Eminyakeni yamuva nje, i-Nicotinamide Mononucleotide (NMN) iye yavela njengenhlanganisela yomhlabathi endaweni yokulwa nokuguga kanye nempilo ye-metabolic. Njengoba ososayensi behlola ubunkimbinkimbi bokuguga kwamaselula kanye ne-metabolism, i-NMN igqama njengenguquko yegeyimu engaba nemithelela ebalulekile yokuphila isikhathi eside kanye nempilo enhle iyonke. Lesi sihloko sihlola ukuthi iyini i-NMN, izinzuzo zayo ezingaba khona, kanye nendima yayo esikhathini esizayo sezempilo nokuphila kahle.
YiniI-Nicotinamide Mononucleotide?
I-Nicotinamide Mononucleotide iyinucleotide eyenzeka ngokwemvelo etholakala ku-nicotinamide, uhlobo lukavithamini B3 (niacin). Idlala indima ebalulekile ekukhiqizweni kwe-Nicotinamide Adenine Dinucleotide (NAD+), i-coenzyme ebalulekile ezinqubweni eziningi zezinto eziphilayo. I-NAD+ ibandakanyeka ekukhiqizweni kwamandla eselula, ukulungiswa kwe-DNA, kanye nokulawulwa kwezindlela ze-metabolic.
Njengoba sikhula, amazinga e-NAD+ ayehla, ahlotshaniswa nezimo ezihlukahlukene ezihlobene nobudala kanye nokuphazamiseka kwe-metabolic. Ukwengezwa kwe-NMN kucatshangwa ukuthi kuzomelana nalokhu kwehla ngokukhuphula amazinga e-NAD+, okungenzeka kunikeze uhla lwezinzuzo zezempilo.
Isayensi EsemuvaNMN
Umsebenzi oyinhloko we-NMN uwukusebenza njengesandulela se-NAD+, okubalulekile ekusebenzeni kahle kwezinqubo zamaselula. I-NAD+ iyingxenye yokukhiqizwa kwamandla ngaphakathi kwe-mitochondria, izindlu zamandla zamaseli. Iphinde ibambe iqhaza ekwenzeni kusebenze ama-sirtuin, iqembu lamaprotheni axhumene nokuphila isikhathi eside kanye nokulawulwa kwe-metabolic.
Ucwaningo selukhombisile ukuthi ukukhuphuka kwamazinga e-NAD+ ngokufakwa kwe-NMN kungaba nomthelela omuhle ezicini ezimbalwa zempilo. Ucwaningo lwezilwane luphakamisa ukuthi i-NMN ingathuthukisa ukusebenza kwe-metabolic, ithuthukise ukukhuthazela ngokomzimba, futhi ikhuthaze impilo engcono yokuqonda. Nakuba izifundo zabantu zisavela, idatha yokuqala iyathembisa.
Izinzuzo ezingaba khona ze-NMN
Imiphumela Yokuguga:Ngokuthuthukisa amazinga e-NAD+, i-NMN ingasiza ukulwa nemiphumela yokuguga. Ucwaningo luveze ukuthi amazinga aphezulu e-NAD+ angasekela izindlela zokulungisa amaselula, athuthukise ukusebenza kwe-mitochondrial, futhi ehlise ingcindezi ye-oxidative, ebalulekile ekugcineni amandla entsha.
Impilo Ye-Metabolic: NMNkuye kwaxhunyaniswa nokusebenza okuthuthukisiwe kwe-metabolic, okuhlanganisa ukulawulwa okungcono kwe-glucose kanye nokuzwela okuthuthukisiwe kwe-insulin. Lokhu kungaba yinzuzo ikakhulukazi kubantu abaphethe ukuphazamiseka kwe-metabolic noma labo abasengozini yokuba nesifo sikashukela sohlobo 2.
Ukusebenza Okuthuthukisiwe Komzimba:Ucwaningo lubonisa ukuthi ukwesekwa kwe-NMN kungase kuthuthukise ukukhuthazela ngokomzimba namandla emisipha. Lokhu kunomthelela kubasubathi kanye nabantu abadala asebekhulile abafuna ukugcina amazinga okusebenza ngokomzimba kanye nokuqina komzimba wonke.
Umsebenzi wokuqonda:Ucwaningo lwangaphambili lubonisa ukuthi i-NMN ingase isekele impilo yobuchopho nokusebenza kwengqondo. Ngokuthuthukisa amazinga e-NAD+, i-NMN ingase ithuthukise inkumbulo, ukufunda, nokusebenza kwengqondo kukonke.
Amathrendi Emakethe Nocwaningo Lwesikhathi esizayo
Intshisekelo ekhulayo ku-NMN iholele ekwenyukeni kokutholakala kwayo njengesengezo sokudla. Njengoba abathengi befuna izindlela ezintsha zokusekela impilo nokuphila isikhathi eside, i-NMN isheshe yathola ukuthandwa. Kodwa-ke, kubalulekile kubasebenzisi abangaba khona ukuthi bahlale benolwazi mayelana nocwaningo lwakamuva futhi baxhumane nochwepheshe bezokunakekelwa kwezempilo ngaphambi kokuqala noma yiluphi uhlobo lomuthi olusha lokwengeza.
Ucwaningo lwesikhathi esizayo luzobaluleka ekuqinisekiseni izinzuzo zesikhathi eside nokuphepha kwe-NMN. Izivivinyo zemitholampilo ziyaqhubeka ukuze kuqondwe kangcono imiphumela yayo empilweni yabantu kanye nendima yayo engaba khona ekuvimbeleni izifo ezihlobene nobudala. Njengoba umphakathi wesayensi uqhubeka nokuphenya, i-NMN ingaba yisisekelo ekuphishekeleni ukuguga okunempilo nempilo ye-metabolic.
Isiphetho
I-Nicotinamide Mononucleotideimele intuthuko ebalulekile emkhakheni wezempilo nokuphila kahle, enikeza izinzuzo ezingaba khona kusukela emiphumeleni yokulwa nokuguga kuya ekusebenzeni okuthuthukisiwe kwe-metabolic. Njengoba ucwaningo luqhubeka, i-NMN ingase ibe umdlali obalulekile emizamweni yethu yokuthuthukisa ikhwalithi yokuphila nokuphila isikhathi eside. Okwamanje, isithembiso salo sigcizelela ukubaluleka kokuqhubeka nokuhlola nokuqonda emzamweni wempilo engcono kanye nokuphila kahle.
Ulwazi lokuxhumana:
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Isikhathi sokuthumela: Sep-12-2024