I-Kingpin of Whitening: I-Kojic Acid

I-Tartaric acid, eyaziwa nangokuthi 'i-kojic acid' noma 'i-kojic acid', iwumkhiqizo wokuvutshelwa kwe-microbial otholakala kusoso yesoya, ku-soya bean paste, ukwenziwa kwewayini, futhi ingatholwa emikhiqizweni eminingi evutshiwe evutshelwe i-Aspergillus.

Ososayensi bokuqala bathola ukuthi izandla zabesifazane abasebenza endaweni yotshwala zimhlophe ikakhulukazi. Ngemva kocwaningo lwemikhiqizo yokuvutshelwa, kwatholakala ukuthi akugcini nje ngokuba nendima enhle ekugcineni ubusha be-curvilinear acid. Iphinde ibe mhlophe nomphumela omuhle okhanyayo. Ngisho, ithoni yesikhumba ayikhathazeki. Abaningi be-dermatologists baseYurophu naseMelika basebenzisa i-2 kuya ku-4% ye-kojic acid ukuphatha i-chloasma ezigulini zabo ngemiphumela emihle.

I-Kojic acid ingavimbela umsebenzi we-tyrosinase futhi imise ukukhiqizwa kwe-melanin. I-Kojic acid ekuhlanganiseni kuka-20 μg/ml ingavimbela umsebenzi wama-enzyme amaningi e-tyrosinase ngo-70% -80%. Ezimonyoni, kunconywa ukuthi wengeze i-0.5% -2% ye-tretinoin, engavimbela ukukhiqizwa kwe-melanin futhi ifinyelele umphumela wokuba mhlophe namabala akhanyayo.

Ngaphezu komphumela wayo wokuba mhlophe, i-kojic acid ine-free radical scavenging kanye nezakhiwo ze-antioxidant. Ingasiza isikhumba se-astringent, ikhuthaze ukuhlanganisa amaprotheni futhi iqinise isikhumba. Ayinayo nje into ethile yokulwa namagciwane, kodwa futhi inekhono elithile lokuthambisa futhi ingasetshenziswa ngisho njengesilondolozi sokudla nezimonyo. I-Kkojic acid ingavimbela umsebenzi we-hyaluronidase, ukuze ikwazi nokuvimbela ukungezwani komzimba.

I-Kojic acid, efana ne-VC, ibophezela kuma-ion ethusi futhi yenza i-tyrosinase ingasebenzi.

I-Kojic acid iphinde ivimbele ukukhiqizwa kwe-melanin oxidation intermediates. I-Kojic acid ikhishwa i-dopaquinone emaphakathi, ngaleyo ndlela yehlise i-substrate yokusabela kweketango futhi ivimbele ukuguqulwa kwe-melanin emaphakathi isuka efomini le-dopaquinone iye kwi-melanin yokugcina. Ukugxila okuphansi kuyakwazi ukuzuza imiphumela emihle ngomphumela wako wodlame . Kungenxa yokuthi umphumela wawo uqinile kangangokuthi ungaholela ekubomvu kwesikhumba kanye ne-dermatitis yokuxhumana. Ngakho-ke, yingakho imikhiqizo eminingi emhlophe inezengezo eziphansi.

Izinzuzo ze-kojic acid ukumuncwa okuphezulu kwe-transdermal, inhibition enhle ye-tyrosinase futhi akukho mphumela we-cytotoxic. Ingasetshenziselwa ukwenza mhlophe, ukususa amabala, ukuthuthukisa ithoni yesikhumba, njll.; futhi ingasebenza futhi ukugcina amanzi futhi ikhulise ukunwebeka kwesikhumba.

Uma usebenzisa i-kojic acid, kungcono ukunaka amaphuzu alandelayo.

Okokuqala, i-kojic acid izohluleka ekukhanyeni okukhanyayo noma ezindaweni ezine-asidi eqinile futhi esikhundleni salokho yandise i-melanin.Ngakho-ke, kunconywa ukuthi imikhiqizo ye-kojic acid isetshenziswe kangcono iyodwa ebusuku.

Okwesibili, ukugwema ukusetshenziswa kwe-salicylic acid, izithelo ze-acids, ukuhlushwa okuphezulu kwe-VC nezinye izithako. Kulula kakhulu ukuvuselela isikhumba bese ugingqika futhi ucekele phansi umgoqo ngokuhlanganisa izithako ezinamandla kakhulu ezicasulayo kakhulu.Okwesithathu, udinga ukwenza i-hydration eqinile, qaphela i-sunscreen ukuvimbela ukulwa nomnyama.

Nakuba i-kojic acid iyi-ace embobeni ezweni elimhlophe, idinga ukusetshenziswa ngokucophelela futhi isetshenziswe ngendlela efanele ukuze idlale indima ebalulekile.