Ukulungiswa kunye noKhuseleko lweZithako zokuKhathalela ulusu: iCeramide

I-Ceramide luhlobo lwee-amide compounds ezenziwe ngokuchithwa kwamanzi e-long-chain fatty acids kunye neqela le-amino le-sphingomyelin, ngokukodwa i-ceramide phosphorylcholine kunye ne-ceramide phosphatidylethanolamine, i-phospholipids zizinto eziphambili ze-membrane zeseli, kunye ne-40% -50% ye-sebum. i-stratum corneum iqukethe i-ceramide, eyona nxalenye iphambili ye-matrix ye-inter-cellular, kwaye idlala indima ebalulekileyo ekugcineni ibhalansi yamanzi ye-stratum corneum. I-Ceramide inamandla amakhulu okubopha iimolekyuli zamanzi, kwaye igcina ukufuma kwesikhumba ngokwenza i-mesh structure kwi-stratum corneum. Ngoko ke, i-ceramide inamandla okugcina ukufuma kwesikhumba.

I-Ceramides (Cers) ikhona kuzo zonke iiseli ze-eukaryotic kwaye idlala indima ebalulekileyo ekulawuleni ukuhlukana kweeseli, ukwanda, i-apoptosis, ukuguga kunye neminye imisebenzi yobomi. Njengenxalenye ephambili ye-intercellular lipids kwi-stratum corneum yesikhumba, i-ceramide ayisebenzi nje njenge-molecule yesithunywa sesibini kwindlela ye-sphingomyelin, kodwa idlala indima ebalulekileyo kwinkqubo yokwakheka kwe-epidermal stratum corneum, enomsebenzi wokugcina. isithintelo solusu, ukufumisa, ukuchasa ukuguga, ukuba mhlophe, kunye nonyango lwezifo.

Nanga amanye amanqaku aphambili malunga neekeramidi:

Indima yoLwakhiwo

I-ceramide yinxalenye enkulu ye-lipid bilayers kwi-membrane yeseli, kwaye ininzi kakhulu kwindawo engaphandle yesikhumba. Kwi-stratum corneum, i-ceramide inceda ukwenza umqobo okhuselayo okhusela ukulahlekelwa kwamanzi kunye nokukhusela ulusu kwizinto ezicasulayo zangaphandle.

Skin Barrier Function

I-stratum corneum isebenza njengesithintelo kwindalo yangaphandle, kwaye ukubunjwa kwee-ceramides kolu luhlu kubalulekile ekugcineni ukukhutshwa kwesikhumba kunye nokuthintela ukungena kwezinto ezinobungozi. Ukunqongophala kwee-ceramide kunokukhokelela eluswini olomileyo kunye nokungasebenzi kakuhle komqobo.

Ukuguga kunye neeMeko zolusu

Amanqanaba eeceramide eluswini athanda ukuncipha ngokuya ngeminyaka, kwaye oku kuncipha kuhambelana neemeko ezifana nesikhumba esomileyo kunye nemibimbi. Kwezinye iimeko zesikhumba, ezifana ne-eczema, i-psoriasis, kunye ne-atopic dermatitis, kunokubakho ukuphazamiseka ekubunjweni kwe-ceramide, okunegalelo kwi-pathology yezi meko.

Izicelo zokuthambisa kunye neDermatological

Ngenxa yendima yabo kwimpilo yolusu, iiceramide zihlala zibandakanyiwe kwiimveliso zokhathalelo lwesikhumba. Ukusetyenziswa kwe-ceramide kwimixholo kunokunceda ukubuyisela kunye nokugcina umqobo wolusu, okunokuba luncedo kubantu abanolusu olomileyo okanye olubuthathaka.

Iintlobo zeeCeramides

Kukho iintlobo ezininzi zeekeramidi (ezikhethwe ngamanani afana neCeramide 1, iCeramide 2, njl.), kwaye uhlobo ngalunye lunolwakhiwo olwahluke kancinane. Ezi ntlobo zahlukeneyo ze-ceramide zinokuba nemisebenzi ethile eluswini.

Imithombo yokutya

Nangona i-ceramide iveliswa ngokuyinhloko emzimbeni, uphando oluthile lubonisa ukuba izinto ezithile zokutya, ezifana ne-sphingolipids ezifunyenwe kukutya okuthile njengamaqanda, zinokufaka isandla kumanqanaba e-ceramide.