Kwiminyaka yakutshanje, ukusetyenziswa kwe-monobenzone njenge-ejenti yokukhupha isikhumba kuye kwavusa ingxoxo enkulu phakathi kwezonyango kunye noluntu lwe-dermatological. Ngelixa abanye bechazwa njengonyango olusebenzayo lweemeko ezifana ne-vitiligo, abanye baphakamisa iinkxalabo malunga nokhuseleko lwayo kunye neziphumo ebezingalindelekanga ezinokubakho.
I-Monobenzone, ekwabizwa ngokuba yi-monobenzyl ether ye-hydroquinone (MBEH), i-ejenti yokukhupha i-pigmenting esetyenziselwa ukukhanyisa ulusu ngokutshabalalisa ngokusisigxina i-melanocytes, iiseli ezinoxanduva lokuvelisa i-melanin. Le propati ibangele ukusetyenziswa kwayo kunyango lwe-vitiligo, imeko yesikhumba engapheliyo ebonakaliswe ngokulahleka kwe-pigmentation kwiipatches.
Abaxhasi be-monobenzone bathi inokunceda abantu abane-vitiligo ukuba bafezekise ithoni efanayo yesikhumba ngokususa umbala kwindawo engachaphazelekiyo ukuze ihambelane namabala amdaka. Oku kunokuphucula ukubonakala ngokubanzi kunye nokuzithemba kwabo bachaphazelekayo yimeko, enokuthi ibe nempembelelo enkulu kumgangatho wobomi babo.
Nangona kunjalo, ukusetyenziswa kwe-monobenzone akukho mpikiswano. Abagxeki babhekisela kwimiphumo enokubakho kunye neenkxalabo zokhuseleko ezinxulumene nokusetyenziswa kwayo. Enye yezona zinto ziphambili ezixhalabisayo kumngcipheko we-depigmentation engenakuguqulwa, njengoko i-monobenzone itshabalalisa ngokusisigxina i-melanocytes. Oku kuthetha ukuba xa i-depigmentation isenzeka, ayikwazi ukuguqulwa, kwaye ulusu luya kuhlala lulula kwezo ndawo ngokungenasiphelo.
Ukongeza, kukho idatha yexesha elide elilinganiselweyo malunga nokhuseleko lwe-monobenzone, ngakumbi malunga ne-carcinogenicity enokubakho kunye nomngcipheko wobuntununtunu kunye nokucaphuka kwesikhumba. Olunye uphando lucebise ukuba kukho unxibelelwano olunokwenzeka phakathi kokusetyenziswa kwe-monobenzone kunye nomngcipheko okhulayo womhlaza wolusu, nangona uphando oluninzi luyafuneka ukuze kuqinisekiswe ezi ziphumo.
Ngaphaya koko, impembelelo yengqondo yonyango lwe-depigmentation kunye ne-monobenzone akufunekanga ingahoywa. Ngelixa ingaphucula inkangeleko yolusu oluchatshazelwe yi-vitiligo, inokukhokelela kwiimvakalelo zokuphulukana nesazisi kunye nokubekelwa ibala ngokwenkcubeko, ngakumbi kwiindawo apho ibala lolusu ludityaniswe ngokunzulu nobuni kunye nokwamkelwa eluntwini.
Ngaphandle kwezi nkxalabo, i-monobenzone iyaqhubeka ukusetyenziswa kunyango lwe-vitiligo, nangona ngononophelo kunye nokubekwa kweliso olusondeleyo kwiziphumo ezibi. Iingcali zeDermatologists kunye nababoneleli bezempilo bagxininisa ukubaluleka kwemvume enolwazi kunye nemfundo yesigulana ngokucokisekileyo xa kuqwalaselwa unyango lwe-monobenzone, ukuqinisekisa ukuba abantu bayayiqonda zombini inzuzo enokubakho kunye neengozi ezinxulumene nokusetyenziswa kwayo.
Ukuqhubela phambili, uphando olongezelelweyo luyafuneka ukuqonda ngcono ukhuseleko lwexesha elide kunye nokusebenza kwe-monobenzone, kunye nefuthe layo kwimpilo yengqondo yezigulane. Okwangoku, oogqirha kufuneka balinganise izibonelelo ezinokuthi zibekho kunye nobungozi bonyango lwe-monobenzone kwimeko-nge-case, kuthathelwa ingqalelo iimeko ezizodwa kunye nezinto ezikhethwa yisigulane ngasinye.
Ukuququmbela, ukusetyenziswa kwe-monobenzone njenge-agent ye-skin-depigmenting ihlala ingumxholo wengxoxo kunye neengxabano phakathi koluntu lwezonyango. Nangona inokubonelela ngeenzuzo kubantu abane-vitiligo, inkxalabo malunga nokhuseleko lwayo kunye nemiphumo yexesha elide igxininisa imfuneko yokuqwalaselwa ngononophelo kunye nokubeka iliso xa usebenzisa le arhente kwimisebenzi yezonyango.
Ixesha lokuposa: Mar-09-2024
