Kusukela ekusungulweni kwemikhiqizo ye-NMN, iye yaduma egameni elithi "elixir of immortal" kanye "nemithi yokuphila isikhathi eside", futhi amasheya omqondo we-NMN ahlobene nawo afunwa yimakethe. U-Li Ka-shing wayethathe i-NMN isikhathi esithile, wabe esesebenzisa izigidi ezingu-200 zamadola e-Hong Kong ekuthuthukisweni kwe-NMN, futhi inkampani kaWarren Buffett nayo yafinyelela ekusebenzisaneni kwamasu nabakhiqizi be-NMN. Ingabe i-NMN, ethandwa izicebi eziphezulu, ingaba nomthelela wokuphila isikhathi eside?
I-NMN i-nicotinamide mononucleotide (Nicotinamide mononucleotide), igama eligcwele lithi “β-nicotinamide mononucleotide”, esesigabeni sokuphuma kwe-vitamin B futhi eyisandulela se-NAD+, engaguqulelwa ku-NAD+ ngokwenza uchungechunge lwama-enzyme. emzimbeni, ngakho-ke ukwesekwa kwe-NMN kuthathwa njengendlela ephumelelayo yokuthuthukisa amazinga e-NAD+. I-NAD+ iwukhiye we-intracellular coenzyme ebandakanyeka ngqo kumakhulukhulu wokusabela kwe-metabolic, ikakhulukazi lezo ezihlobene nokukhiqizwa kwamandla. Njengoba sikhula, amazinga e-NAD+ emzimbeni ehla kancane kancane. Ukuncipha kwe-NAD+ kuzokhinyabeza amandla amaseli okukhiqiza amandla, futhi umzimba uzoba nezimpawu eziwohlokayo njengokuwohloka kwemisipha, ukulahlekelwa ubuchopho, umbala webala, ukuqothuka kwezinwele, njll., okuvame ukubizwa ngokuthi “ukuguga”.
Ngemuva kweminyaka ephakathi, izinga le-NAD + emzimbeni wethu lehla ngaphansi kwe-50% yezinga elincane, yingakho ngemva kweminyaka ethile, kunzima ukubuyela esimweni sobusha kungakhathaliseki ukuthi uphumule kangakanani. Amazinga aphansi e-NAD+ futhi angaholela ezifweni eziningi ezihlobene nokuguga, okuhlanganisa i-atherosclerosis, isifo samathambo, umfutho wegazi ophakeme, isifo senhliziyo nemithambo yegazi, ukuncipha kwengqondo, izifo ze-neurodeergenerative, isifo sikashukela, nomdlavuza, phakathi kokunye.
Ngo-2020, ucwaningo lomphakathi wesayensi nge-NMN empeleni lwalusewusana, futhi cishe zonke izivivinyo zazisekelwe ocwaningweni lwezilwane negundane, futhi okuwukuphela kwesivivinyo somtholampilo sabantu ngo-2020 ngaleso sikhathi saqinisekisa kuphela "ukuphepha" kwezithako zomlomo ze-NMN, futhi ayizange iqinisekise ukuthi izinga le-NAD+ emzimbeni womuntu lenyuka ngemva kokuthatha i-NMN, ingasaphathwa eyokuthi ingabambezela ukuguga.
Manje, eminyakeni emine kamuva, kukhona intuthuko yocwaningo olusha ku-NMN.
Ocwaningweni lomtholampilo lwezinsuku ezingama-60 olwashicilelwa ngo-2022 emadodeni anempilo ephakathi angama-80, izifundo ezithatha u-600-900mg we-NMN ngosuku kwaqinisekiswa ukuthi ziyasebenza ekwandiseni amazinga e-NAD+ egazini, futhi uma kuqhathaniswa neqembu le-placebo, izifundo ukuthatha i-NMN ngomlomo kukhuphule ibanga labo lokuhamba lemizuzu engu-6, futhi ukuthatha i-NMN amaviki angu-12 alandelanayo kungase kuthuthukise izinga lokulala, kuthuthukise ukusebenza komzimba, futhi kuthuthukise amandla omzimba, njengokuthi ukuqinisa amandla okubambelela, ukuthuthukisa isivinini sokuhamba, njll. Yehlisa ukukhathala nokozela, yandisa amandla, njll.
I-Japan kwakuyizwe lokuqala ukwenza izivivinyo zomtholampilo ze-NMN, futhi i-Keio University School of Medicine yaqala ukuhlolwa komtholampilo kwesigaba II ngo-2017 ngemva kokuphothula ukuhlolwa komtholampilo kwesigaba I ukuze kuqinisekiswe ukuphepha. Ucwaningo lwesilingo somtholampilo lwenziwa yi-Shinsei Pharmaceutical, Japan kanye ne-Graduate School of Biomedical Sciences and Health, eNyuvesi yase-Hiroshima. Ucwaningo, olwaqala ngo-2017 unyaka nesigamu, luhlose ukutadisha imiphumela yezempilo yokusetshenziswa kwe-NMN yesikhathi eside.
Ngokokuqala ngqa emhlabeni, kuye kwaqinisekiswa ngokomtholampilo ukuthi ukubonakaliswa kwamaprotheni okuphila isikhathi eside kuyanda ngemva kokuphathwa komlomo kwe-NMN kubantu, futhi ukuvezwa kwezinhlobo ezihlukahlukene zamahomoni kuyanda.
Isibonelo, ingelashwa ukuze kuthuthukiswe izifunda ze-nerve conduction (i-neuralgia, njll.), ukuthuthukiswa kokuzivikela komzimba, ukuthuthukiswa kokungazali kwabesilisa nabesifazane, ukuqinisa imisipha namathambo, ukuthuthukiswa kwebhalansi ye-hormonal (ukuthuthukiswa kokusebenza kwengqondo). isikhumba), ukwanda kwe-melatonin (ukuthuthukiswa kokulala), nokuguga kobuchopho okubangelwa i-Alzheimer's, isifo sikaParkinson, i-ischemic encephalopathy nezinye izifo.
Njengamanje kunocwaningo oluningi lokuhlola imiphumela yokulwa nokuguga ye-NMN kumaseli nezicubu ezihlukahlukene. Kodwa umsebenzi omningi wenziwa ku-vitro noma kumamodeli ezilwane. Kodwa-ke, kunemibiko embalwa yomphakathi mayelana nokuphepha kwesikhathi eside nokusebenza komtholampilo okulwa nokuguga kwe-NMN kubantu. Njengoba kungabonwa ekubuyekezweni okungenhla, inani elincane kakhulu lezifundo zangaphambi komtholampilo kanye nezomtholampilo eziphenye ukuphepha kokuphathwa kwesikhathi eside kwe-NMN.
Kodwa-ke, sekuvele kunezithako eziningi ze-NMN zokulwa nokuguga emakethe, futhi abakhiqizi bamaketha ngenkuthalo le mikhiqizo besebenzisa i-in vitro kanye nemiphumela ye-vivo ezincwadini. Ngakho-ke, umsebenzi wokuqala kufanele kube ukusungula iphrofayili ye-toxicology, i-pharmacology, kanye nokuphepha kwe-NMN kubantu, kuhlanganise neziguli ezinempilo nezifo.
Sekukonke, iningi lezimpawu nezifo zokuncipha kokusebenza okubangelwa "ukuguga" kunemiphumela ethembisayo.
Isikhathi sokuthumela: May-21-2024
