Kwiminyaka yakutshanje, i-Nicotinamide Mononucleotide (NMN) iye yavela njengento edibeneyo kwindawo yokulwa nokuguga kunye nempilo ye-metabolic. Njengoko izazinzulu ziphengulula kubunzima bokuguga kweselula kunye nemetabolism, i-NMN igqame njengento enokubakho yokutshintsha umdlalo kunye neziphumo ezibalulekileyo kubomi obude kunye nokuba sempilweni jikelele. Eli nqaku liphonononga ukuba yintoni i-NMN, iinzuzo zayo ezinokubakho, kunye nendima yayo kwikamva lempilo nokuba sempilweni.
Yintoni iNicotinamide Mononucleotide?
I-Nicotinamide Mononucleotide yi-nucleotide eyenzeka ngokwemvelo ephuma kwi-nicotinamide, uhlobo lwe-vitamin B3 (niacin). Idlala indima ebalulekileyo ekuvelisweni kweNicotinamide Adenine Dinucleotide (NAD+), i-coenzyme eyimfuneko kwiinkqubo ezininzi zebhayoloji. I-NAD + ibandakanyeka kwimveliso yamandla eselula, ukulungiswa kweDNA, kunye nokulawulwa kweendlela zemetabolism.
Njengoko siguga, amanqanaba e-NAD + ayehla, anxulunyaniswa neemeko ezahlukeneyo ezinxulumene nobudala kunye nokuphazamiseka kwemetabolism. Uncediso lwe-NMN kucingelwa ukuba luchase oku kuhla ngokunyusa amanqanaba e-NAD+, okunokubakho ukunika uluhlu lweenzuzo zempilo.
Inzululwazi ngasemvaNMN
Umsebenzi ophambili we-NMN kukusebenza njenge-precursor ye-NAD+, ebaluleke kakhulu ekusebenzeni ngokufanelekileyo kweenkqubo zeselula. I-NAD + ibalulekile kwimveliso yamandla ngaphakathi kwe-mitochondria, izindlu zamandla zeeseli. Ikwadlala indima ekwenzeni i-sirtuins isebenze, iqela leeprotheyini ezidityaniswe nobomi obude kunye nolawulo lwe-metabolic.
Uphando lubonise ukuba ukunyuka kwamanqanaba e-NAD+ ngokuncediswa kwe-NMN kunokuba nefuthe elihle kwiinkalo ezininzi zempilo. Izifundo zezilwanyana zibonisa ukuba i-NMN inokuphucula ukusebenza kwe-metabolic, ikhulise ukunyamezela komzimba, kunye nokukhuthaza impilo engcono yokuqonda. Nangona izifundo zabantu zisavela, idatha yokuqala iyathembisa.
Uncedo olunokubakho lwe-NMN
Iziphumo zokuchasa ukuguga:Ngokunyusa amanqanaba e-NAD+, i-NMN inokunceda ukulwa neziphumo zokuguga. Uphononongo lubonise ukuba amanqanaba aphezulu e-NAD+ anokuxhasa iindlela zokulungisa iiseli, ukuphucula ukusebenza kwe-mitochondrial, kunye nokunciphisa uxinzelelo lwe-oxidative, ebalulekileyo ekugcineni amandla olutsha.
Impilo yeMetabolic: NMNiye yadityaniswa nomsebenzi ophuculweyo we-metabolic, kubandakanywa ukulawulwa kwe-glucose engcono kunye nokuphucula uvakalelo lwe-insulin. Oku kunokuba luncedo ngakumbi kubantu abalawula ukuphazamiseka kwe-metabolic okanye abo basemngciphekweni wokuba nesifo seswekile esi-2.
Ukwenziwa koMzimba owomeleziweyo:Uphando lucebisa ukuba ukuxhaswa kwe-NMN kunokuphucula ukunyamezela komzimba kunye namandla omzimba. Oku kuneempembelelo kubadlali kunye nabadala abadala abafuna ukugcina amanqanaba okusebenza ngokomzimba kunye nokufaneleka ngokupheleleyo.
Umsebenzi wokuqonda:Uphononongo lwakwangoko lubonisa ukuba i-NMN inokuxhasa impilo yobuchopho kunye nokusebenza kwengqondo. Ngokunyusa amanqanaba e-NAD+, i-NMN inokubanakho ukomeleza inkumbulo, ukufunda, kunye nokusebenza kwengqondo kukonke.
Iindlela zeMarike kunye noPhando lwexesha elizayo
Umdla okhulayo kwi-NMN ukhokelele ekwandeni kokufumaneka kwayo njengesongezelelo sokutya. Njengoko abathengi befuna iindlela ezintsha zokuxhasa impilo kunye nokuphila ixesha elide, i-NMN iye yafumana ukuthandwa ngokukhawuleza. Nangona kunjalo, kubalulekile kubasebenzisi abanokubakho ukuba bahlale benolwazi malunga nophando lwamva nje kwaye badibane neengcali zezempilo ngaphambi kokuba baqalise nayiphi na irejimeni entsha yokongeza.
Uphando lwexesha elizayo luya kubaluleka ekuqinisekiseni iinzuzo zexesha elide kunye nokhuseleko lwe-NMN. Ulingo lwezonyango luyaqhubeka ukuqonda ngcono iziphumo zalo kwimpilo yabantu kunye nendima enokubakho ekuthinteleni izifo ezinxulumene nobudala. Njengoko uluntu lwezenzululwazi luqhubeka nokuphanda, i-NMN inokuba lilitye lembombo kusukelo lokuguga okunempilo kunye nempilo ye-metabolic.
Ukuqukumbela
Nicotinamide Mononucleotideimele ukuqhubela phambili okubonakalayo kwinkalo yempilo kunye nokuba sempilweni, ibonelela ngeenzuzo ezinokubakho ukusuka kwiziphumo zokuchasana nokuguga ukuya kuphuculo lokwenziwa kwemetabolism. Njengoko uphando luqhubela phambili, i-NMN inokuba ngumdlali ophambili kwiinzame zethu zokuphucula umgangatho wobomi kunye nobomi obude. Okwangoku, isithembiso sayo sigxininisa ukubaluleka kokuqhubeka nokuphononongwa kunye nokuqonda ekufuneni impilo engcono kunye nokuphila kakuhle.
Iinkcukacha zoqhakamshelwano:
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Ixesha lokuposa: Sep-12-2024
