Izithako Zokunakekelwa Kwesikhumba Ezilungiswayo Nezokuvikela: I-Ceramide

I-Ceramide iwuhlobo lwezinhlanganisela ze-amide ezakhiwe ukuphelelwa amanzi kwamafutha e-long-chain fatty acids kanye neqembu le-amino le-sphingomyelin, ikakhulukazi i-ceramide phosphorylcholine ne-ceramide phosphatidylethanolamine, ama-phospholipids ayizingxenye eziyinhloko zolwelwesi lwamaseli, kanye no-40% -50% we-sebum. i-stratum corneum iqukethe ama-ceramides, okuyiwo ingxenye eyinhloko ye-inter-cellular matrix, futhi idlala indima ebalulekile ekugcineni ibhalansi yamanzi ye-stratum corneum. I-Ceramide inamandla aqinile okubopha ama-molecule amanzi, futhi igcina umswakama wesikhumba ngokwenza isakhiwo semeshi ku-stratum corneum. Ngakho-ke, ama-ceramide anamandla okugcina umswakama wesikhumba.

Ama-Ceramides (Cers) akhona kuwo wonke amangqamuzana e-eukaryotic futhi adlala indima ebalulekile ekulawuleni ukuhlukaniswa kwamaseli, ukwanda, i-apoptosis, ukuguga kanye neminye imisebenzi yokuphila. Njengengxenye eyinhloko ye-lipids ye-intercellular ku-stratum corneum yesikhumba, i-ceramide ayisebenzi nje njenge-molecule yesithunywa sesibili endleleni ye-sphingomyelin, kodwa futhi idlala indima ebalulekile ekubunjweni kwe-epidermal stratum corneum, enomsebenzi wokulondoloza. ukuvimbela isikhumba, ukuthambisa, ukulwa nokuguga, ukumhlophe, nokwelashwa kwezifo.

Nawa amaphuzu abalulekile mayelana nama-ceramides:

Iqhaza Lesakhiwo

Amaceramide ayingxenye enkulu yama-lipid bilayers kulwelwesi lwamaseli, futhi maningi ikakhulukazi ongqimbeni olungaphandle lwesikhumba. Ku-stratum corneum, ama-ceramide asiza ukwakha umgoqo ovikelayo ovimbela ukulahlekelwa kwamanzi futhi uvikele isikhumba ezintweni ezicasulayo zangaphandle.

Skin Barrier Function

I-stratum corneum isebenza njengesithiyo endaweni yangaphandle, futhi ukwakheka kwama-ceramides kulolu ungqimba kubalulekile ekugcineni ukugeleza kwesikhumba nokuvimbela ukungena kwezinto eziyingozi. Ukuntuleka kwama-ceramides kungaholela esikhumbeni esomile kanye nomsebenzi wokuvimbela okhubazekile.

Ukuguga Nezimo Zesikhumba

Amazinga e-ceramides esikhumbeni avame ukwehla ngokukhula, futhi lokhu kuncipha kuhlotshaniswa nezimo ezifana nesikhumba esomile nemibimbi. Kwezinye izimo zesikhumba, njenge-eczema, i-psoriasis, ne-atopic dermatitis, kungase kube nokuphazamiseka ekubunjweni kwe-ceramide, okunomthelela ekuguleni kwalezi zimo.

Izicelo zezimonyo nezesikhumba

Njengoba kunikezwe indima yabo empilweni yesikhumba, ama-ceramide avame ukufakwa emikhiqizweni yokunakekelwa kwesikhumba. Ukufakwa kwe-ceramides ngezihloko kungasiza ukubuyisela nokugcina umgoqo wesikhumba, okungase kuzuzise abantu abanesikhumba esomile noma esisengozini.

Izinhlobo zamaCeramides

Kunezinhlobo eziningana zama-ceramides (eziqokwe izinombolo ezifana ne-Ceramide 1, i-Ceramide 2, njll.), futhi uhlobo ngalunye lunesakhiwo esihluke kancane. Lezi zinhlobo ezahlukene ze-ceramide zingase zibe nemisebenzi ethile esikhumbeni.

Imithombo Yezokudla

Nakuba ama-ceramides ekhiqizwa ngokuyinhloko emzimbeni, ucwaningo oluthile lubonisa ukuthi izingxenye ezithile zokudla, njenge-sphingolipids ezitholakala ekudleni okuthile njengamaqanda, zingase zibe nomthelela emazingeni e-ceramide.