N-Acetyl Carnosine: Antioxydants ikomeye iteza imbere ubuzima bwamaso

N-Acetyl Carnosine (NAC) ni ibintu bisanzwe biboneka muburyo bwa chimique bifitanye isano na dipeptide karnosine. Imiterere ya molekulari ya NAC isa na karnosine usibye ko itwara andi matsinda ya acetyl. Acetylation ituma NAC irwanya kwangirika kwa karnosinase, enzyme isenya karnosine kuri aside amine, beta-alanine na histidine.
Carnosine na metabolike ikomoka kuri karnosine, harimo na NAC, iboneka mubice bitandukanye ariko cyane cyane imitsi. Izi nteruro zifite ibikorwa bitandukanye nkibikorwa byubusa bya radical scavengers.Byavuzwe ko NAC ikora cyane cyane kurwanya lipide peroxidisation mu bice bitandukanye byinzira zijisho. Nibintu bigize ibitonyanga byamaso bigurishwa nkinyongera yimirire (ntabwo ari ibiyobyabwenge) kandi byatejwe imbere mukurinda no kuvura cataracte. Hano hari ibimenyetso simusiga ku mutekano wacyo, kandi nta bimenyetso bifatika byerekana ko uruganda rufite ingaruka ku buzima bwa ocular.
Ubushakashatsi bwinshi ku mavuriro kuri NAC bwakozwe na Mark Babizhayev wo muri sosiyete ikorera muri Amerika Innovative Vision Products (IVP), igurisha imiti ya NAC.
Mu bushakashatsi bwambere bwakorewe mu kigo cy’ubushakashatsi cy’indwara z’amaso cya Moscou Helmholtz, herekanywe ko NAC (concentration ya 1%), yashoboye kuva muri cornea ikajya mu rwenya rw’amazi nyuma yiminota 15 kugeza 30. Mu igeragezwa ryo mu 2004 ryakorewe amaso 90 ya kineine hamwe na cataracte, NAC yavuzwe ko yitwaye neza kurusha umwanya wa platbo muguhindura neza lens. Ubushakashatsi bwakozwe n'abantu hakiri kare NAC bwatangaje ko NAC yagize uruhare runini mu kunoza icyerekezo cy’abarwayi ba cataracte kandi igabanya isura y’indwara.
Itsinda rya Babizhayev nyuma ryasohoye igeragezwa ry’amavuriro ryagenzuwe na NAC mu maso y’abantu 76 ryoroheje kandi ryateye imbere kandi ryatangaje ibisubizo byiza kuri NAC. Icyakora, mu mwaka wa 2007 ubushakashatsi bwakozwe na siyansi y’ubuvanganzo buriho bwaganiriye ku mbogamizi z’ikigereranyo cy’amavuriro, buvuga ko ubushakashatsi bwari bufite imbaraga nke z’ibarurishamibare, umubare munini w’abata ishuri ndetse n '“ibipimo fatizo bidahagije kugira ngo ugereranye ingaruka za NAC”, basoza bavuga ko “binini bitandukanye ikigeragezo kirakenewe kugira ngo hagaragazwe inyungu zo kuvura NAC igihe kirekire ”.
Babizhayev na bagenzi be basohoye irindi suzuma ry’amavuriro ry’abantu mu mwaka wa 2009. Batangaje ko umusaruro ushimishije kuri NAC ndetse bakavuga ko “amata amwe n'amwe yateguwe na IVP… afite akamaro kanini mu gukumira no kuvura cataracte y’abasenateri kugira ngo ikoreshwe igihe kirekire.”
N-acetyl karnosine yakozweho ubushakashatsi kubushobozi bwayo bwo gushyigikira lens nubuzima bwa retina. Ubushakashatsi bwerekana ko N-acetyl karnosine ishobora gufasha kugumya kumvikanisha neza (ingirakamaro mu iyerekwa risobanutse) no kurinda ingirabuzimafatizo zangirika kwangirika. Izi ngaruka zituma N-acetyl karnosine igizwe ningirakamaro mugutezimbere ubuzima bwamaso muri rusange no kurinda imikorere yibikorwa.
Mugihe N-acetyl karnosine yerekana amasezerano yo gushyigikira ubuzima bwamaso, ni ngombwa kumenya ko hakenewe ubundi bushakashatsi kugirango dusobanukirwe neza ingaruka zigihe kirekire n’imikoranire ishobora kuba hamwe nindi miti. Kimwe ninyongera cyangwa ubuvuzi ubwo aribwo bwose, birasabwa kubaza inzobere mu buvuzi mbere yo gukoresha N-acetyl karnosine, cyane cyane niba ufite amaso cyangwa ukaba ufata indi miti.
Byongeye kandi, mugihe uteganya kuzuza N-acetyl karnosine, ni ngombwa guhitamo ibicuruzwa bizwi, byujuje ubuziranenge kugirango ube mwiza kandi neza. Hano hari isoko ryamaso kumasoko arimo N-acetyl karnosine, kandi kubisubizo byiza ni ngombwa gukurikiza dosiye yatanzwe hamwe namabwiriza yo gukoresha.
Mu gusoza, N-acetyl karnosine ni urugingo rutanga ikizere kandi rufite imbaraga nyinshi mu gushyigikira ubuzima bwamaso, cyane cyane mu gukumira no gucunga indwara ziterwa n’imyaka. Imiterere ya antioxydeant hamwe nubushobozi bwo kurinda amaso imbaraga za okiside itera igikoresho cyingirakamaro mukurinda imikorere yibikorwa no kubungabunga ubuzima bwamaso muri rusange. Mugihe ubushakashatsi muri kano karere bukomeje kugenda bwiyongera, N-acetyl karnosine irashobora kuba ikintu cyingenzi muguteza imbere gusaza neza no gukomeza icyerekezo gisobanutse kandi cyiza.