Kubva pakauya zvigadzirwa zveNMN, zvakave zvakakurumbira muzita re "elixir yekusafa" uye "hupenyu hurefu mushonga", uye zvine hukama NMN pfungwa masheya zvakatsvakwa zvakare nemusika. Li Ka-shing akanga atora NMN kwenguva yakati, ndokuzoshandisa mazana maviri emamiriyoni emadhora ekuHong Kong pakusimudzira NMN, uye kambani yaWarren Buffett yakasvikawo mukushandira pamwe nevagadziri veNMN. Ko NMN, iyo inofarirwa nevapfumi vepamusoro, ingave nehupenyu hurefu here?
NMN is nicotinamide mononucleotide (Nicotinamide mononucleotide), zita rakazara ndi "β-nicotinamide mononucleotide", iyo iri muchikamu chezvinotorwa nevhitamini B uye ndiyo inotangira NAD+, inogona kushandurwa kuita NAD+ kuburikidza nekuita kweakatevedzana ma enzymes. mumuviri, saka NMN yekuwedzera inoonekwa senzira inoshanda yekuvandudza NAD + mazinga. NAD + yakakosha intracellular coenzyme inobatanidzwa zvakananga mumazana emagetsi ekuita, kunyanya ayo ane chekuita nekugadzirwa kwesimba. Sezvo isu tichikura, NAD + mazinga ari mumuviri anodzikira zvishoma nezvishoma. Kudzikira kweNAD+ kuchakanganisa kugona kwemasero kuburitsa simba, uye muviri uchaona zviratidzo zvinodzikira zvakaita sekuderera kwemhasuru, kurasika kwehuropi, kupenya kwemavara, kudonha kwebvudzi, nezvimwewo, izvo zvinogara zvichinzi "kuchembera".
Mushure mezera repakati, iyo NAD + nhanho mumuviri wedu inodonha pasi pe50% yedanho rechidiki, ndosaka mushure meimwe zera, zvakaoma kudzokera kumamiriro ehudiki kunyangwe ukazorora zvakadii. Yakaderera NAD + mazinga anogona zvakare kutungamira kune dzakawanda zvirwere zvine chekuita nekuchembera, zvinosanganisira atherosclerosis, arthritis, high blood pressure, chirwere chemwoyo, kuderera kwekuziva, neurodegenerative chirwere, chirwere cheshuga, uye cancer, pakati pevamwe.
Muna 2020, tsvagiridzo yesaenzi yesaenzi paNMN yaive muhucheche, uye zvingangoita zvese zviedzo zvakavakirwa pakuedza kwemhuka nembeva, uye iyo chete yekiriniki yemunhu muyedzo muna 2020 panguva iyoyo yakangosimbisa "chengetedzo" yemuromo NMN yekuwedzera, uye haana kusimbisa kuti iyo NAD + nhanho mumuviri wemunhu yakawedzera mushure mekutora NMN, ndoda kuti inogona kunonoka kuchembera.
Zvino, makore mana gare gare, kune kumwe kutsva kwetsvakiridzo kufambira mberi muNMN.
Muyedzo yemazuva makumi matanhatu yekiriniki yakaburitswa muna 2022 pavarume makumi masere vepakati-kati vane hutano, zvidzidzo zvinotora 600-900mg yeNMN pazuva zvakasimbiswa kuti zvinoshanda mukuwedzera NAD+ mazinga muropa, uye zvichienzaniswa neboka re placebo, avo vanotora 600-900mg yeNMN pazuva. vakatora NMN nemuromo vakawedzera nhambwe yavo yekufamba kwemaminiti matanhatu, uye kutora NMN kwemavhiki gumi nemaviri akateedzana kunogona kuvandudza kunaka kwekurara, kuvandudza basa remuviri, uye kuvandudza simba remuviri, senge. kuwedzera simba rekubata, kuvandudza kukurumidza kufamba, etc. Inoderedza kuneta uye kurara, inowedzera simba, nezvimwewo.
Japan ndiyo yaive nyika yekutanga kuita NMN kiriniki miedzo, uye Keio University Chikoro cheMishonga chakatanga chikamu chechipiri chekuyedza kiriniki muna 2017 mushure mekupedza chikamu I chekiriniki yekuedza kuchengetedza kuchengetedzwa. Tsvagiridzo yekiriniki yekuyedza yakaitwa neShinsei Pharmaceutical, Japan uye Graduate Chikoro cheBiomedical Sayenzi uye Hutano, Hiroshima University. Chidzidzo, chakatanga muna 2017 kwegore nehafu, chinangwa chekudzidza nezvehutano hwekushandisa kwenguva refu NMN.
Kwenguva yekutanga munyika, yakave yakasimbiswa nekliniki kuti kutaura kweprotein yehupenyu hurefu hunowedzera mushure memuromo weNMN muvanhu, uye kutaura kwemarudzi akasiyana-siyana ehomoni kunowedzerawo.
Semuenzaniso, inogona kurapwa nekuda kwekuvandudzwa kwenerve conduction circuits (neuralgia, nezvimwewo), kuvandudzwa kwekudzivirira, kuvandudzwa kwekushaya mbereko muvarume nevakadzi, kusimbiswa kwemhasuru nemapfupa, kuvandudzwa kwehomoni (kuvandudzwa kwehomoni). ganda), kuwedzera kwe melatonin (kuvandudzwa kwehope), uye kuchembera kweuropi kunokonzerwa neAlzheimer's, Parkinson's disease, ischemic encephalopathy nezvimwe zvirwere.
Ikozvino kune tsvakurudzo yakawanda yekuongorora maitiro e-anti-aging eNMN mumasero akasiyana-siyana uye matishu. Asi mazhinji ebasa anoitwa in vitro kana mumhando dzemhuka. Zvisinei, kune mishumo mishoma yeruzhinji pamusoro pekuchengetedzwa kwenguva refu uye anti-aging kliniki efficacy yeNMN muvanhu. Sezvinogona kuonekwa kubva muongororo iri pamusoro, nhamba shomanana chete yezvidzidzo zvepreclinical uye zvekliniki zvakatsvaga kuchengetedzwa kwekutonga kwenguva refu kweNMN.
Nekudaro, kwatove neakawanda NMN anti-aging supplements pamusika, uye vagadziri vari kushingaira kushambadzira zvigadzirwa izvi vachishandisa in vitro uye mu vivo zvinobuda mumabhuku. Naizvozvo, basa rekutanga rinofanira kuve rekumisa iyo toxicology, pharmacology, uye chengetedzo chimiro cheNMN muvanhu, kusanganisira vane hutano uye varwere vane chirwere.
Zvose mune zvose, zviratidzo zvakawanda uye zvirwere zvekuderera kwebasa zvinokonzerwa ne "kukwegura" zvine migumisiro inovimbisa.
Nguva yekutumira: May-21-2024
