Function
Antifibrinolytic Action: Inhibition of Plasmin Formation: Tranexamic acid inhibits the activation of plasminogen to plasmin, an enzyme crucial for the breakdown of blood clots. By preventing excessive fibrinolysis, TXA helps maintain the stability of blood clots.
Hemostatic Effects:
Bleeding Control: TXA is widely used in medical settings, especially during surgeries, trauma, and procedures with a risk of significant blood loss. It promotes hemostasis by reducing bleeding and preventing the premature dissolution of blood clots.
Management of Hemorrhagic Conditions:
Menstrual Bleeding: Tranexamic acid is employed to address heavy menstrual bleeding (menorrhagia), providing relief by reducing excessive blood loss during menstrual periods.
Dermatological Applications:
Hyperpigmentation Treatment: In dermatology, TXA has gained popularity for its ability to inhibit melanin synthesis and reduce hyperpigmentation. It is used in topical formulations to address conditions such as melasma and other forms of skin discoloration.
Reduction of Surgical Blood Loss:
Surgical Procedures: Tranexamic acid is often administered before and during certain surgeries to minimize bleeding, making it particularly useful in orthopedic and cardiac procedures.
Traumatic Injuries: TXA is employed in the management of traumatic injuries to control bleeding and improve outcomes in critical care settings.
CERTIFICATE OF ANALYSIS
Product Name |
Tranexamic Acid |
MF |
C8H15NO2 |
Cas No. |
1197-18-8 |
Manufacture Date |
2024.1.12 |
Quantity |
500KG |
Analysis Date |
2024.1.19 |
Batch No. |
BF-240112 |
Expiry Date |
2026.1.11 |
Items |
Specifications |
Results |
|
Appearance |
White or almost white, crystalline powder |
White crystalline powder |
|
Solubility |
Freely soluble in water, and practically insoluble in ethanol (99.5%) |
Complies |
|
Identification |
Infrared absorption atlas consistent with the contrast atlas |
Complies |
|
pH |
7.0 ~ 8.0 |
7.38 |
|
Related substances ( Liquid chromatography) % |
RRT 1.5 / Impurity with RRT 1.5: 0.2 max |
0.04 |
|
RRT 2.1 / Impurity with RRT 2.1 :0.1 max |
Not detected |
||
Any other impurity: 0.1 max |
0.07 |
||
The total impurites : 0.5 max |
0.21 |
||
Chlorides ppm |
140 max |
Complies |
|
Heavy metals ppm |
10 max |
<10 |
|
Arsenic ppm |
2 max |
< 2 |
|
Loss on drying % |
0.5 max |
0.23 |
|
Sulphated Ash % |
0. 1 max |
0.02 |
|
Assay % |
98 .0 ~ 101 |
99.8% |
|
Conclusion |
Complies with JP17 Specifications |