Hlola ukuphepha kwe-Methyl 4-hydroxybenzoate Methylparaben emikhiqizweni yokunakekelwa komuntu siqu

I-Methyl 4-hydroxybenzoate I-Methylparaben enye yama-parabens, iyisilondolozi esinefomula yamakhemikhali i-CH3(C6H4(OH)COO). Kuyi-methyl ester ye-p-hydroxybenzoic acid.
I-Methyl 4-hydroxybenzoate I-Methylparaben isebenza njenge-pheromone yezinhlobonhlobo zezinambuzane futhi iyingxenye ye-queen mandibular pheromone.
Kuyi-pheromone ezimpisini ezikhiqizwa ngesikhathi se-estrus ezihambisana nokuziphatha kwezimpisi zesilisa ze-alpha ezivimbela amanye abesilisa ekukhwezeni abesifazane ekushiseni.
I-Methyl 4-hydroxybenzoate I-Methylparaben iyi-ejenti elwa nesikhunta evamise ukusetshenziswa ezinhlobonhlobo zezimonyo nemikhiqizo yokunakekela umuntu. Ibuye isetshenziswe njengesivikelo sokudla.
I-Methyl 4-hydroxybenzoate I-Methylparaben ivamise ukusetshenziswa njengesibulala-sikhunta emithonjeni yokudla ye-Drosophila ku-0.1%. Ku-Drosophila, i-methyl 4-hydroxybenzoate methylparaben inobuthi ekugxilweni okuphezulu, inomphumela we-estrogenic (ukulingisa i-estrogen kumagundane nokuba nomsebenzi ophikisana ne-androgenic), futhi yehlisa izinga lokukhula ezigabeni zesibungu kanye ne-pupal ku-0.2%.
Kunokungqubuzana mayelana nokuthi i-methyl 4-hydroxybenzoate methylparaben noma i-propylparabens iyingozi yini ekugxilweni okuvame ukusetshenziswa ekunakekelweni komzimba noma kuzimonyo. I-Methylparaben kanye ne-propylparaben kubhekwa njengokujwayelekile njengephephile (GRAS) yi-USFDA ngokulondolozwa kokudla kanye nezimonyo zokulwa namagciwane. I-Methyl 4-hydroxybenzoate I-Methylparaben igaywa kalula ngamabhaktheriya avamile enhlabathini, okwenza ingaboli ngokuphelele.
I-Methyl 4-hydroxybenzoate I-Methylparaben imuncwa kalula emgudwini wamathumbu noma ngesikhumba. I-hydrolyzed ibe yi-p-hydroxybenzoic acid futhi ikhishwe ngokushesha emchameni ngaphandle kokunqwabelana emzimbeni. Ucwaningo lwe-acute toxicity lubonise ukuthi i-methylparaben cishe ayinabo ubuthi kokubili komlomo nokuphathwa kwabazali ezilwaneni. Emphakathini onesikhumba esivamile, i-methylparaben cishe ayicasuli futhi ayizwakali; kodwa-ke, kuye kwabikwa ukungezwani komzimba kuma-parabens agayiwe. Ucwaningo olwenziwa ngo-2008 alutholanga ukuncintisana okubophayo kwe-estrogen yomuntu kanye nama-androgen receptors e-methylparaben, kodwa amazinga ahlukene okubophezela okuncintisana abonwe nge-butyl- ne-isobutyl-paraben.
Ucwaningo lubonisa ukuthi i-methylparaben efakwe esikhumbeni ingase isabele nge-UVB, okuholela ekwandeni kokuguga kwesikhumba kanye nokulimala kwe-DNA.
Ukuphendula lokhu kukhathazeka, ezinye izikhungo ezilawulayo nezinhlangano zithathe izinyathelo zokukhawulela ukusetshenziswa kwe-methyl paraben emikhiqizweni ethile. Isibonelo, i-European Union ikhawulela ukugcwala kwe-methyl paraben evunyelwe kuzimonyo, futhi abanye abakhiqizi bakhethe ukwenza kabusha imikhiqizo yabo ukuze ingabi ne-paraben. Ukwengeza, isidingo esikhulayo sezinto ezihlukile zemvelo neziphilayo esikhundleni sokulondolozwa kwendabuko kuye kwaholela ekwakhiweni kokwakheka okusha okungaqukethe i-methyl paraben noma amanye ama-parabens.
I-Methylparaben ithandwa ngokuzinza kwayo nokuhambisana nezinhlobonhlobo zokwakheka. Ngokuvamile ayiwushintshi umbala, iphunga, noma ukuthungwa kwemikhiqizo esetshenzisiwe, iyenze ibe isithako esisebenza ngezindlela eziningi kumkhiqizi. Lokhu kuzinza kunweba impilo yeshalofu futhi kusiza ukugcina ikhwalithi iyonke yomkhiqizo ngokuhamba kwesikhathi.

Abathengi kufanele baqonde ukuzwela kwabo siqu kanye nokungezwani komzimba okungaba khona lapho besebenzisa imikhiqizo equkethe i-methylparaben. Nakuba i-methylparaben ngokuvamile ibhekwa njengephephile ukusetshenziswa ezimonyoni, abanye abantu bangase babe nokucasuka kwesikhumba noma ukungezwani komzimba. Kuhlale kunconywa ukwenza ukuhlolwa kwesichibi ngaphambi kokusebenzisa umkhiqizo omusha ukuthola ukuthi kukhona yini ukusabela okubi okwenzekayo.
Sengiphetha, i-methyl 4-hydroxybenzoate noma i-methylparaben iyisilondolozi esisetshenziswa kakhulu embonini yezimonyo neyokwenza imithi. Nakuba kunempikiswano ngenxa yokukhathazeka mayelana nemiphumela yayo engaba khona emazingeni ama-hormone nempilo yokuzala, isalokhu iyisinqumo esidumile sokulondolozwa komkhiqizo ngenxa yokusebenza kwayo kahle, ukuzinza, nokuhambisana nezinhlobonhlobo zokwakheka. Njengoba isidingo semikhiqizo yemvelo kanye nemvelo sikhula, ukusetshenziswa kwe-methylparaben kungenzeka kuguquke futhi ezinye izilondolozi zingase zivame kakhulu emakethe. Abathengi kufanele baqonde izithako emikhiqizweni abayisebenzisayo futhi benze izinqumo ezihambisana nalokho abakuthandayo kanye nezinto ezibakhathazayo.