Nhoroondo yevhitamini B1
Vitamin B1 mushonga wekare, yekutanga B vhitamini kuwanikwa.
Muna 1630, muNetherlands physicist Jacobs · Bonites akatanga kutsanangura beriberi muJava (chinyorwa: kwete beriberi).
Mune 80s yezana ramakore rechi 19, chikonzero chaicho cheberiberi chakatanga kuwanikwa neJapan Navy.
Muna 1886, Dr. Christian · Ekmann, chiremba weNetherlands, akaita ongororo pamusoro pechepfu kana kuti microbial correlation yeberiberi uye akawana kuti huku dzinodya mupunga wakakwenenzverwa kana muchena dzingakonzera neuritis, uye kudya mupunga mutsvuku kana masanga emupunga kunogona kudzivirira kana kutoita. kurapa chirwere.
Muna 1911, Dr. Casimir Funk, nyanzvi yekemisitiri muLondon, akagadzira thiamine kubva mupunga remupunga ndokuitumidza kuti "vitamin B1".
Muna 1936, Williams naCline11 vakaburitsa yekutanga kuumbwa uye kuumbwa kwevhitamini B1.
Biochemical mabasa evhitamini B1
Vitamin B1 ivhitamini inonyungudika mumvura isingakwanise kugadzirwa nemuviri uye inoda kutorwa kuburikidza nechikafu kana kuwedzera.
Kune marudzi matatu evhitamini B1 mumuviri wemunhu, anoti thiamine monophosphate, thiamine pyrophosphate (TPP) uye thiamine triphosphate, iyo TPP ndiyo fomu huru inowanikwa kumuviri.
TPP ndeye cofactor yema enzymes akawanda anobatanidzwa musimba metabolism, kusanganisira mitochondrial pyruvate dehydrogenase, α-ketoglutarate dehydrogenase complex, uye cytosolic transketolase, iyo yose inobatanidzwa mu carbohydrate catabolism, uye iyo yose inoratidzira basa rakaderedzwa panguva yekushayikwa kwethiamine.
Thiamine inobata basa rakakosha mumetabolism yemuviri, uye kushomeka kwethiamine kunokonzera kuderera kwekugadzirwa kweadenosine triphosphate (ATP), zvichikonzera kushomeka kwesimba remagetsi; Inogona zvakare kuunza kuunganidzwa kwelactate, mahara radical kugadzirwa, neuroexcitotoxicity, inhibition yemyelin glucose metabolism uye kugadzirwa kwebranched-chain amino acids, uye pakupedzisira inotungamira kuapoptosis.
Zviratidzo zvekutanga zvekushaikwa kwevhitamini B1
Kushaikwa kweThiamine nekuda kwekudya kwakashata, malabsorption, kana kusagadzikana kwemasabolism muchikamu chekutanga kana chekutanga.
Muchikamu chechipiri, iyo biochemical nhanho, basa re transketolases rakaderedzwa zvakanyanya.
Danho rechitatu, danho rekuita muviri, rinoratidza zviratidzo zvakajairika sekuderera kwechido, kushaya hope, kushatirwa, uye malaise.
Muchikamu chechina, kana kuti chirwere chekiriniki, zviratidzo zvakasiyana-siyana zvekushaya thiamine (beriberi) zvinoonekwa, kusanganisira claudication, polyneuritis, bradycardia, peripheral edema, cardiac enlargement, uye ophthalmoplegia.
Nhanho yechishanu, iyo anatomical nhanho, inogona kuona histopathological shanduko nekuda kwekukuvadzwa kwemaserura zvimiro, senge cardiac hypertrophy, cerebellar granule layer degeneration, uye cerebral microglial kuzvimba.
Vanhu vanoda vitamin B1 supplementation
Yenguva refu-yakakwirira-yakasimba maekisesaizi inoda vhitamini B1 kuti itore chikamu mukushandiswa kwesimba, uye vhitamini B1 inoshandiswa panguva yekurovedza muviri.
Vanhu vanosvuta, vanonwa, uye vanononoka kurara kwenguva yakareba.
Varwere vane zvirwere zvisingaperi, kunyanya varwere vane chirwere chemwoyo, chirwere cheshuga, chirwere chetsvo, chirwere chisingaperi chemapapu, uye zvirwere zvinowanzoitika zvekufema.
Mune varwere vane high blood pressure, huwandu hwakawanda hwevhitamini B1 hunorasika muweti nokuti diuretics inowanzoshandiswa kune varwere vane high blood pressure. Mukuwedzera, digoxin inogonawo kuderedza kukwanisa kwemasero emwoyo mhasuru kutora uye kushandisa vhitamini B1.
Kuchengetedza kwekushandiswa kwevhitamini B1
1. Kana ikashandiswa mumatareji makuru, kusarudzwa kweserum theophylline concentration inogona kuvhiringidzika, kugadziriswa kweuric acid concentration kunogona kuwedzera nhema, uye urobilinogen inogona kuva yenhema yakanaka.
2. Vitamin B1 inofanira kushandiswa pamberi pejekiseni reglucose kuitira kurapwa kweWernicke's encephalopathy.
3. Vhitamini B1 inogona kudyiwa kubva mukudya zvakajairika, uye kushomeka kwemonovitamin B1 hakuwanzo. Kana zviratidzo zvisina kukwana, B-complex vhitamini inosarudzwa.
4. Inofanira kutorwa maererano neinokurudzirwa dosage, usapfuudza.
5. Bvunza chiremba kana wemishonga wevana.
6 . Vakadzi vane pamuviri uye vanoyamwisa vanofanira kushandisa pasi pekutungamirirwa kwachiremba.
7. Kana ukawandisa kana kuti zvinhu zvanyanya kuipa, tsvaga kurapwa nekukurumidza.
8. Avo vane allergic kune chigadzirwa ichi vanorambidzwa, uye avo vane allergies vanofanira kushandisa nekuchenjerera.
9. Zvinorambidzwa kushandisa chigadzirwa ichi kana zvinhu zvayo zvichichinja.
10. Chengetedza pasingasvikirwi nevana.
11. Vana vanofanira kutariswa nemunhu mukuru.
12. Kana uri kushandisa mamwe mishonga, tapota bvunza chiremba wako kana wemishonga usati washandisa chigadzirwa ichi.
Nguva yekutumira: Aug-09-2024
