Amateka ya vitamine B1
Vitamine B1 ni imiti ya kera, vitamine B ya mbere yavumbuwe.
Mu 1630, umuhanga mu bya fiziki w’Ubuholandi Jacobs · Bonites yasobanuye bwa mbere beriberi muri Java (icyitonderwa: ntabwo ari beriberi).
Mu myaka ya za 80 zo mu kinyejana cya 19, impamvu nyayo ya beriberi yavumbuwe bwa mbere n’Ubuyapani Navy.
Mu 1886, Dr. Christian · Ekmann, umuganga w’ubuvuzi mu Buholandi, yakoze ubushakashatsi ku bijyanye n’uburozi cyangwa mikorobe ifitanye isano na beriberi asanga inkoko zariye umuceri usukuye cyangwa wera zishobora gutera neurite, kandi kurya umuceri utukura cyangwa ibishishwa byumuceri bishobora gukumira cyangwa ndetse gukiza indwara.
Mu 1911, Dr. Casimir Funk, umuhanga mu by'imiti i Londres, yashizemo thiamine mu gihingwa cy'umuceri maze ayita “vitamine B1 ″.
Mu 1936, Williams na Cline11 basohoye uburyo bwa mbere bukwiye hamwe na synthesis ya vitamine B1.
Imikorere ya biohimiki ya vitamine B1
Vitamine B1 ni vitamine ikabura amazi idashobora guhuzwa n'umubiri kandi igomba gufatwa binyuze mu biryo cyangwa mu byongeweho.
Hariho uburyo butatu bwa vitamine B1 mu mubiri wumuntu, aribwo thiamine monophosphate, thiamine pyrophosphate (TPP) na thiamine triphosphate, muri zo TPP nuburyo nyamukuru buboneka kumubiri.
TPP ni cofactor ya enzymes nyinshi zigira uruhare mungufu za metabolisme, harimo na mitochondrial pyruvate dehydrogenase, α-ketoglutarate dehydrogenase, hamwe na cytosolike transketolase, byose bigira uruhare muri catabolisme ya karubone, kandi byose bikagaragaza ibikorwa byagabanutse mugihe cya thiamine.
Thiamine igira uruhare runini mu guhinduranya umubiri, kandi kubura thiamine bizatera igabanuka ry'umusaruro wa adenosine triphosphate (ATP), bikaviramo imbaraga za selile; Irashobora kandi kuzana kwirundanya kwa lakate, kubyara umusaruro wubusa, neuroexcitotoxicity, kubuza metabolisme ya myelin glucose no gukora aside amine acide amashami, hanyuma biganisha kuri apoptose.
Ibimenyetso byambere byo kubura vitamine B1
Kubura Thiamine kubera indyo yuzuye, malabsorption, cyangwa metabolism idasanzwe mubyiciro byambere cyangwa byambere.
Mu cyiciro cya kabiri, icyiciro cya biohimiki, ibikorwa bya transketolase byagabanutse cyane.
Icyiciro cya gatatu, icyiciro cya physiologique, cyerekana ibimenyetso rusange nko kugabanuka kwifunguro, kudasinzira, kurakara, no kurwara.
Mu cyiciro cya kane, cyangwa icyiciro cya clinique, ibimenyetso byinshi biranga kubura thiamine (beriberi), harimo claudication rimwe na rimwe, polyneuritis, bradycardia, edema periferique, kwaguka k'umutima, na ophaltmoplegia.
Icyiciro cya gatanu, icyiciro cya anatomiki, kirashobora kubona impinduka za histopathologique bitewe no kwangirika kwimiterere ya selile, nka hypertrophyi yumutima, cerebellar granule layer degeneration, hamwe no kubyimba mikorobe yubwonko.
Abantu bakeneye inyongera ya vitamine B1
Abakora imyitozo ngororamubiri igihe kirekire bakeneye vitamine B1 kugira ngo bagire uruhare mu gukoresha ingufu, kandi vitamine B1 ikoreshwa mu gihe cy'imyitozo.
Abantu banywa itabi, banywa, kandi barara igihe kirekire.
Abarwayi bafite indwara zidakira, cyane cyane abarwayi bafite indwara z'umutima-damura, diyabete, indwara zimpyiko, indwara zidakira zifata ibihaha, n'indwara zifata imyanya y'ubuhumekero.
Ku barwayi bafite umuvuduko ukabije w'amaraso, vitamine B1 nyinshi zitakara mu nkari kuko diuretique ikunze gukoreshwa ku barwayi bafite umuvuduko ukabije w'amaraso. Byongeye kandi, digoxine irashobora kandi kugabanya ubushobozi bwimitsi yimitsi yumutima kwinjiza no gukoresha vitamine B1.
Kwirinda gukoresha vitamine B1
1. Iyo ushyizwe mubipimo binini, kugena ubukana bwa serumu theophylline birashobora guhungabana, kugena aside irike irashobora kwiyongera kubeshya, kandi urobilinogen irashobora kuba nziza.
2. Vitamine B1 igomba gukoreshwa mbere yo guterwa glucose kugirango ivure encephalopathie ya Wernicke.
3. Vitamine B1 irashobora kuribwa mubiryo bisanzwe, kandi kubura monovitamine B1 ni gake. Niba ibimenyetso bidahagije, hitabwa kuri vitamine B igoye.
4. Ugomba gufatwa ukurikije dosiye isabwa, ntugakabye.
5. Baza umuganga cyangwa umufarumasiye kubana.
6. Abagore batwite n'abonsa bagomba gukoresha bayobowe na muganga.
7. Mugihe urenze urugero cyangwa ingaruka zikomeye, shakisha ubuvuzi bwihuse.
8. Abafite allergie kuri iki gicuruzwa barabujijwe, kandi abafite allergie bagomba gukoresha ubwitonzi.
9. Birabujijwe gukoresha iki gicuruzwa mugihe imitungo yacyo ihindutse.
10. Ntukagere kubana.
11. Abana bagomba kugenzurwa numuntu mukuru.
12. Niba ukoresha indi miti, nyamuneka ubaze umuganga wawe cyangwa umufarumasiye mbere yo gukoresha iki gicuruzwa.
Igihe cyo kohereza: Kanama-09-2024
