Isizukulwane sesithathu se-Carnosine Derivatives:N-acetyl carnosine

Emlandweni waseShayina, isidleke senyoni sithathwa njenge-tonic, eyaziwa ngokuthi "i-Oriental Caviar". Kulotshwe ku-Materia Medica ukuthi isidleke senyoni “siyithoni futhi singahlanzwa, futhi siwumuthi ongcwele wokulawula ukuntula nokusebenza”. I-N-Acetyl Neuraminic Acid iyisithako esikhulu esidlekeni senyoni, ngakho-ke yaziwa nangokuthi i-acid yenyoni, futhi okuqukethwe kwayo kuyinkomba yezinga lezinyoni.

I-N-acetyl carnosine (NAC) iyinhlanganisela eyenzeka ngokwemvelo ngokwekhemikhali ehlobene ne-dipeptide carnosine.Isakhiwo samangqamuzana e-NAC siyefana naleso se-carnosine ngaphandle kokuthi sithwala iqembu le-acetyl elengeziwe. I-acetylation yenza i-NAC imelane kakhulu nokucekelwa phansi yi-myostatin, i-enzyme ephula i-myostatin ibe ama-amino acid ayi-β-alanine ne-histidine.

I-O-Acetyl Carnosine iwukuphuma kwe-carnosine okwenzeka ngokwemvelo okwaqala ukukhonjwa kuzicubu zemisipha onogwaja ngo-1975. Kubantu, i-acetyl carnosine itholakala ngokuyinhloko emisipha yamathambo, futhi izicubu zemisipha zikhipha isakhi lapho umuntu ezivocavoca.

Njengesizukulwane sesithathu sokuphuma kwe-carnosine yemvelo, i-acetyl carnosine inamandla aphelele, ukuguqulwa kwe-acetylation kwenza kube mancane amathuba okuba ibonwe futhi ichithwe yi-carnosine peptidase emzimbeni womuntu, futhi inokuqina okuphezulu.Zinemiphumela esobala ku-antioxidant, anti-glycation , ukulwa nokuvuvukala, njll.

I-Acetyl carnosine ayigcini nje ngokuthuthukisa ukuzinza, kodwa futhi izuza imiphumela emihle kakhulu ye-antioxidant ne-anti-inflammatory ye-carnosine.

I-Acetyl carnosine inemiphumela eminingi, hhayi nje kuphela engakwazi ukudlala ukuqina, ukuthambisa, ukuthambisa kanye neminye imiphumela yokunakekelwa kwesikhumba, kodwa futhi ivimbele isizukulwane sama-radicals wamahhala we-oxygen esebenzayo, izici ezivuthayo, isetshenziswe kabanzi ekwelapheni izimpawu ze-cataract zamaconsi iso.

I-Acetyl carnosine nayo ivame ukusetshenziswa kwezinye izimonyo noma imikhiqizo yokunakekelwa.Isibonelo, imikhiqizo yokunakekelwa kwesikhumba ebusweni, umzimba, intamo, izandla, nesikhumba se-periocular; imikhiqizo yobuhle neyokunakekela (isb., amafutha okugcoba, okhilimu be-AM/PM, ama-serum); ama-antioxidant, ama-conditioner esikhumba, noma ama-moisturizers ezimonyoni nakwimikhiqizo ye-skincare; kanye nezithuthukisi zokupholisa emafutheni.

Ukufingqa, njengezinto ezenzeka ngokwemvelo emzimbeni womuntu, i-myostatin kanye nokuphuma kwayo kunezinga eliphakeme kakhulu lokuphepha.