I-Vitamin B1 - I-Cofactors ye-Human Energy Metabolism

I-Vitamin B1, eyaziwa nangokuthi i-thiamine, iyivithamini encibilikayo emanzini edlala indima ebalulekile ekusetshenzisweni kwama-carbohydrate. Nawa amaphuzu abalulekile mayelana ne-vitamin B1:
Isakhiwo Sekhemikhali:
I-Thiamine i-vitamin B encibilika emanzini enesakhiwo samakhemikhali esihlanganisa i-thiazole nendandatho ye-pyrimidine. Itholakala ngezindlela eziningana, kanti i-thiamine pyrophosphate (TPP) iyifomu le-coenzyme esebenzayo.
Umsebenzi:
I-Thiamine ibalulekile ekuguquleni ama-carbohydrate abe amandla. Isebenza njenge-coenzyme emisebenzini eminingana ebalulekile ye-biochemical ehilelekile ekuqhekekeni kweglucose.
Idlala indima ebalulekile ekusebenzeni kwamangqamuzana ezinzwa futhi ibalulekile ekusebenzeni kahle kwesimiso sezinzwa.
Imithombo:
Imithombo emihle yokudla ye-thiamine ihlanganisa okusanhlamvu, okusanhlamvu okuqinisiwe, okusanhlamvu (njengobhontshisi nodali), amantongomane, imbewu, ingulube, nemvubelo.
Ukuntula:
Ukuntuleka kwe-thiamine kungaholela esimweni esaziwa ngokuthi i-beriberi. Kunezinhlobo ezimbili eziyinhloko ze-beriberi:
I-Wet Beriberi:Kubandakanya izimpawu zenhliziyo nemithambo yegazi futhi kungaholela ekuhlulekeni kwenhliziyo.
I-Dry Beriberi:Kuthinta isimiso sezinzwa, okuholela ezimpawini ezinjengobuthakathaka bemisipha, ukushoshozela, nobunzima bokuhamba.
Ukuntuleka kwe-thiamine kungase kwenzeke nakubantu abadla ukudla okunama-carbohydrate acolisisiwe kanye nokudla okunothe nge-thiamine.
Izimo Ezihlotshaniswa Nokuntuleka Kwe-Thiamine:
Ukuphuza ngokweqile kuyimbangela evamile yokuntuleka kwe-thiamine. Lesi simo saziwa nge-Wernicke-Korsakoff syndrome, futhi singaholela ezimpawu ezibucayi zemizwa.
Izimo ezithinta ukumuncwa kwezakhi, njengesifo sika-Crohn noma ukuhlinzwa kwe-bariatric, zingase zandise ingozi yokuntuleka kwe-thiamine.
I-Daily Allowance Enconyiwe (RDA):
Umthamo onconywayo wansuku zonke we-thiamine uyahlukahluka ngeminyaka, ubulili, kanye nesigaba sokuphila. Ivezwa ngama-milligrams.
Ukwengeza:
Ukwengezwa kwe-thiamine kuvame ukutuswa ezimweni zokuntuleka noma lapho kunesidingo esandayo, njengalapho ukhulelwe noma ukuncelisa. Kwesinye isikhathi ibuye imiselwe abantu abanezimo ezithile zezempilo.
Ukuzwela Kokushisa:
I-Thiamine izwela ukushisa. Ukupheka nokucubungula kungaholela ekulahlekelweni kwe-thiamine ekudleni. Ngakho-ke, kubalulekile ukufaka izinhlobonhlobo zokudla okusha futhi okugaywe kancane ekudleni ukuze kuqinisekiswe ukudla okwanele.
Ukusebenzelana Nemithi:
Eminye imithi, njengama-diuretics athile kanye nama-anti-seizure, ingase yandise isidingo somzimba se-thiamine. Kubalulekile ukuthintana nochwepheshe bezempilo uma kukhona ukukhathazeka ngesimo se-thiamine, ikakhulukazi endabeni yokusetshenziswa kwemithi.
Ukuqinisekisa ukudla okwanele kwe-thiamine ngokudla okunomsoco kubalulekile empilweni iyonke, ikakhulukazi ekusebenzeni kahle kwesimiso sezinzwa kanye ne-energy metabolism. Uma kukhona ukukhathazeka mayelana nokuntuleka kwe-thiamine noma ukwesekwa, kuyatuseka ukuthintana nochwepheshe bezokunakekelwa kwezempilo ukuze uthole isiqondiso esiqondene nawe.