I-NMN – C11H15N2O8P i-molecule ekhona ngokwemvelo kuzo zonke izinhlobo zokuphila.

I-NMN (igama eligcwele i-β-nicotinamide mononucleotide) – “C11H15N2O8P” i-molecule eyenzeka ngokwemvelo kuzo zonke izinhlobo zokuphila. Le nucleotide ye-bioactive eyenzeka ngokwemvelo iyisici esibalulekile ekukhiqizeni amandla futhi iyadingeka ezinhlobonhlobo zezinqubo zebhayoloji. Izinzuzo zayo ezingaba khona ekukhuthazeni impilo nokuphila isikhathi eside ziye zacwaningwa kabanzi eminyakeni yamuva.

Ezingeni lamangqamuzana, i-NMN i-ribonucleic acid, iyunithi yesakhiwo eyisisekelo ye-nucleus. Kuye kwaboniswa ukuthi kusebenze i-enzyme i-sirtuin, edlala indima ebalulekile kumetabolism yamaselula kanye nokulawulwa kwamandla. Le enzyme iphinde yaxhunyaniswa nezindlela zokulwa nokuguga, njengoba isiza ukulungisa umonakalo ku-DNA nezinye izakhi zamaselula ezenzeka ngokwemvelo ngokuhamba kwesikhathi.

Ngaphezu kwendima yayo ekukhiqizeni amandla eselula, i-NMN iyisithako sezimonyo. Izakhiwo zayo zokulwa nokuvuvukala ziyenza ibe isithako esidumile emikhiqizweni yokunakekelwa kwesikhumba ukupholisa nokulungisa isikhumba esonakele. Ibuye isetshenziswe ngokuvamile emikhiqizweni yokunakekelwa kwezinwele ukusiza ukuqinisa izinwele nokunciphisa ukuphuka.

I-NMN ivamise ukubonakala njengempushana ecwebezelayo emhlophe kuya kokuphuzi engenalo iphunga elibonakalayo. Gcina endaweni eyomile ekamelweni lokushisa futhi kude nokukhanya, neshalofu impilo yezinyanga ezingu-24. Lapho ithathwa njengesengezo.

Ucwaningo ngezinzuzo ezingaba khona ze-NMN lusaqhubeka, kodwa okutholakele kusenesikhathi kusikisela ukuthi kungase kube ithuluzi eliphumelelayo lokunciphisa ukwehla okuhlobene neminyaka ekusebenzeni kwamaselula kanye nokukhuthaza impilo yonke. Njengenjwayelo, kubalulekile ukuthintana nomhlinzeki wezempilo ukuze uthole ukuthi i-NMN ikulungele yini. Ngezinzuzo zayo zezempilo ezingaba khona kanye nokuvela kwemvelo kuzo zonke izinhlobo zokuphila, i-NMN iyi-molecule eqinisekile ukuthi izoqhubeka nokuheha ukunaka kwabacwaningi nabasebenzisi ngokufanayo.

Ukusetshenziswa kwe-β-nicotinamide mononucleotide kuhlanganisa:

I-anti-aging: I-β-nicotinamide mononucleotide yaziwa ngokwenza ama-sirtuin, okungama-enzyme adlala indima ebalulekile ekulawuleni ukuguga kwamaselula. Kuye kwafundelwa amandla ayo ekukhuthazeni ukulungiswa kwamaselula, ukuthuthukisa ukusebenza kwe-mitochondrial, kanye nokuthuthukisa impilo ende yonke.

Imetabolism yamandla: I-β-nicotinamide mononucleotide iyisandulela se-nicotinamide adenine dinucleotide (NAD+), i-coenzyme ehilelekile ezinqubweni ezihlukahlukene ze-metabolic. Ngokwandisa amazinga e-NAD+, i-β-nicotinamide mononucleotide ingase isekele ukukhiqizwa kwamandla kanye ne-metabolism.

I-Neuroprotection: Ucwaningo lubonisa ukuthi i-β-nicotinamide mononucleotide ingase ibe nemiphumela ye-neuroprotective ngokuthuthukisa imisebenzi yamaselula nokuvikela ekucindezelekeni kwe-oxidative nokuvuvukala. Ibonise amandla ekwelapheni izifo ze-neurodegenerative ezihlobene neminyaka njenge-Alzheimer's kanye ne-Parkinson.

Impilo yenhliziyo nemithambo yegazi: I-β-nicotinamide mononucleotide iphenywe ngamandla ayo ekwenzeni ngcono impilo yenhliziyo nemithambo yegazi. Kungasiza ukuvikela ekucindezelekeni kwe-oxidative, ukuvuvukala, nokulimala kwemithambo yegazi, ngaleyo ndlela kunciphise ingozi yezifo zenhliziyo.

Ukusebenza kokuzivocavoca: Ezinye izifundo ziphakamisa ukuthi i-β-nicotinamide mononucleotide ingase ithuthukise ukusebenza kokuzivocavoca nokukhuthazela ngokuthuthukisa ukusebenza kwe-mitochondrial nokukhiqizwa kwamandla.