I-NMN – C11H15N2O8P yimolekyuli ekhoyo ngokwendalo kuzo zonke iintlobo zobomi.

I-NMN (igama elipheleleyo i-β-nicotinamide mononucleotide) - "i-C11H15N2O8P" yi-molecule eyenzeka ngokwemvelo kuzo zonke iintlobo zobomi. Le nucleotide yendalo ephilayo yinto ephambili kwimveliso yamandla kwaye iyafuneka kwiinkqubo ezahlukeneyo zebhayoloji. Izibonelelo zayo ezinokuthi zikhuthaze impilo kunye nokuphila ixesha elide zifundwe ngokubanzi kwiminyaka yamuva.

Kwinqanaba le-molecular, i-NMN i-ribonucleic acid, iyunithi yesakhiwo esisisiseko se-nucleus. Kuye kwaboniswa ukuba kusebenze i-enzyme sirtuin, edlala indima ephambili kwi-metabolism yeselula kunye nokulawulwa kwamandla. Le enzyme iye yadibaniswa neendlela zokulwa nokuguga, njengoko inceda ukulungisa umonakalo kwi-DNA kunye nezinye iinxalenye zeselula ezenzeka ngokwemvelo ngokuhamba kwexesha.

Ukongeza kwindima yayo kwimveliso yamandla eselula, i-NMN sisithako kwizinto zokuthambisa. Iimpawu zayo ezichasayo zenza ukuba ibe yinto eyaziwayo kwiimveliso zokunakekelwa kwesikhumba ukuthomalalisa kunye nokulungisa ulusu olonakeleyo. Ikwasetyenziswa ngokuqhelekileyo kwiimveliso zokunakekelwa kweenwele ukunceda ukuqinisa iinwele kunye nokunciphisa ukuphuka.

I-NMN ikholisa ukubonakala njengomgubo omhlophe ukuya kumthubi wekristale ongenavumba libonakalayo. Gcina kwindawo eyomileyo kwiqondo lokushisa kunye kude nokukhanya, kunye neshelufu yeenyanga ezingama-24. Xa ithathwa njengesongezelelo.

Uphando malunga neenzuzo ezinokuthi zenzeke ze-NMN zisaqhuba, kodwa iziphumo zangaphambili zibonisa ukuba ingaba sisixhobo esisebenzayo sokunciphisa ukuhla okunxulumene neminyaka ekusebenzeni kwamaselula kunye nokukhuthaza impilo yonke. Njengesiqhelo, kubalulekile ukudibana nomboneleli wezempilo ukufumanisa ukuba i-NMN ikulungele na. Ngeenzuzo zayo zempilo ezinokuthi zibekho kunye nesehlo sendalo kuzo zonke iintlobo zobomi, i-NMN yi-molecule eqinisekileyo ukuba iqhubekile ukutsala ingqalelo yabaphandi kunye nabasebenzisi ngokufanayo.

Ukusetyenziswa kwe-β-nicotinamide mononucleotide kubandakanya:

Ukuchasana nokuguga: I-β-nicotinamide mononucleotide iyaziwa ngokuvula i-sirtuins, eziyi-enzymes ezidlala indima ebalulekileyo ekulawuleni ukuguga kwamaselula. Ifundwe ngamandla ayo ekukhuthazeni ukulungiswa kweselula, ukuphucula umsebenzi we-mitochondrial, kunye nokuphucula ubomi obude.

I-energy metabolism: I-β-nicotinamide mononucleotide isandulela se-nicotinamide adenine dinucleotide (NAD +), i-coenzyme ebandakanyeka kwiinkqubo ezahlukeneyo ze-metabolic. Ngokunyusa amanqanaba e-NAD +, i-β-nicotinamide mononucleotide inokuxhasa ukuveliswa kwamandla kunye nemetabolism.

I-Neuroprotection: Uphononongo lubonisa ukuba i-β-nicotinamide mononucleotide inokuba nemiphumo ye-neuroprotective ngokuphucula imisebenzi yeselula kunye nokukhusela kuxinzelelo lwe-oxidative kunye nokuvutha. Ibonise amandla ekunyangeni izifo ze-neurodeergenerative ezinxulumene nobudala ezifana ne-Alzheimer kunye ne-Parkinson.

Impilo ye-cardiovascular: I-β-nicotinamide mononucleotide iphandwe ngamandla ayo ekuphuculeni impilo ye-cardiovascular. Inokukunceda ukukhusela uxinzelelo lwe-oxidative, ukuvuvukala, kunye nomonakalo we-vascular, ngaloo ndlela unciphisa umngcipheko wezifo zenhliziyo.

Umthambo wokusebenza: Ezinye izifundo zibonisa ukuba i-β-nicotinamide mononucleotide inokuphucula ukusebenza komthambo kunye nokunyamezela ngokuphucula umsebenzi we-mitochondrial kunye nokuveliswa kwamandla.