Imbali ye-vitamin B1
I-Vitamin B1 lichiza lakudala, i-vitamin B yokuqala ukufunyanwa.
Kwi-1630, i-physicist yaseNetherlands uJacobs · Bonites waqala wachaza i-beriberi eJava (qaphela: kungekhona i-beriberi).
Kwiminyaka ye-80 yenkulungwane ye-19, eyona nto ibangela i-beriberi yafunyanwa okokuqala nguMkhosi waseJapan.
Ngo-1886, uGqr. Christian · Ekmann, igosa lezonyango laseNetherlands, wenza uphononongo malunga netyhefu okanye unxulumano lwe-microbial ye-beriberi kwaye wafumanisa ukuba iinkuku ezitya irayisi epholishiweyo okanye emhlophe zinokubangela i-neuritis, kwaye ukutya irayisi ebomvu okanye amakhoba erayisi kunokuthintela okanye nyanga isifo.
Ngo-1911, uGqr. Casimir Funk, usokhemisti eLondon, wakrola i-thiamine kwibran yerayisi waza wayibiza ngokuba “yivithamin B1”.
Kwi-1936, uWilliam kunye noCline11 bapapasha ukulungiswa kokuqala okuchanekileyo kunye nokuhlanganiswa kwe-vitamin B1.
Imisebenzi ye-biochemical ye-vitamin B1
I-Vitamin B1 yi-vitamin e-soluble yamanzi engenakwenziwa ngumzimba kwaye kufuneka ithathwe ngokutya okanye ukongezwa.
Kukho iintlobo ezintathu ze-vitamin B1 emzimbeni womntu, i-thiamine monophosphate, i-thiamine pyrophosphate (TPP) kunye ne-thiamine triphosphate, apho i-TPP iyindlela ephambili ekhoyo emzimbeni.
I-TPP yi-cofactor yee-enzymes ezininzi ezibandakanyekayo kwi-metabolism yamandla, kuquka i-mitochondrial pyruvate dehydrogenase, i-α-ketoglutarate dehydrogenase complex, kunye ne-cytosolic transketolase, zonke ezibandakanyekayo kwi-carbohydrate catabolism, kwaye zonke ezibonisa umsebenzi oncitshisiweyo ngexesha lokunqongophala kwe-thiamine.
I-Thiamine idlala indima ebaluleke kakhulu kwi-metabolism yomzimba, kwaye ukunqongophala kwe-thiamine kuya kubangela ukuhla kwemveliso ye-adenosine triphosphate (ATP), okubangela ukunqongophala kwamandla eselula; Iyakwazi ukuzisa ukuqokelelwa kwe-lactate, ukuveliswa kwe-radical yamahhala, i-neuroexcitotoxicity, inhibition ye-myelin glucose metabolism kunye nokuveliswa kwe-branched-chain amino acids, kwaye ekugqibeleni ikhokelele kwi-apoptosis.
Iimpawu zokuqala zokunqongophala kwe-vitamin B1
Ukusilela kwe-Thiamine ngenxa yokutya okungalunganga, i-malabsorption, okanye i-metabolism engaqhelekanga kwinqanaba lokuqala okanye lokuqala.
Kwinqanaba lesibini, isigaba se-biochemical, umsebenzi we-transketolases uyancipha kakhulu.
Inqanaba lesithathu, inqanaba le-physiological, libonisa iimpawu eziqhelekileyo ezifana nokuncipha kokutya, ukuphuthelwa, ukucaphuka, kunye ne-malaise.
Kwinqanaba lesine, okanye isigaba seklinikhi, uluhlu lweempawu eziqhelekileyo zokunqongophala kwe-thiamine (beriberi) zivela, kubandakanywa i-claudication engapheliyo, i-polyneuritis, i-bradycardia, i-peripheral edema, i-cardiac enlargement, kunye ne-ophthalmoplegia.
Inqanaba lesihlanu, inqanaba le-anatomical, linokubona utshintsho lwe-histopathological ngenxa yomonakalo kwizakhiwo zeselula, ezinje nge-cardiac hypertrophy, i-cerebellar granule layer degeneration, kunye nokudumba kwe-cerebral microglial.
Abantu abafuna ukuxhaswa kwe-vitamin B1
Abadlali bexesha elide bexesha elide bafuna i-vitamin B1 ukuthatha inxaxheba kwinkcitho yamandla, kwaye i-vitamin B1 isetyenziswe ngexesha lokuzilolonga.
Abantu abatshayayo, abaselayo, nabahlala kude kube sebusuku ixesha elide.
Izigulane ezinezifo ezingapheliyo, ngakumbi izigulane ezine-cardiovascular disease, isifo seswekile, isifo sezintso, isifo se-pulmonary obstructive pulmonary, kunye nezifo eziphindaphindiweyo zokuphefumula.
Kwizigulane ezinoxinzelelo lwegazi oluphezulu, inani elikhulu levithamini B1 lilahlekile kumchamo ngenxa yokuba i-diuretics isetyenziswa ngokuqhelekileyo kwizigulane ezinegazi eliphezulu. Ukongeza, i-digoxin isenokunciphisa amandla eeseli zezihlunu zentliziyo ukufunxa nokusebenzisa ivithamin B1.
Izilumkiso zokusetyenziswa kwe-vitamin B1
1. Xa isetyenziswe kwiidosi ezinkulu, ukuzimisela kwe-serum ye-theophylline yoxinaniso kunokuphazamiseka, ukuzimisela koxinzelelo lwe-uric acid kunokunyuswa ngobuxoki, kwaye i-urobilinogen ingaba yinto ephosakeleyo.
2. I-Vitamin B1 kufuneka isetyenziswe ngaphambi kokutofa kwe-glucose kunyango lwe-Wernicke's encephalopathy.
3. I-Vitamin B1 inokugqithiswa ngokubanzi kukutya okuqhelekileyo, kwaye ukusilela kwe-monovitamin B1 kunqabile. Ukuba iimpawu zinqongophele, i-vitamin B-complex ikhethwayo.
4. Kufuneka kuthathwe ngokwedosi ecetyiswayo, musa ukugqithisa.
5. Dibana nogqirha okanye usokhemesti wabantwana.
6 . Abasetyhini abakhulelweyo nabancancisayo kufuneka basebenzise phantsi kolawulo logqirha.
7. Kwimeko yokusetyenziswa ngokugqithiseleyo okanye iziphumo ezibi kakhulu, funa unyango ngokukhawuleza.
8. Abo bachasene nale mveliso banqatshelwe, kwaye abo bane-allergies kufuneka basebenzise ngokuqaphela.
9. Akuvumelekanga ukusebenzisa le mveliso xa iimpawu zayo zitshintsha.
10. Gcina kwindawo ekude nabantwana.
11. Abantwana kufuneka bajongwe ngumntu omdala.
12. Ukuba usebenzisa amanye amayeza, nceda udibane nodokotela wakho okanye ukhemisti ngaphambi kokusebenzisa le mveliso.
Ixesha lokuposa: Aug-09-2024
