kirekire n’ingaruka zo kurwanya gusaza kwa NMN mu bantu. Nkuko bigaragara mubisubirwamo haruguru, umubare muto cyane wubushakashatsi bwibanze nubuvuzi bwakoze iperereza kumutekano wubuyobozi bwigihe kirekire bwa NMN.

Nyamara, hari isoko ryinshi rya NMN rirwanya gusaza ku isoko, kandi ababikora baracuruza cyane ibyo bicuruzwa bakoresheje vitro no mubisubizo bya vivo mubitabo. Kubwibyo, umurimo wambere ugomba kuba ugushiraho uburozi, farumasi, numwirondoro wumutekano wa NMN mubantu, harimo abarwayi bafite ubuzima bwiza nindwara.

Muri rusange, ibimenyetso byinshi n'indwara zo kugabanuka kumikorere biterwa no "gusaza" bifite ibisubizo bitanga icyizere.