C. corneum ya stratum igizwe na ceramide, nigice cyingenzi cya matrice hagati ya selile, kandi ikina A Ifite uruhare runini mukubungabunga amazi ya stratum corneum. Ceramide ifite ubushobozi bukomeye bwo guhuza molekile zamazi, kandi igumana ubushuhe bwuruhu ikora imiterere mesh muri stratum corneum. Kubwibyo, ceramide ifite ubushobozi bwo kubungabunga ubushuhe bwuruhu.
Ceramide (Cers) iboneka muri selile zose za eukaryotic kandi igira uruhare runini mugutandukanya utugingo ngengabuzima, ikwirakwizwa, apoptose, gusaza nibindi bikorwa byubuzima. Nkibintu nyamukuru bigize lipide intercellular selile muri stratum corneum yuruhu, ceramide ntabwo ikora nka molekile ya kabiri yintumwa mumihanda ya sphingomyelin, ahubwo inagira uruhare runini mugikorwa cyo kwandura epidermal stratum corneum, ifite umurimo wo kubungabunga inzitizi y'uruhu, kuvomera, kurwanya gusaza, kwera, no kuvura indwara.
Hano hari ingingo z'ingenzi zerekeye ceramide:
Uruhare rwubaka
Ceramide nikintu kinini cyingenzi cya lipide bilayers muri selile, kandi ni nyinshi cyane mugice cyinyuma cyuruhu. Muri stratum corneum, ceramide ifasha gukora inzitizi ikingira irinda kubura amazi kandi ikarinda uruhu ibintu bitera hanze.
Imikorere y'uruhu
Corneum ya stratum ikora nk'inzitizi ku bidukikije byo hanze, kandi ibigize ceramide muri iki cyiciro ni ingenzi cyane mu kubungabunga uruhu no kwirinda kwinjiza ibintu byangiza. Kubura ceramide birashobora gutuma uruhu rwuma kandi rukabangamira imikorere ya barrière.
Gusaza hamwe nuruhu
Urwego rwa ceramide mu ruhu rukunda kugabanuka uko imyaka igenda ishira, kandi uku kugabanuka gufitanye isano nuruhu rwumye ndetse n’iminkanyari. Mubihe bimwe byuruhu, nka eczema, psoriasis, na atopic dermatitis, hashobora kubaho ihungabana mubigize ceramide, bikagira uruhare mubitera indwara.
Amavuta yo kwisiga hamwe na Dermatologiya
Urebye uruhare rwabo mubuzima bwuruhu, ceramide ikunze gushyirwa mubicuruzwa byuruhu. Gukoresha ingingo ya ceramide irashobora gufasha kugarura no gukomeza inzitizi yuruhu, birashobora kugirira akamaro abantu bafite uruhu rwumye cyangwa rwangiritse.
Ubwoko bwa Ceramide
Hariho ubwoko bwinshi bwa ceramide (yagenwe numubare nka Ceramide 1, Ceramide 2, nibindi), kandi buri bwoko bufite imiterere itandukanye gato. Ubu bwoko butandukanye bwa ceramide bushobora kugira imikorere yihariye muruhu.
Inkomoko y'ibiryo
Mu gihe ceramide ikorwa cyane cyane mu mubiri, ubushakashatsi bumwe bwerekana ko bimwe mu bigize imirire, nka sphingolipide iboneka mu biribwa bimwe na bimwe nk'amagi, bishobora kugira uruhare mu rwego rwa ceramide.
Igihe cyo kohereza: Ukuboza-12-2023
