Yintoni iFisetin?

Fisetinyi-flavonoid eyenzeka ngokwemvelo efumaneka kwiintlobo ngeentlobo zeziqhamo kunye nemifuno, kubandakanywa amaqunube, ii-apile, iidiliya, iitswele, kunye namakhukhamba. Ilungu losapho lwe-flavonoid, i-fisetin yaziwa ngombala wayo otyheli oqaqambileyo kwaye iye yamkelwa ngenxa yeenzuzo zayo zempilo.

I-Fisetin yi-flavonoid ye-subclass ye-flavonol. Yikhompawundi ye-polyphenolic enegalelo kumbala kunye nencasa yezityalo ezininzi.Fisetinayisosithako sokutya kuphela kodwa ikwangumxube we-bioactive oye watsala ingqalelo yezenzululwazi ngezinto ezinokubakho zonyango.

Fisetinikakhulu ifumaneka kwiziqhamo ezahlukeneyo kunye nemifuno. Eyona mithombo ityebileyo ibandakanya:

• Amaqunube: Amaqunube aqulathe eyona nto iphezulu yefisetin, nto leyo ebenza babe lukhetho olumnandi nolunempilo.
• Ama-apile: Ii-apile ngomnye umthombo obalaseleyo wale flavonoid, ngakumbi ixolo.
• Iidiliya: Zombini iidiliya ezibomvu neziluhlaza zinefisetin, ezinceda zisebenze njenge-antioxidant.
• Itswele: Itswele, ngakumbi elibomvu, liyaziwa ngokuba nobutyebi beflavonoids, kubandakanya nefisetin.
• Ikhukhamba: Le mifuno ihlaziyayo nayo iqulethe i-fisetin, eyandisa izibonelelo zayo zempilo.

Yongeza oku kutya kwisidlo sakho kunokunceda ukwandisa kwakhoi-fisetinukuthatha kunye nokukhuthaza impilo yonke.

I-Fisetin yi-antioxidant enamandla, nto leyo ethetha ukuba inceda ukunciphisa ii-radicals zamahhala emzimbeni. I-radicals yamahhala i-molecule engazinzanga enokubangela uxinzelelo lwe-oxidative, ekhokelela kumonakalo weseli kunye negalelo kwiintlobo zezifo ezingapheliyo, kuquka umhlaza kunye nesifo senhliziyo. Ngokunciphisa uxinzelelo lwe-oxidative,i-fisetininokunceda ukukhusela iiseli kunye nokukhuthaza impilo yonke.

I-Fisetin ineempawu ezichasayo kwaye inokunceda ukunciphisa ukuvuvukala emzimbeni. Esi siphumo sinokuba luncedo ngakumbi kubantu abanezifo ezivuthayo.

I-Fisetin ifumene ingqwalasela eninzi kwimiphumo yayo ye-neuroprotective. Uphando lucebisa ukuba i-fisetin inokunceda ukukhusela iiseli zengqondo kumonakalo kunye nokuxhasa umsebenzi wokuqonda. Uphononongo lubonise ukuba i-fisetin inokuphucula inkumbulo kunye nokufunda ngokukhuthaza ukusinda kwe-neuronal kunye nokunciphisa i-neuroinflammation. Oku kwenzai-fisetinikhompawundi edumileyo yokunyanga ukuhla kwengqondo ezinxulumene neminyaka kunye nezifo ze-neurodeergenerative ezifana ne-Alzheimer's.

Uphononongo lubonise ukuba i-fisetin inokuthintela ukukhula kweeseli ezahlukeneyo zomhlaza, kubandakanya ibele, ikholoni kunye neeseli zomhlaza wedlala lobudoda. Kubonakala ngathi ibangela i-apoptosis (ukufa kweseli ecwangcisiweyo) kwiiseli zomhlaza ngelixa ikhusela iiseli ezisempilweni. Ngelixa uphando oluninzi lufuneka, ezi ziphumo ziqaqambisa amandla e-fisetin njengendlela eyongezelelweyo yonyango lomhlaza.

Fisetininokukhuthaza impilo yentliziyo ngokuphucula umsebenzi we-endothelial kunye nokunciphisa uxinzelelo lwegazi. I-antioxidant kunye ne-anti-inflammatory properties inceda ukukhusela inkqubo ye-cardiovascular system kumonakalo, ngaloo ndlela inciphisa ingozi yesifo senhliziyo.

Uncedo lwezempilo lwefisetin lunokubalelwa kwiindlela ezininzi zokwenza:

• Umsebenzi we-Antioxidant: I-Fisetin inokukhupha i-radicals yamahhala, iphucule inkqubo yokukhusela i-antioxidant yomzimba, kunye nokunciphisa uxinzelelo lwe-oxidative.
• Ukumodareyithwa kweendlela zokubonisa: I-Fisetin ichaphazela iindlela ezahlukeneyo zokubonisa iiselula, kubandakanywa nezo zibandakanyeka ekudumbeni, ukusinda kweeseli, kunye ne-apoptosis.
• I-Gene expression: I-Quercetin inokulawula ukubonakaliswa kwemfuza ehambelana nokudumba, ukulawulwa komjikelo weseli kunye ne-apoptosis, ngaloo ndlela isebenzise iziphumo zayo zonyango.

Ngenxa yeenzuzo zayo ezahlukeneyo zempilo,i-fisetiniphononongwa kwizicelo ezahlukeneyo kunyango kunye nokhathalelo lwempilo. Ezinye iindawo ezinokuthi zifake izicelo ziquka:

• IZONDLO: Izongezo zeFisetin ziya zithandwa kakhulu njengendlela yendalo yokuxhasa impilo kunye nokuphila kakuhle.
• Impilo yengqondo: I-Fisetin inokuphuhliswa ibe yincediso eyenzelwe ukuphucula imemori kunye nomsebenzi wokuqonda, ngakumbi kubantu abalupheleyo.
• Unyango loMhlaza: Abaphandi bafunda amandla e-fisetin njengonyango olongezelelweyo kunyango lomhlaza, ngakumbi amandla ayo okujolisa ngokukhetha iiseli zomhlaza.