Eminyakeni yakamuva,I-L-carnitineithole ukuthambekela ngokushesha njengesengezo kulabo abathanda ukuqina, abafuna ukunciphisa umzimba, kanye nalabo abafuna ukuthuthukisa impilo yenhliziyo. Le nhlanganisela eyenzeka ngokwemvelo, etholakala cishe kuwo wonke amangqamuzana omzimba womuntu, idlala indima ebalulekile ekugayweni kwamafutha. Nakuba isetshenziswe amashumi eminyaka ezilungiselelweni zezokwelapha ukwelapha izimo ezithile, isanda kuba yisisekelo emhlabeni wezempilo nempilo enhle, ngohlaka olukhula njalo locwaningo olusekela izinzuzo zalo ezingaba khona. Lesi sihloko sizohlola isayensi ngemuva kwe-L-carnitine, izinzuzo zayo zezempilo, nokuduma kwayo okusabalele njengesithasiselo sokudla.
YiniI-L-Carnitine?
I-L-carnitine iyinhlanganisela eyenzeka ngokwemvelo ehlanganiswe ngumzimba kusuka kuma-amino acids i-lysine ne-methionine. Idlala indima ebalulekile ekuthuthweni kwama-acids anamafutha ku-mitochondria - "izindlu zamandla" zamangqamuzana ethu - lapho eshiswa khona ukuze athole amandla. Ngaphandle kwe-L-carnitine eyanele, umzimba ubungazabalaza ukusebenzisa amafutha njengomthombo wamandla, okungaholela ekuvinjeni kwe-metabolism nokuqoqwa kwamafutha.
I-L-carnitine ikhiqizwa ngokuyinhloko esibindi nezinso, futhi amazinga ayo aphezulu kakhulu ezicutshini ezithembele emafutheni ukuze uthole amandla, njengemisipha yamathambo nenhliziyo. Ibuye itholakale ekudleni, ikakhulukazi emikhiqizweni yezilwane njengenyama nenhlanzi, yingakho abantu abadla imifino kanye nezilwane bengase babe namazinga aphansi alesi sakhi futhi ngezinye izikhathi bayelulekwa ukuthi bangezelele kuso.
I-L-Carnitinekanye Nokusebenza Kokuzivocavoca
Enye yezindawo eziphoqelela kakhulu zocwaningo ezizungezile i-L-carnitine umthelela wayo ekusebenzeni ngokomzimba, ikakhulukazi imidlalo yokukhuthazela. Inhlanganisela iye yaboniswa ukuthuthukisa ukusebenza kokuzivocavoca ngokwandisa amandla omzimba okusebenzisa amafutha njengomthombo wamafutha, ngaleyo ndlela igcine izitolo ze-glycogen. I-Glycogen iwumthombo wamandla oyinhloko womzimba ngesikhathi sokuzivocavoca okukhulu, futhi ukuyigcina kubalulekile ukuze ugcine amazinga aphezulu okusebenza ngesikhathi sokuzivocavoca isikhathi eside.
Ucwaningo oluningana lubonise ukuthi i-L-carnitine supplementation ingabambezela ukuqala kokukhathala futhi inciphise ukulimala kwemisipha ngemva kokuzivocavoca. Lokhu kunenzuzo ikakhulukazi kubasubathi abahileleke emidlalweni yokubekezela njengokugijima amabanga amade, ukugibela amabhayisikili, nokubhukuda. Ucwaningo olwanyatheliswa kuyi-Journal of Physiology lwathola ukuthi i-L-carnitine supplementation yanciphisa ubuhlungu bemisipha kanye nezikhathi zokuvuselela ezithuthukisiwe ngemva kokuzivocavoca okuphelele, ukusiza abagijimi ukuba baqeqeshe kanzima futhi balulame ngokuphumelelayo.
Ngaphezu kwalokho, i-L-carnitine ingase ibe nomthelela ekulondolozweni kwesisindo somzimba esithambile. Lokhu kubalulekile kubasubathi kanye nabathandi bokuqina, njengoba imisipha yemisipha idlala indima ebalulekile kumetabolism namandla jikelele.
I-L-Carnitine Yezempilo Yenhliziyo
Ngaphezu kokuthandwa kwayo emibuthanweni yokuqina nokuncipha kwesisindo, I-L-carnitinefuthi ithole ukunakwa ngezinzuzo zayo ezingaba khona empilweni yenhliziyo. Njengoba i-L-carnitine isiza ukwenza lula ukusetshenziswa kwama-fatty acids ukuze uthole amandla, idlala indima ebalulekile ekugcineni impilo yenhliziyo, ethembele kakhulu ekusetshenzisweni kwamafutha ukuze kube namandla.
Isixhumanisi PhakathiI-L-Carnitinekanye Nokuncipha Kwesisindo
I-L-carnitine sekuyisikhathi eside idayiswa njengesengezo esishisa amafutha, futhi abantu abaningi bayayisebenzisa ngethemba lokuchitha amakhilogremu angafuneki. Isizathu sokusetshenziswa kwayo ekunciphiseni isisindo silula: ngoba i-L-carnitine isiza ukuthulula ama-fatty acids ku-mitochondria, kukholakala ukuthi ithuthukisa ikhono lomzimba lokushisa amafutha ukuze uthole amandla.
Kodwa-ke, ucwaningo mayelana nokusebenza kwe-L-carnitine ekulahlekelweni kwesisindo luye lwaveza imiphumela exubile. Ezinye izifundo ziphakamisa ukuthi i-L-carnitine supplementation ingakhuphula i-oxidation yamafutha, ikakhulukazi uma ihlangene nokuzivocavoca. Ucwaningo olwanyatheliswa kuyi-American Journal of Clinical Nutrition luthole ukuthi i-L-carnitine supplementation, lapho ihlanganiswa nomsebenzi womzimba, iholele ekushiseni kwamafutha kubantu abakhuluphele.
Ngakolunye uhlangothi, ezinye izivivinyo zibonise umthelela omncane ongekho ekulahlekelweni kwamafutha lapho i-L-carnitine ithathwa ngaphandle kokuzivocavoca noma izinguquko zokudla. Lokhu kuphakamisa ukuthi i-L-carnitine ingase inikeze izinzuzo zokulahlekelwa isisindo kuphela uma isetshenziswa njengengxenye yohlelo olubanzi lokufaneleka, hhayi njengephilisi eliyisimangaliso ngokwayo.
Noma kunjalo, ukuthandwa okukhulayo kweI-L-carnitinenjengesengezo esishisa amafutha sikhuluma ngokukhanga kwayo phakathi kwalabo abazama ukulawula isisindo sabo. Itholakala kabanzi ngezindlela ezihlukahlukene—amaphilisi, izimpushana, uketshezi, ngisho neziphuzo ezinikeza amandla.
Olunye ucwaningo lubonisa ukuthi i-L-carnitine supplementation ingasiza ekuthuthukiseni impilo yenhliziyo ngokunciphisa izici eziyingozi ezifana ne-cholesterol ephezulu nomfutho wegazi ophezulu. Ucwaningo olushicilelwe ku-Molecular Nutrition & Food Research lubonise ukuthi i-L-carnitine inganciphisa amazinga e-cholesterol futhi ithuthukise ukusebenza kwe-endothelial, okubalulekile ekugcineni imithambo yegazi enempilo.
Ukwengeza, i-L-carnitine iye yafundiswa amandla ayo okusiza ekwelapheni izimo ezithile zenhliziyo. Obunye ubufakazi bubonisa ukuthi kungase kube yinzuzo kubantu abanezimo zenhliziyo ezingapheli ezifana nokuhluleka kwenhliziyo eqinile (CHF) noma i-angina, njengoba kungasiza ukuthuthukisa amandla okuzivocavoca nokunciphisa izimpawu. Nokho, ucwaningo olwengeziwe luyadingeka ukuze kusungulwe ngokugcwele indima yalo ekulawuleni isifo senhliziyo.
Ukuphepha kanye Nemiphumela Emibi yeI-L-Carnitine
Kubantu abaningi, i-L-carnitine supplementation ngokuvamile ibhekwa njengephephile uma ithathwa ngezilinganiso ezifanele. Itholakala ezitolo ngezinhlobo ezahlukene, futhi imiphumela engemihle ngokuvamile imnene, okuhlanganisa isicanucanu, ukuphazamiseka kokugaya ukudla, noma iphunga lomzimba "elishisayo".
Kodwa-ke, kunamaqembu athile okufanele aqaphe lapho esebenzisa izithasiselo ze-L-carnitine. Abantu abanesifo sezinso, isibonelo, kufanele bathintane nomhlinzeki wabo wezempilo ngaphambi kokuqala ukwesekwa, njengoba ikhono lomzimba lokucubungula i-L-carnitine lingase libe sengozini kulabo abanokukhubazeka kwezinso. Ukwengeza, kube nokukhathazeka mayelana nokuphepha kwesikhathi eside kwe-high-dose L-carnitine supplements, ikakhulukazi maqondana nempilo yenhliziyo. Ucwaningo oluthile luye lwaphakamisa ukuthi amazinga aphezulu e-L-carnitine angakhuthaza ukwakheka kwe-trimethylamine-N-oxide (TMAO), i-compound ehlotshaniswa nengozi eyengeziwe yesifo senhliziyo. Nakuba ucwaningo olwengeziwe ludingeka kule ndawo, lokhu okutholakele kugcizelela ukubaluleka kokusebenzisa izithasiselo ze-L-carnitine ngokuzibophezela.
Isiphetho: Isengezo Esinezici Eziningi Ngokukhula Kokuduma
I-L-carnitine isibe yisisekelo emhlabeni wezempilo nokuqina, nezinzuzo zayo ezingase zibe khona zokunciphisa umzimba, ukusebenza kokuzivocavoca, nempilo yenhliziyo ethola ukunakwa okubanzi. Nakuba ubufakazi besayensi busathuthuka, abantu abaningi bayaqhubeka nokuphendukela ku-L-carnitine njengengxenye yendlela yabo yokuphila kahle, ikakhulukazi njengengxenye yokuzivocavoca kanye nezinguquko zokudla.
Njenganoma yisiphi isithasiselo, kubalulekile ukuthi abathengi basondeleI-L-carnitinengeso elibukhali, ukuqonda kokubili izinzuzo zayo ezingase zibe khona kanye nemingcele. Labo abacabangela i-L-carnitine supplementation kufanele bakhulume nomhlinzeki wezempilo ukuze baqinisekise ukuthi kufanelekile izidingo zabo ngabanye kanye nemigomo yezempilo.
Njengoba ucwaningo mayelana nokusetshenziswa okubanzi kwe-L-carnitine luqhubeka, kuyacaca ukuthi le nhlanganisela ibambe indawo ebalulekile emakethe yezempilo nempilo enhle-futhi kungenzeka ihlale iyisinqumo esithandwayo kulabo abafuna ukwandisa amandla emizimba yabo ekushiseni. amafutha, athuthukise ukusebenza, futhi asekele impilo yonke yenhliziyo.
Ulwazi lokuxhumana:
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Isikhathi sokuthumela: Nov-21-2024