I-N-Acetyl Carnosine: I-Antioxidant enamandla eKhuthaza iMpilo yamehlo

I-N-Acetyl Carnosine (NAC) yinto eyenzeka ngokwemvelo ngokwemichiza enxulumene nedipeptide carnosine. Isakhiwo se-molecular ye-NAC siyafana ne-carnosine ngaphandle kokuba ithwala iqela elongezelelweyo le-acetyl. I-acetylation yenza i-NAC ixhathise ngakumbi ekuthotyweni yi-carnosinase, i-enzyme eyaphula i-carnosine kwizinto zayo ze-amino acids, i-beta-alanine kunye ne-histidine.
I-Carnosine kunye ne-metabolic derivatives ye-carnosine, kuquka i-NAC, ifumaneka kwiintlobo ezahlukeneyo zezicubu kodwa ngokukodwa izicubu zomzimba. Ezi zixhobo zinemigangatho eyahlukeneyo yomsebenzi njenge-scavengers ye-radical yamahhala.Kuye kwacetyiswa ukuba i-NAC isebenze ngokukodwa ngokuchasene ne-lipid peroxidation kwiindawo ezahlukeneyo ze-lens kwiso. Sisithako kumathontsi wamehlo athe athengiswa njengezongezelelo zokutya (kungekhona iyeza) kwaye ziye zakhuthazwa ukuthintela kunye nokunyangwa kwe-cataract. Kukho ubungqina obuncinane kukhuseleko lwayo, kwaye akukho bungqina bubambekayo bokuba ikhompawundi inefuthe kwimpilo yamehlo.
Uninzi lophando lweklinikhi kwi-NAC luqhutywe nguMark Babizhayev we-US-based company Innovative Vision Products (IVP), ethengisa unyango lwe-NAC.
Ngexesha lovavanyo lokuqala olwenziwe kwi-Moscow Helmholtz Research Institute for Eye Diseases, kwaboniswa ukuba i-NAC (i-1% yoxinaniso), yakwazi ukudlula kwi-cornea ukuya kwi-humor yamanzi emva kwemizuzu eyi-15 ukuya kwe-30. Kulingo lwe-2004 lwamehlo angama-90 e-canine ane-cataract, i-NAC yabikwa ukuba yenze ngcono kune-placebo ekuchaphazela ngokufanelekileyo ukucaca kwelensi. Uphononongo lwabantu bokuqala i-NAC yabika ukuba i-NAC yayisebenza kakuhle ekuphuculeni umbono kwizigulane ze-cataract kwaye yanciphisa ukubonakala kwe-cataract.
Iqela le-Babizhayev kamva lapapasha uvavanyo lweklinikhi olulawulwa yi-placebo lwe-NAC kumehlo angama-76 omntu anobuncinci ukuya kwi-cataracts ephezulu kwaye ichaze iziphumo ezifanayo ezifanayo ze-NAC. Nangona kunjalo, uphononongo lwezesayensi lwe-2007 loncwadi lwangoku luxubushe imida yovavanyo lweklinikhi, luphawula ukuba uphononongo lunamandla asezantsi ezibalo, izinga eliphezulu lokuyeka kunye "nomlinganiselo onganelanga wokuthelekisa umphumo we-NAC", ukugqiba ukuba "inkulu eyahlukileyo. ulingo luyafuneka ukuthethelela inzuzo yonyango lwexesha elide lwe-NAC”.
U-Babizhayev kunye noogxa bapapashe olunye ulingo lwezonyango lomntu ngo-2009. Banike ingxelo ngeziphumo ezincomekayo ze-NAC kunye nokuxoxa "kuphela iifomula ezithile eziyilwe yi-IVP… ezisebenzayo kuthintelo nakunyango lwe-senile cataract ukuze lusetyenziswe ixesha elide."
I-N-acetyl carnosine ifundwe ngamandla ayo okuxhasa i-lens kunye nempilo ye-retinal. Uphando lubonisa ukuba i-N-acetyl carnosine inokunceda ukugcina ukucaca kwe-lens (ibalulekile kumbono ocacileyo) kunye nokukhusela iiseli ze-retinal ezibuthathaka emonakalweni. Ezi ziphumo zenza i-N-acetyl carnosine ibe yinto ebalulekileyo yokukhuthaza impilo yamehlo ngokubanzi kunye nokukhusela umsebenzi obonakalayo.
Nangona i-N-acetyl carnosine ibonisa isithembiso ekuxhaseni impilo yamehlo, kubalulekile ukuqaphela ukuba uphando olongezelelweyo luyafuneka ukuze uqonde ngokupheleleyo imiphumo yayo yexesha elide kunye nokusebenzisana okunokwenzeka kunye namanye amayeza. Njengayo nayiphi na isongezelelo okanye unyango, kuyacetyiswa ukuba udibane nochwepheshe bezempilo ngaphambi kokusebenzisa i-N-acetyl carnosine, ngakumbi ukuba uneemeko zamehlo okanye uthatha amanye amayeza.
Ukongezelela, xa uqwalasela ukuxhaswa nge-N-acetyl carnosine, kubalulekile ukukhetha imveliso ehloniphekileyo, ekumgangatho ophezulu wokuqinisekisa ubunyulu kunye nokusebenza kakuhle. Kukho amathontsi emehlo kwimarike equkethe i-N-acetyl carnosine, kwaye ngeziphumo ezingcono kubalulekile ukulandela idosi ecetyiswayo kunye nemiyalelo yokusetyenziswa.
Ukuqukumbela, i-N-acetyl carnosine iyikhompawundi ethembisayo enamandla amakhulu ekuxhaseni impilo yamehlo, ngokukodwa ekukhuselweni nasekulawuleni izifo zamehlo ezinxulumene nobudala. Iimpawu zayo ze-antioxidant kunye nokukwazi ukukhusela amehlo kuxinzelelo lwe-oxidative kwenza kube sisixhobo esibalulekileyo sokukhusela umsebenzi obonakalayo kunye nokugcina impilo yamehlo ngokubanzi. Njengoko uphando kule ndawo luqhubeka nokuguquka, i-N-acetyl carnosine ingaba yinto ephambili ekukhuthazeni ukuguga okunempilo kunye nokugcina umbono ocacileyo, ophilileyo.