N-Acetyl Carnosine: Antioxidant Yakasimba Inosimudzira Utano Hweziso

N-Acetyl Carnosine (NAC) chinhu chinongoitika chega chemakemikari chine chekuita nedipeptide carnosine. Iyo NAC molecular chimiro chakafanana necarnosine kunze kwekuti inotakura imwe acetyl boka. Iyo acetylation inoita kuti NAC irambe ichidzivirirwa nekuderedzwa necarnosinase, enzyme inopwanya carnosine kune yayo inoumba amino acids, beta-alanine uye histidine.
Carnosine uye metabolic derivatives yecarnosine, kusanganisira NAC, inowanikwa mumhando dzakasiyana siyana asi kunyanya tsandanyama. Mishonga iyi ine madhigirii akasiyana ekuita semahara radical scavengers.Zvakanzi NAC inonyanya kurwisa lipid peroxidation munzvimbo dzakasiyana dzelenzi muziso. Icho chinhu chiri mumadonhwe emeso anotengeswa sechikafu chekuwedzera (kwete mushonga) uye akasimudzirwa kudzivirira uye kurapwa kwecataract. Pane humbowo hushoma pakuchengetedza kwayo, uye hapana humbowo hunogutsa hwekuti komboni ine chekuita neutano hwemaziso.
Ongororo zhinji yekiriniki yeNAC yakaitwa naMark Babizhayev wekambani yekuUS yeInnovative Vision Products (IVP), iyo inoshambadzira mishonga yeNAC.
Panguva yekuedza kwekutanga kwakaitwa kuMoscow Helmholtz Research Institute for Eye Diseases, zvakaratidzwa kuti NAC (1% concentration), yakakwanisa kupfuura kubva kucornea kuenda kune kuseka kwemvura mushure memaminitsi gumi nemashanu kusvika makumi matatu. Muna 2004 muyedzo we90 canine maziso ane cataracts, NAC yakanzi yakaita zvirinani pane placebo mukuita zvakanaka kujekesa lens. Chidzidzo chekutanga chevanhu NAC chakashuma kuti NAC yakashanda mukuvandudza maonero muvarwere vecataract uye yakaderedza kutaridzika kwecataract.
Boka reBabizhayev rakazoburitsa chirongwa chekiriniki chinodzorwa ne placebo cheNAC mumaziso evanhu makumi manomwe nenhanhatu vane kataratiti yakapfava kusvika kumberi uye yakashuma mhedzisiro yakafanana yeNAC. Zvisinei, ongororo yesayenzi ye2007 yezvinyorwa zvemazuva ano yakakurukura zvisingakwanisi kuongororwa kwekliniki, ichicherechedza kuti chidzidzo chacho chaiva nesimba rakaderera rehuwandu, chiyero chepamusoro chekusiya uye "kusakwana kwechiyero chekutanga chekuenzanisa mhedzisiro yeNAC", ichigumisa kuti "yakasiyana yakakura. muyedzo unodiwa kuratidza bhenefiti yenguva refu yeNAC kurapwa ”.
Babizhayev nevamwe vaaishanda navo vakaburitsa imwe ongororo yekiriniki yemunhu muna 2009. Vakataura mhedzisiro yakanaka yeNAC pamwe nekukakavadzana "dzimwe nzira dzakagadzirwa neIVP… dzinoshanda mukudzivirira nekurapa kwechirwere chegomarara chekushandisa kwenguva refu."
N-acetyl carnosine yakadzidzwa kuitira kugona kwayo kutsigira lens uye hutano hweretinal. Tsvagiridzo inoratidza kuti N-acetyl carnosine inogona kubatsira kuchengetedza kujeka kwelenzi (yakakosha pakuona kwakajeka) uye kudzivirira fragile retinal masero kubva mukukuvadzwa. Izvi zvinoita kuti N-acetyl carnosine ive musanganiswa wakakosha wekusimudzira hutano hweziso hwese uye kuchengetedza basa rekuona.
Kunyange zvazvo N-acetyl carnosine ichiratidza chivimbiso mukutsigira hutano hwemaziso, zvakakosha kuziva kuti imwe tsvakurudzo inodiwa kuti unzwisise zvizere migumisiro yayo yenguva refu uye kushamwaridzana kunogona kuitika nemimwe mishonga. Sezvinoita chero chekuwedzera kana kurapwa, zvinokurudzirwa kubvunza nyanzvi yezvehutano usati washandisa N-acetyl carnosine, kunyanya kana uine mamiriro emeso kana kutora mimwe mishonga.
Pamusoro pezvo, kana uchifunga nezvekuwedzera neN-acetyl carnosine, zvakakosha kuti usarudze chigadzirwa chine mukurumbira, chemhando yepamusoro kuti uve nechokwadi chekuchena uye kushanda. Pane madonhwe emaziso pamusika ane N-acetyl carnosine, uye kuti zvive nemigumisiro yakanaka zvakakosha kutevera chiyero chinokurudzirwa uye mirairo yekushandiswa.
Mukupedzisa, N-acetyl carnosine ikamu rinovimbisa rine simba guru mukutsigira hutano hwemaziso, kunyanya mukudzivirira nekugadzirisa zvirwere zvemaziso zvine chokuita nezera. Yayo antioxidant zvimiro uye kugona kuchengetedza maziso kubva kune oxidative kusagadzikana inoita kuti ive chishandiso chakakosha chekuchengetedza basa rekuona uye kuchengetedza hutano hwese hwemaziso. Sezvo tsvakurudzo munharaunda iyi iri kuramba ichishanduka, N-acetyl carnosine inogona kuva chinhu chinokosha mukusimudzira kukwegura kwakanaka uye kuchengetedza maonero akajeka, ane simba.