Ubonelelo lweFactory Succinic Acid Amber Acid Cas 110-15-6

I-Succinic acid yi-dicarboxylic acid ene-chemical formula (CH2) 2 (CO2H) 2. Igama livela kwi-Latin succinum, elithetha i-amber. Kwizinto eziphilayo, i-asidi ye-succinic ithatha imo yeanion, i-succinate, enendima ezininzi zebhayoloji njengento ephakathi ye-metabolic eguqulwa ibe yifumarate yi-enzyme succinate dehydrogenase kwi-complex 2 yekhonkco lokuthutha i-electron ebandakanyeka ekwenzeni i-ATP, kwaye njengoko imolekyuli yomqondiso ebonisa imeko ye-metabolic yeselula. I-Succinate iveliswa kwi-mitochondria ngomjikelezo we-tricarboxylic acid (TCA), inkqubo yokuvelisa amandla ekwabelwana ngazo zonke izinto eziphilayo. I-Succinate inokuphuma kwi-matrix ye-mitochondrial kwaye isebenze kwi-cytoplasm kunye nesithuba esingaphandle kwe-extracellular, iguqula iipateni zokubonisa i-gene, i-modulating landscape ye-epigenetic okanye ukubonisa ukubonakaliswa okufana ne-hormone. Ngaloo ndlela, i-succinate idibanisa i-metabolism yeselula, ngakumbi ukubunjwa kwe-ATP, kulawulo lomsebenzi weselula. I-Dysregulation ye-succinate synthesis, kwaye ngoko ke i-ATP synthesis, iyenzeka kwezinye izifo ze-mitochondrial zofuzo, ezifana ne-Leigh syndrome, kunye ne-Melas syndrome, kwaye ukuthotywa kunokukhokelela kwiimeko ze-pathological, ezifana nokuguqulwa okubi, ukuvuvukala kunye nokulimala kwezicubu.